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- Publisher Website: 10.1016/j.ejogrb.2013.02.001
- Scopus: eid_2-s2.0-84879124043
- PMID: 23465469
- WOS: WOS:000321539300003
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Article: Towards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy
Title | Towards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy |
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Authors | |
Keywords | Hepatitis B virus Pregnancy Infection transmission Maternal–foetal Antiviral agent |
Issue Date | 2013 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb |
Citation | European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013, v. 169 n. 1, p. 17-23 How to Cite? |
Abstract | Hepatitis B infection remains the most common form of chronic hepatitis. Mother to child transmission occurs despite immunoprophylaxis with vaccination and immunoglobulin. In utero infection is suggested to account for most of the cases with immunoprophylaxis failure. Infants who suffer from hepatitis B infection at birth have a higher risk of becoming chronic carriers and may develop liver cirrhosis or hepatocellular carcinoma in the future. Infected germ cells, transplacental infection, invasive prenatal diagnostic tests and various perinatal factors are possible factors leading to in utero infection and subsequent immunoprophylaxis failure. Hepatitis B e antigen positive status and high viral load increase the risk of immunoprophylaxis failure. Recent evidence shows promising results regarding the use of antiviral treatment in late gestation to suppress viral load, so as to decrease the risk of vertical transmission. This review discusses the possible mechanisms of in utero infection and the use of antiviral treatment during pregnancy. |
Persistent Identifier | http://hdl.handle.net/10722/277770 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.780 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheung, KW | - |
dc.contributor.author | Seto, MTY | - |
dc.contributor.author | Wong, SF | - |
dc.date.accessioned | 2019-10-04T08:01:00Z | - |
dc.date.available | 2019-10-04T08:01:00Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013, v. 169 n. 1, p. 17-23 | - |
dc.identifier.issn | 0301-2115 | - |
dc.identifier.uri | http://hdl.handle.net/10722/277770 | - |
dc.description.abstract | Hepatitis B infection remains the most common form of chronic hepatitis. Mother to child transmission occurs despite immunoprophylaxis with vaccination and immunoglobulin. In utero infection is suggested to account for most of the cases with immunoprophylaxis failure. Infants who suffer from hepatitis B infection at birth have a higher risk of becoming chronic carriers and may develop liver cirrhosis or hepatocellular carcinoma in the future. Infected germ cells, transplacental infection, invasive prenatal diagnostic tests and various perinatal factors are possible factors leading to in utero infection and subsequent immunoprophylaxis failure. Hepatitis B e antigen positive status and high viral load increase the risk of immunoprophylaxis failure. Recent evidence shows promising results regarding the use of antiviral treatment in late gestation to suppress viral load, so as to decrease the risk of vertical transmission. This review discusses the possible mechanisms of in utero infection and the use of antiviral treatment during pregnancy. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb | - |
dc.relation.ispartof | European Journal of Obstetrics & Gynecology and Reproductive Biology | - |
dc.subject | Hepatitis B virus | - |
dc.subject | Pregnancy | - |
dc.subject | Infection transmission | - |
dc.subject | Maternal–foetal | - |
dc.subject | Antiviral agent | - |
dc.title | Towards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy | - |
dc.type | Article | - |
dc.identifier.email | Cheung, KW: kawang@HKUCC-COM.hku.hk | - |
dc.identifier.email | Seto, MTY: mimiseto@HKUCC-COM.hku.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ejogrb.2013.02.001 | - |
dc.identifier.pmid | 23465469 | - |
dc.identifier.scopus | eid_2-s2.0-84879124043 | - |
dc.identifier.hkuros | 306676 | - |
dc.identifier.volume | 169 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 17 | - |
dc.identifier.epage | 23 | - |
dc.identifier.isi | WOS:000321539300003 | - |
dc.publisher.place | Ireland | - |
dc.identifier.issnl | 0301-2115 | - |