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Article: Spexin acts as novel regulator for bile acid synthesis

TitleSpexin acts as novel regulator for bile acid synthesis
Authors
Keywordsbile acid
CYP7A1
spexin
ultraperformance liquid chromatography mass spectrometry
metabolism
Issue Date2018
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/physiology/
Citation
Frontiers in Physiology, 2018, v. 9, p. article no. 378 How to Cite?
AbstractSpexin is a novel hormone involved in obesity and diabetes while its biofunctional significance in lipid metabolism is still to be comprehended. Global metabolomic analysis in the present study revealed multiple metabolic pathways altered by spexin intraperitoneal (i.p.) injection in rat serum, which are highlighted by the changes in several bile acid metabolites. In rats, spexin (300 μg/kg) could dramatically reduce hepatic and circulating total bile acids (TBA) level compared with the controls. Correspondingly, treatment with spexin by i.p. injection for 28 days led to significant decrease in serum TBA and gallbladder weight in C57BL/6J mice. In enterohepatic circulation system, spexin effectively reduced TBA levels in mouse liver and gallbladder but not the intestine. Hepatic cholesterol 7α-hydroxylase 1 (CYP7A1) expression, unsurprisingly, was suppressed by spexin injection. Both GALR2 and GALR3 antagonists reversed the inhibitory effects of spexin on concentrations of serum TBA and 7 α-hydroxy-4-cholesten-3-one (C4), and hepatic CYP7A1 expression. Finally, negative correlations were observed between serum spexin and total cholesterol (TC), total bile acid (TBA), tauro-chenodeoxycholate (TCDCA), as well as glycochenodeoxycholate (GCDCA) in 91 healthy volunteers. These findings illuminate the intrinsic importance of spexin in the regulation of bile acid synthesis and metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/278020
ISSN
2017 Impact Factor: 3.394
2015 SCImago Journal Rankings: 1.840
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLin, CY-
dc.contributor.authorZhao, L-
dc.contributor.authorHuang, T-
dc.contributor.authorLu, L-
dc.contributor.authorKhan, M-
dc.contributor.authorLiu, J-
dc.contributor.authorZhong, LLD-
dc.contributor.authorCai, ZW-
dc.contributor.authorFan, BM-
dc.contributor.authorWong, AOL-
dc.contributor.authorBian, ZX-
dc.date.accessioned2019-10-04T08:05:53Z-
dc.date.available2019-10-04T08:05:53Z-
dc.date.issued2018-
dc.identifier.citationFrontiers in Physiology, 2018, v. 9, p. article no. 378-
dc.identifier.issn1664-042X-
dc.identifier.urihttp://hdl.handle.net/10722/278020-
dc.description.abstractSpexin is a novel hormone involved in obesity and diabetes while its biofunctional significance in lipid metabolism is still to be comprehended. Global metabolomic analysis in the present study revealed multiple metabolic pathways altered by spexin intraperitoneal (i.p.) injection in rat serum, which are highlighted by the changes in several bile acid metabolites. In rats, spexin (300 μg/kg) could dramatically reduce hepatic and circulating total bile acids (TBA) level compared with the controls. Correspondingly, treatment with spexin by i.p. injection for 28 days led to significant decrease in serum TBA and gallbladder weight in C57BL/6J mice. In enterohepatic circulation system, spexin effectively reduced TBA levels in mouse liver and gallbladder but not the intestine. Hepatic cholesterol 7α-hydroxylase 1 (CYP7A1) expression, unsurprisingly, was suppressed by spexin injection. Both GALR2 and GALR3 antagonists reversed the inhibitory effects of spexin on concentrations of serum TBA and 7 α-hydroxy-4-cholesten-3-one (C4), and hepatic CYP7A1 expression. Finally, negative correlations were observed between serum spexin and total cholesterol (TC), total bile acid (TBA), tauro-chenodeoxycholate (TCDCA), as well as glycochenodeoxycholate (GCDCA) in 91 healthy volunteers. These findings illuminate the intrinsic importance of spexin in the regulation of bile acid synthesis and metabolism.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/physiology/-
dc.relation.ispartofFrontiers in Physiology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbile acid-
dc.subjectCYP7A1-
dc.subjectspexin-
dc.subjectultraperformance liquid chromatography mass spectrometry-
dc.subjectmetabolism-
dc.titleSpexin acts as novel regulator for bile acid synthesis-
dc.typeArticle-
dc.identifier.emailWong, AOL: olwong@hku.hk-
dc.identifier.authorityWong, AOL=rp00806-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fphys.2018.00378-
dc.identifier.pmid29692737-
dc.identifier.pmcidPMC5902714-
dc.identifier.scopuseid_2-s2.0-85045238913-
dc.identifier.hkuros306562-
dc.identifier.volume9-
dc.identifier.spagearticle no. 378-
dc.identifier.epagearticle no. 378-
dc.publisher.placeSwitzerland-

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