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Article: Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens

TitleBroad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens
Authors
Keywordsγδ T cell
MRSA
multivalent vaccine
Issue Date2019
PublisherAmerican Society for Microbiology: Open Access Journals. The Journal's web site is located at http://msphere.asm.org/
Citation
mSphere, 2019, v. 4 n. 5, p. article no. e00362-19 How to Cite?
AbstractThe demand for a prophylactic vaccine against methicillin-resistant Staphylococcus aureus (MRSA) has motivated numerous dedicated research groups to design and develop such a vaccine. In this study, we have developed a multivalent vaccine, Sta-V5, composed of five conserved antigens involved in three important virulence mechanisms. This prototype vaccine conferred up to 100% protection against multiple epidemiologically relevant S. aureus isolates in five different murine disease models. The vaccine not only elicits functional antibodies that mediate opsonophagocytic killing of S. aureus but also mounts robust antigen-specific T-cell responses. In addition, our data implied that γδ T cells contribute to the protection induced by Sta-V5 in a murine skin infection model.
Persistent Identifierhttp://hdl.handle.net/10722/278070
ISSN
2017 Impact Factor: 3.575
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorDENG, J-
dc.contributor.authorWang, X-
dc.contributor.authorZhang, BZ-
dc.contributor.authorGao, P-
dc.contributor.authorLin, Q-
dc.contributor.authorKao, RYT-
dc.contributor.authorGustafsson, K-
dc.contributor.authorYuen, KY-
dc.contributor.authorHuang, JD-
dc.date.accessioned2019-10-04T08:06:55Z-
dc.date.available2019-10-04T08:06:55Z-
dc.date.issued2019-
dc.identifier.citationmSphere, 2019, v. 4 n. 5, p. article no. e00362-19-
dc.identifier.issn2379-5042-
dc.identifier.urihttp://hdl.handle.net/10722/278070-
dc.description.abstractThe demand for a prophylactic vaccine against methicillin-resistant Staphylococcus aureus (MRSA) has motivated numerous dedicated research groups to design and develop such a vaccine. In this study, we have developed a multivalent vaccine, Sta-V5, composed of five conserved antigens involved in three important virulence mechanisms. This prototype vaccine conferred up to 100% protection against multiple epidemiologically relevant S. aureus isolates in five different murine disease models. The vaccine not only elicits functional antibodies that mediate opsonophagocytic killing of S. aureus but also mounts robust antigen-specific T-cell responses. In addition, our data implied that γδ T cells contribute to the protection induced by Sta-V5 in a murine skin infection model.-
dc.languageeng-
dc.publisherAmerican Society for Microbiology: Open Access Journals. The Journal's web site is located at http://msphere.asm.org/-
dc.relation.ispartofmSphere-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectγδ T cell-
dc.subjectMRSA-
dc.subjectmultivalent vaccine-
dc.titleBroad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens-
dc.typeArticle-
dc.identifier.emailWang, X: xiaoleiw@hku.hk-
dc.identifier.emailGao, P: gaopeng@hku.hk-
dc.identifier.emailLin, Q: qiubin@hku.hk-
dc.identifier.emailKao, RYT: rytkao@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailHuang, JD: jdhuang@hku.hk-
dc.identifier.authorityKao, RYT=rp00481-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityHuang, JD=rp00451-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1128/mSphere.00362-19-
dc.identifier.pmid31484738-
dc.identifier.pmcidPMC6731528-
dc.identifier.scopuseid_2-s2.0-85071737092-
dc.identifier.hkuros306881-
dc.identifier.volume4-
dc.identifier.issue5-
dc.identifier.spagearticle no. e00362-
dc.identifier.epage19-
dc.publisher.placeUnited States-

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