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- Publisher Website: 10.1021/jacs.6b08942
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Article: Ligand-Promoted meta-C-H Amination and Alkynylation
Title | Ligand-Promoted meta-C-H Amination and Alkynylation |
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Authors | |
Issue Date | 2016 |
Citation | Journal of the American Chemical Society, 2016, v. 138, n. 42, p. 14092-14099 How to Cite? |
Abstract | © 2016 American Chemical Society. Using a modified norbornene (methyl bicyclo[2.2.1]hept-2-ene-2-carboxylate) as a transient mediator, meta-C-H amination and meta-C-H alkynylation of aniline and phenol substrates have been developed for the first time. Both the identification of a monoprotected 3-amino-2-hydroxypyridine/pyridone-type ligand and the use of a modified norbornene as a mediator are crucial for the realization of these two unprecedented meta-C-H transformations. A variety of substrates are compatible with both meta-C-H amination and meta-C-H alkynylation. Amination and alkynylation of heterocyclic substrates including indole, indoline, and indazole afford the desired products in moderate to high yields. |
Persistent Identifier | http://hdl.handle.net/10722/277037 |
ISSN | 2021 Impact Factor: 16.383 2020 SCImago Journal Rankings: 7.115 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Peng | - |
dc.contributor.author | Li, Gen Cheng | - |
dc.contributor.author | Jain, Pankaj | - |
dc.contributor.author | Farmer, Marcus E. | - |
dc.contributor.author | He, Jian | - |
dc.contributor.author | Shen, Peng Xiang | - |
dc.contributor.author | Yu, Jin Quan | - |
dc.date.accessioned | 2019-09-18T08:35:24Z | - |
dc.date.available | 2019-09-18T08:35:24Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2016, v. 138, n. 42, p. 14092-14099 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/277037 | - |
dc.description.abstract | © 2016 American Chemical Society. Using a modified norbornene (methyl bicyclo[2.2.1]hept-2-ene-2-carboxylate) as a transient mediator, meta-C-H amination and meta-C-H alkynylation of aniline and phenol substrates have been developed for the first time. Both the identification of a monoprotected 3-amino-2-hydroxypyridine/pyridone-type ligand and the use of a modified norbornene as a mediator are crucial for the realization of these two unprecedented meta-C-H transformations. A variety of substrates are compatible with both meta-C-H amination and meta-C-H alkynylation. Amination and alkynylation of heterocyclic substrates including indole, indoline, and indazole afford the desired products in moderate to high yields. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.title | Ligand-Promoted meta-C-H Amination and Alkynylation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/jacs.6b08942 | - |
dc.identifier.scopus | eid_2-s2.0-84992752883 | - |
dc.identifier.volume | 138 | - |
dc.identifier.issue | 42 | - |
dc.identifier.spage | 14092 | - |
dc.identifier.epage | 14099 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.isi | WOS:000386540500052 | - |
dc.identifier.issnl | 0002-7863 | - |