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Article: Dual-comb spectrally encoded confocal microscopy by electro-optic modulators

TitleDual-comb spectrally encoded confocal microscopy by electro-optic modulators
Authors
KeywordsAnalytic equipment
Confocal microscopy
Light modulation
Modulators
Issue Date2019
PublisherOptical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3
Citation
Optics Letters, 2019, v. 44 n. 11, p. 2919-2922 How to Cite?
AbstractWe demonstrate an electro-optic (EO) based dual-comb spectrally encoded confocal microscopy (DC-SECM). With the capability of large comb spacing (∼8.1-GHz) and comb-line to pixel mapping, only thirteen comb lines are used to sample a spatial point of resolution size. Such spatial sampling effectively lessens the required average focal power for a given signal-to-noise ratio (SNR) and contributes to a higher power-efficiency, which alleviates the risk of photodamage. Furthermore, the tunable beating frequency (0–6 MHz) of dual comb interferometry (DCI) renders an achievable ultrafast imaging speed up to MHz level. The image performance was evaluated using a standard resolution target, indicating a lateral resolution of 2.76-μm, and further demonstrated with biological samples. Compared with time-stretch spectrally-encoded microscopy, the DC-SECM can not only achieve low-focal-power (∼30  μW) imaging but also function under minimum settings of both electrical bandwidth (hundreds-of MHz) and digitization sampling rate (1 Gs/s), while simultaneously maintaining a frame rate on the order of MHz.
Persistent Identifierhttp://hdl.handle.net/10722/277231
ISSN
2017 Impact Factor: 3.589
2015 SCImago Journal Rankings: 2.397

 

DC FieldValueLanguage
dc.contributor.authorFENG, P-
dc.contributor.authorKANG, J-
dc.contributor.authorTAN, S-
dc.contributor.authorRen, YX-
dc.contributor.authorZhang, C-
dc.contributor.authorWong, KKY-
dc.date.accessioned2019-09-20T08:47:06Z-
dc.date.available2019-09-20T08:47:06Z-
dc.date.issued2019-
dc.identifier.citationOptics Letters, 2019, v. 44 n. 11, p. 2919-2922-
dc.identifier.issn0146-9592-
dc.identifier.urihttp://hdl.handle.net/10722/277231-
dc.description.abstractWe demonstrate an electro-optic (EO) based dual-comb spectrally encoded confocal microscopy (DC-SECM). With the capability of large comb spacing (∼8.1-GHz) and comb-line to pixel mapping, only thirteen comb lines are used to sample a spatial point of resolution size. Such spatial sampling effectively lessens the required average focal power for a given signal-to-noise ratio (SNR) and contributes to a higher power-efficiency, which alleviates the risk of photodamage. Furthermore, the tunable beating frequency (0–6 MHz) of dual comb interferometry (DCI) renders an achievable ultrafast imaging speed up to MHz level. The image performance was evaluated using a standard resolution target, indicating a lateral resolution of 2.76-μm, and further demonstrated with biological samples. Compared with time-stretch spectrally-encoded microscopy, the DC-SECM can not only achieve low-focal-power (∼30  μW) imaging but also function under minimum settings of both electrical bandwidth (hundreds-of MHz) and digitization sampling rate (1 Gs/s), while simultaneously maintaining a frame rate on the order of MHz.-
dc.languageeng-
dc.publisherOptical Society of America. The Journal's web site is located at http://www.opticsinfobase.org/current.cfm?journal=3-
dc.relation.ispartofOptics Letters-
dc.rightsOptics Letters. Copyright © Optical Society of America.-
dc.rights© XXXX [year] Optical Society of America]. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited.-
dc.subjectAnalytic equipment-
dc.subjectConfocal microscopy-
dc.subjectLight modulation-
dc.subjectModulators-
dc.titleDual-comb spectrally encoded confocal microscopy by electro-optic modulators-
dc.typeArticle-
dc.identifier.emailRen, YX: yxren@hku.hk-
dc.identifier.emailWong, KKY: kywong@eee.hku.hk-
dc.identifier.authorityWong, KKY=rp00189-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1364/OL.44.002919-
dc.identifier.scopuseid_2-s2.0-85066445244-
dc.identifier.hkuros305775-
dc.identifier.volume44-
dc.identifier.issue11-
dc.identifier.spage2919-
dc.identifier.epage2922-
dc.publisher.placeUnited States-

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