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Article: Construction of perfluorohexane/IR780@liposome coating on Ti for rapid bacteria killing under permeable near infrared light

TitleConstruction of perfluorohexane/IR780@liposome coating on Ti for rapid bacteria killing under permeable near infrared light
Authors
KeywordsBiocompatibility
Enzyme inhibition
Escherichia coli
Irradiation
Oxygen
Issue Date2018
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all
Citation
Biomaterials Science, 2018, v. 6 n. 9, p. 2460-2471 How to Cite?
AbstractNear infrared (NIR) light induced photodynamic antibacterial therapy (PDAT) is a promising antibacterial technique in rapid in situ disinfection of bacterially infected artificial implants due to its penetration ability into tissues. However, the lower oxygen content in vivo may restrict the yields of reactive oxygen species (ROS), thus reducing the antibacterial efficacy of PADT significantly. Herein, liposome encapsulated photosensitizers (PS), IR780 and perfluorohexane (PFH), have been constructed on the surface of Ti implants via a covalent linkage to overcome this issue. Thanks to the high oxygen capacity of PFH, more ROS can be generated during NIR irradiation regardless of the low content of oxygen in vivo. As a result, in vitro tests demonstrated that 15 minutes of 808 nm near-infrared irradiation could achieve a high antibacterial efficacy of 99.62% and 99.63% on the implant surface against Escherichia coli and Staphylococcus aureus, respectively. By contrast, the PDAT system without PFH modification shows a lower antibacterial efficacy (only 66.54% and 48.04%, respectively). In addition, this enhanced PDAT system also possesses great biocompatibility based on the in vitro and in vivo subcutaneous assays. This surface system makes it possible for rapid bacteria-killing in artificial implants that have been implanted in vivo under local conditions with lower oxygen content.
Persistent Identifierhttp://hdl.handle.net/10722/278230
ISSN
2017 Impact Factor: 5.831
2015 SCImago Journal Rankings: 1.347

 

DC FieldValueLanguage
dc.contributor.authorWANG, X-
dc.contributor.authorTAN, L-
dc.contributor.authorLIU, X-
dc.contributor.authorCUI, Z-
dc.contributor.authorYANG, X-
dc.contributor.authorYeung, KWK-
dc.contributor.authorCHU, PK-
dc.contributor.authorWU, S-
dc.date.accessioned2019-10-04T08:09:59Z-
dc.date.available2019-10-04T08:09:59Z-
dc.date.issued2018-
dc.identifier.citationBiomaterials Science, 2018, v. 6 n. 9, p. 2460-2471-
dc.identifier.issn2047-4830-
dc.identifier.urihttp://hdl.handle.net/10722/278230-
dc.description.abstractNear infrared (NIR) light induced photodynamic antibacterial therapy (PDAT) is a promising antibacterial technique in rapid in situ disinfection of bacterially infected artificial implants due to its penetration ability into tissues. However, the lower oxygen content in vivo may restrict the yields of reactive oxygen species (ROS), thus reducing the antibacterial efficacy of PADT significantly. Herein, liposome encapsulated photosensitizers (PS), IR780 and perfluorohexane (PFH), have been constructed on the surface of Ti implants via a covalent linkage to overcome this issue. Thanks to the high oxygen capacity of PFH, more ROS can be generated during NIR irradiation regardless of the low content of oxygen in vivo. As a result, in vitro tests demonstrated that 15 minutes of 808 nm near-infrared irradiation could achieve a high antibacterial efficacy of 99.62% and 99.63% on the implant surface against Escherichia coli and Staphylococcus aureus, respectively. By contrast, the PDAT system without PFH modification shows a lower antibacterial efficacy (only 66.54% and 48.04%, respectively). In addition, this enhanced PDAT system also possesses great biocompatibility based on the in vitro and in vivo subcutaneous assays. This surface system makes it possible for rapid bacteria-killing in artificial implants that have been implanted in vivo under local conditions with lower oxygen content.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://pubs.rsc.org/en/Journals/JournalIssues/bm#!recentarticles&all-
dc.relation.ispartofBiomaterials Science-
dc.subjectBiocompatibility-
dc.subjectEnzyme inhibition-
dc.subjectEscherichia coli-
dc.subjectIrradiation-
dc.subjectOxygen-
dc.titleConstruction of perfluorohexane/IR780@liposome coating on Ti for rapid bacteria killing under permeable near infrared light-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/C8BM00602D-
dc.identifier.pmid30066710-
dc.identifier.scopuseid_2-s2.0-85052124357-
dc.identifier.hkuros306876-
dc.identifier.volume6-
dc.identifier.issue9-
dc.identifier.spage2460-
dc.identifier.epage2471-
dc.publisher.placeUnited Kingdom-

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