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Article: Nano Textured PEEK Surface for Enhanced Osseointegration

TitleNano Textured PEEK Surface for Enhanced Osseointegration
Authors
Keywordspolyetheretherketone
nanostructure
osseointegration
Issue Date2019
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/toc/abseba/current
Citation
ACS Biomaterials Science & Engineering, 2019, v. 5 n. 3, p. 1279-1289 How to Cite?
AbstractPolyetheretherketone (PEEK) is widely used in orthopedic and dental applications because of its similar mechanical properties to those of natural bones. However, the inferior osseointegration and bioinertness hamper the clinic application. The surface texture of biomaterials plays an essential role in controlling cell differentiation through affecting the cell-generated physical forces, thus improving the osseointegration of the substrate. In this work, argon PIII and subsequently hydrogen peroxide treatment are applied to construct the nanostructure on the PEEK surface. The in vitro results show that the cell adhesion, collagen secretion, and extracellular matrix (ECM) deposition can be enhanced on both nanostructured surfaces. The in vivo tests exhibit that the surface fabricated by physical-chemical treatment is more favorable for fibrous tissue filtration inhibition and osseointegration than that fabricated by argon PIII only. This work provides a candidate approach for improving the osseointegration ability of PEEK implant by constructing the nanostructure on its surface, which paves the way of applying PEEK in orthopedic and dental applications.
Persistent Identifierhttp://hdl.handle.net/10722/278233
ISSN
2017 Impact Factor: 4.432

 

DC FieldValueLanguage
dc.contributor.authorOUYANG, L-
dc.contributor.authorCHEN, M-
dc.contributor.authorWANG, D-
dc.contributor.authorLU, T-
dc.contributor.authorWANG, H-
dc.contributor.authorMENG, F-
dc.contributor.authorYANG, Y-
dc.contributor.authorMA, JZ-
dc.contributor.authorYeung, KWK-
dc.contributor.authorLIU, X-
dc.date.accessioned2019-10-04T08:10:03Z-
dc.date.available2019-10-04T08:10:03Z-
dc.date.issued2019-
dc.identifier.citationACS Biomaterials Science & Engineering, 2019, v. 5 n. 3, p. 1279-1289-
dc.identifier.issn2373-9878-
dc.identifier.urihttp://hdl.handle.net/10722/278233-
dc.description.abstractPolyetheretherketone (PEEK) is widely used in orthopedic and dental applications because of its similar mechanical properties to those of natural bones. However, the inferior osseointegration and bioinertness hamper the clinic application. The surface texture of biomaterials plays an essential role in controlling cell differentiation through affecting the cell-generated physical forces, thus improving the osseointegration of the substrate. In this work, argon PIII and subsequently hydrogen peroxide treatment are applied to construct the nanostructure on the PEEK surface. The in vitro results show that the cell adhesion, collagen secretion, and extracellular matrix (ECM) deposition can be enhanced on both nanostructured surfaces. The in vivo tests exhibit that the surface fabricated by physical-chemical treatment is more favorable for fibrous tissue filtration inhibition and osseointegration than that fabricated by argon PIII only. This work provides a candidate approach for improving the osseointegration ability of PEEK implant by constructing the nanostructure on its surface, which paves the way of applying PEEK in orthopedic and dental applications.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/toc/abseba/current-
dc.relation.ispartofACS Biomaterials Science & Engineering-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectpolyetheretherketone-
dc.subjectnanostructure-
dc.subjectosseointegration-
dc.titleNano Textured PEEK Surface for Enhanced Osseointegration-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsbiomaterials.8b01425-
dc.identifier.scopuseid_2-s2.0-85061897873-
dc.identifier.hkuros306958-
dc.identifier.volume5-
dc.identifier.issue3-
dc.identifier.spage1279-
dc.identifier.epage1289-
dc.publisher.placeUnited States-

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