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Article: Rapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid‐Conjugated PDA Hydrogel through Dual‐Light Triggered ROS and Membrane Permeability

TitleRapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid‐Conjugated PDA Hydrogel through Dual‐Light Triggered ROS and Membrane Permeability
Authors
Keywordsantibacterial
carbon quantum dots
hydrogel
phototherapy
wound healing
Issue Date2019
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jabout/107640323/2421_info.html
Citation
Small, 2019, v. 15 n. 22, p. article no. 1900322 How to Cite?
AbstractOne of the most difficult challenges in the biomedical field is bacterial infection, which causes tremendous harm to human health. In this work, an injectable hydrogel is synthesized through rapid assembly of dopamine (DA) and folic acid (FA) cross‐linked by transition metal ions (TMIs, i.e., Zn2+), which was named as DFT‐hydrogel. Both the two carboxyl groups in the FA molecule and catechol in polydopamine (PDA) easily chelates Zn2+ to form metal–ligand coordination, thereby allowing this injectable hydrogel to match the shapes of wounds. In addition, PDA in the hydrogel coated around carbon quantum dot‐decorated ZnO (C/ZnO) nanoparticles (NPs) to rapidly generate reactive oxygen species (ROS) and heat under illumination with 660 and 808 nm light, endows this hybrid hydrogel with great antibacterial efficacy against Staphylococcus aureus (S. aureus, typical Gram‐positive bacteria) and Escherichia coli (E. coli, typical Gram‐negative bacteria). The antibacterial efficacy of the prepared DFT‐C/ZnO‐hydrogel against S. aureus and E. coli under dual‐light irradiation is 99.9%. Importantly, the hydrogels release zinc ions over 12 days, resulting in a sustained antimicrobial effect and promoted fibroblast growth. Thus, this hybrid hydrogel exhibits great potential for the reconstruction of bacteria‐infected tissues, especially exposed wounds.
Persistent Identifierhttp://hdl.handle.net/10722/277994
ISSN
2017 Impact Factor: 9.598
2015 SCImago Journal Rankings: 3.401

 

DC FieldValueLanguage
dc.contributor.authorXIANG, Y-
dc.contributor.authorMAO, C-
dc.contributor.authorLIU, X-
dc.contributor.authorCUI, Z-
dc.contributor.authorJING, D-
dc.contributor.authorYANG, X-
dc.contributor.authorLIANG, Y-
dc.contributor.authorLI, Z-
dc.contributor.authorZHU, S-
dc.contributor.authorZHENG, Y-
dc.contributor.authorYeung, KWK-
dc.contributor.authorZHENG, D-
dc.contributor.authorWANG, X-
dc.contributor.authorWU, S-
dc.date.accessioned2019-10-04T08:05:22Z-
dc.date.available2019-10-04T08:05:22Z-
dc.date.issued2019-
dc.identifier.citationSmall, 2019, v. 15 n. 22, p. article no. 1900322-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/277994-
dc.description.abstractOne of the most difficult challenges in the biomedical field is bacterial infection, which causes tremendous harm to human health. In this work, an injectable hydrogel is synthesized through rapid assembly of dopamine (DA) and folic acid (FA) cross‐linked by transition metal ions (TMIs, i.e., Zn2+), which was named as DFT‐hydrogel. Both the two carboxyl groups in the FA molecule and catechol in polydopamine (PDA) easily chelates Zn2+ to form metal–ligand coordination, thereby allowing this injectable hydrogel to match the shapes of wounds. In addition, PDA in the hydrogel coated around carbon quantum dot‐decorated ZnO (C/ZnO) nanoparticles (NPs) to rapidly generate reactive oxygen species (ROS) and heat under illumination with 660 and 808 nm light, endows this hybrid hydrogel with great antibacterial efficacy against Staphylococcus aureus (S. aureus, typical Gram‐positive bacteria) and Escherichia coli (E. coli, typical Gram‐negative bacteria). The antibacterial efficacy of the prepared DFT‐C/ZnO‐hydrogel against S. aureus and E. coli under dual‐light irradiation is 99.9%. Importantly, the hydrogels release zinc ions over 12 days, resulting in a sustained antimicrobial effect and promoted fibroblast growth. Thus, this hybrid hydrogel exhibits great potential for the reconstruction of bacteria‐infected tissues, especially exposed wounds.-
dc.languageeng-
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jabout/107640323/2421_info.html-
dc.relation.ispartofSmall-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectantibacterial-
dc.subjectcarbon quantum dots-
dc.subjecthydrogel-
dc.subjectphototherapy-
dc.subjectwound healing-
dc.titleRapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid‐Conjugated PDA Hydrogel through Dual‐Light Triggered ROS and Membrane Permeability-
dc.typeArticle-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/smll.201900322-
dc.identifier.pmid31021489-
dc.identifier.scopuseid_2-s2.0-85065044025-
dc.identifier.hkuros306974-
dc.identifier.volume15-
dc.identifier.issue22-
dc.identifier.spagearticle no. 1900322-
dc.identifier.epagearticle no. 1900322-
dc.publisher.placeGermany-

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