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Article: Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption
Title | Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption |
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Authors | |
Keywords | anticancer charge transfer functional coatings and films mitochondria vanadium dioxide |
Issue Date | 2019 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/20566646 |
Citation | Global Challenges, 2019, v. 3 n. 3, p. article no. 1800058 How to Cite? |
Abstract | A biomaterials surface enabling the induction of tumor cell death is particularly desirable for implantable biomedical devices that directly contact tumor tissues. However, this specific antitumor feature is rarely found. Consequently, an antitumor‐cell nanocoating comprised of vanadium dioxide (VO2) prepared by customized reactive magnetron sputtering has been proposed, and its antitumor‐growth capability has been demonstrated using human cholangiocarcinoma cells. The results reveal that the VO2 nanocoating is able to interrupt the mitochondrial electron transport chain and then elevate the intracellular reactive oxygen species levels, leading to the collapse of the mitochondrial membrane potential and the destruction of cell redox homeostasis. Indeed, this chain reaction can effectively trigger oxidative damage in the cholangiocarcinoma cells. Additionally, this study has provided new insights into designing a tumor‐cell‐inhibited biomaterial surface, which is modulated by the mechanism of mitochondria‐targeting tumor cell death. |
Persistent Identifier | http://hdl.handle.net/10722/278239 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 0.901 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LI, J | - |
dc.contributor.author | JIANG, M | - |
dc.contributor.author | ZHOU, H | - |
dc.contributor.author | JIN, P | - |
dc.contributor.author | Cheung, KMC | - |
dc.contributor.author | CHU, PK | - |
dc.contributor.author | Yeung, KWK | - |
dc.date.accessioned | 2019-10-04T08:10:10Z | - |
dc.date.available | 2019-10-04T08:10:10Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Global Challenges, 2019, v. 3 n. 3, p. article no. 1800058 | - |
dc.identifier.issn | 2056-6646 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278239 | - |
dc.description.abstract | A biomaterials surface enabling the induction of tumor cell death is particularly desirable for implantable biomedical devices that directly contact tumor tissues. However, this specific antitumor feature is rarely found. Consequently, an antitumor‐cell nanocoating comprised of vanadium dioxide (VO2) prepared by customized reactive magnetron sputtering has been proposed, and its antitumor‐growth capability has been demonstrated using human cholangiocarcinoma cells. The results reveal that the VO2 nanocoating is able to interrupt the mitochondrial electron transport chain and then elevate the intracellular reactive oxygen species levels, leading to the collapse of the mitochondrial membrane potential and the destruction of cell redox homeostasis. Indeed, this chain reaction can effectively trigger oxidative damage in the cholangiocarcinoma cells. Additionally, this study has provided new insights into designing a tumor‐cell‐inhibited biomaterial surface, which is modulated by the mechanism of mitochondria‐targeting tumor cell death. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/20566646 | - |
dc.relation.ispartof | Global Challenges | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | anticancer | - |
dc.subject | charge transfer | - |
dc.subject | functional coatings and films | - |
dc.subject | mitochondria | - |
dc.subject | vanadium dioxide | - |
dc.title | Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption | - |
dc.type | Article | - |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | - |
dc.identifier.email | Yeung, KWK: wkkyeung@hku.hk | - |
dc.identifier.authority | Cheung, KMC=rp00387 | - |
dc.identifier.authority | Yeung, KWK=rp00309 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/gch2.201800058 | - |
dc.identifier.hkuros | 307079 | - |
dc.identifier.volume | 3 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | article no. 1800058 | - |
dc.identifier.epage | article no. 1800058 | - |
dc.identifier.isi | WOS:000460185600002 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 2056-6646 | - |