File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Towards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy

TitleTowards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy
Authors
KeywordsHepatitis B virus
Pregnancy
Infection transmission
Maternal–foetal
Antiviral agent
Issue Date2013
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
Citation
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013, v. 169 n. 1, p. 17-23 How to Cite?
AbstractHepatitis B infection remains the most common form of chronic hepatitis. Mother to child transmission occurs despite immunoprophylaxis with vaccination and immunoglobulin. In utero infection is suggested to account for most of the cases with immunoprophylaxis failure. Infants who suffer from hepatitis B infection at birth have a higher risk of becoming chronic carriers and may develop liver cirrhosis or hepatocellular carcinoma in the future. Infected germ cells, transplacental infection, invasive prenatal diagnostic tests and various perinatal factors are possible factors leading to in utero infection and subsequent immunoprophylaxis failure. Hepatitis B e antigen positive status and high viral load increase the risk of immunoprophylaxis failure. Recent evidence shows promising results regarding the use of antiviral treatment in late gestation to suppress viral load, so as to decrease the risk of vertical transmission. This review discusses the possible mechanisms of in utero infection and the use of antiviral treatment during pregnancy.
Persistent Identifierhttp://hdl.handle.net/10722/277770
ISSN
2017 Impact Factor: 1.809
2015 SCImago Journal Rankings: 0.808

 

DC FieldValueLanguage
dc.contributor.authorCheung, KW-
dc.contributor.authorSeto, MTY-
dc.contributor.authorWong, SF-
dc.date.accessioned2019-10-04T08:01:00Z-
dc.date.available2019-10-04T08:01:00Z-
dc.date.issued2013-
dc.identifier.citationEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2013, v. 169 n. 1, p. 17-23-
dc.identifier.issn0301-2115-
dc.identifier.urihttp://hdl.handle.net/10722/277770-
dc.description.abstractHepatitis B infection remains the most common form of chronic hepatitis. Mother to child transmission occurs despite immunoprophylaxis with vaccination and immunoglobulin. In utero infection is suggested to account for most of the cases with immunoprophylaxis failure. Infants who suffer from hepatitis B infection at birth have a higher risk of becoming chronic carriers and may develop liver cirrhosis or hepatocellular carcinoma in the future. Infected germ cells, transplacental infection, invasive prenatal diagnostic tests and various perinatal factors are possible factors leading to in utero infection and subsequent immunoprophylaxis failure. Hepatitis B e antigen positive status and high viral load increase the risk of immunoprophylaxis failure. Recent evidence shows promising results regarding the use of antiviral treatment in late gestation to suppress viral load, so as to decrease the risk of vertical transmission. This review discusses the possible mechanisms of in utero infection and the use of antiviral treatment during pregnancy.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb-
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology-
dc.subjectHepatitis B virus-
dc.subjectPregnancy-
dc.subjectInfection transmission-
dc.subjectMaternal–foetal-
dc.subjectAntiviral agent-
dc.titleTowards complete eradication of hepatitis B infection from perinatal transmission: review of the mechanisms of in utero infection and the use of antiviral treatment during pregnancy-
dc.typeArticle-
dc.identifier.emailCheung, KW: kawang@HKUCC-COM.hku.hk-
dc.identifier.emailSeto, MTY: mimiseto@HKUCC-COM.hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejogrb.2013.02.001-
dc.identifier.pmid23465469-
dc.identifier.scopuseid_2-s2.0-84879124043-
dc.identifier.hkuros306676-
dc.identifier.volume169-
dc.identifier.issue1-
dc.identifier.spage17-
dc.identifier.epage23-
dc.publisher.placeIreland-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats