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Conference Paper: Catheter based Radiofrequency Renal Denervation Decreases Renal Norepinephrine Spillover and Improve Cardiac Contractile Function in Porcine Model of Ischemic heart failure

TitleCatheter based Radiofrequency Renal Denervation Decreases Renal Norepinephrine Spillover and Improve Cardiac Contractile Function in Porcine Model of Ischemic heart failure
Authors
Issue Date2015
PublisherAmerican Heart Association. The Journal's web site is located at http://circ.ahajournals.org
Citation
American Heart Association Scientific Sessions 2015, Orlando, USA, 7-11 November 2015. Abstracts in Circulation, 2015, v. 132 n. Suppl. 3, Abstract 17410 How to Cite?
AbstractBackground: Catheter-based radiofrequency (RF) renal denervation (RD) has been shown to decrease renal norepinephrine (NE) spillover in animal models and humans with hypertension. Nevertheless, the effect of RD on renal NE spillover in systolic heart failure (HF) is unknown. Methods: Ischemic HF model was created in 16 porcine by inducing myocardial infarction (MI) via coronary embolization of the left circumflex artery followed by rapid ventricular pacing for 4 weeks (MI+HF). Of these, 8 porcine underwent bilateral RD using the EnligHTN System (St. Jude Medical) and the remaining 8 served as control. All animals were given daily oral metoprolol ZOK (50 mg) plus ramipril (2.5 mg). Serum NE levels at different sites and index of cardiac contractility (dP/dtmax/IP) were measured at baseline, immediately after MI (post-MI), at MI+HF and at 10 weeks follow-up. Renal arteries were then prepared for histological analysis. Results: RD significantly increased the dP/dtmax/IP as compared with the control group (P<0.05, Figure 1a). RD also decreased the arterial and coronary sinus NE (P<0.05), and renal NE spillover (-54%, P=0.06) at 10 weeks as compared with MI+HF (Figures 1b & 1c). Histological examination showed significant reduction of renal sympathetic efferent nerves (tyrosine hydroxylase+) at proximal, middle and distal portions of the renal artery after RD as compared with the control group (-65%, P<0.05, Figure 1d). Conclusions: In a porcine model of ischemic HF, bilateral RD using catheter-based RF effectively destroys renal nerves to decrease renal NE spillover, and improves LV contractile function compared with medical therapy alone.
DescriptionInvited Speaker - Imaging: Session Title: Imaging Myocardial and Left Ventricular Function
Persistent Identifierhttp://hdl.handle.net/10722/276438
ISSN
2017 Impact Factor: 18.881
2015 SCImago Journal Rankings: 7.853

 

DC FieldValueLanguage
dc.contributor.authorTse, HF-
dc.contributor.authorLiao, S-
dc.contributor.authorZhu, Z-
dc.contributor.authorZhen, Z-
dc.contributor.authorDeRama, R-
dc.contributor.authorHata, C-
dc.contributor.authorChen, P-
dc.date.accessioned2019-09-10T09:09:54Z-
dc.date.available2019-09-10T09:09:54Z-
dc.date.issued2015-
dc.identifier.citationAmerican Heart Association Scientific Sessions 2015, Orlando, USA, 7-11 November 2015. Abstracts in Circulation, 2015, v. 132 n. Suppl. 3, Abstract 17410-
dc.identifier.issn0009-7322-
dc.identifier.urihttp://hdl.handle.net/10722/276438-
dc.descriptionInvited Speaker - Imaging: Session Title: Imaging Myocardial and Left Ventricular Function-
dc.description.abstractBackground: Catheter-based radiofrequency (RF) renal denervation (RD) has been shown to decrease renal norepinephrine (NE) spillover in animal models and humans with hypertension. Nevertheless, the effect of RD on renal NE spillover in systolic heart failure (HF) is unknown. Methods: Ischemic HF model was created in 16 porcine by inducing myocardial infarction (MI) via coronary embolization of the left circumflex artery followed by rapid ventricular pacing for 4 weeks (MI+HF). Of these, 8 porcine underwent bilateral RD using the EnligHTN System (St. Jude Medical) and the remaining 8 served as control. All animals were given daily oral metoprolol ZOK (50 mg) plus ramipril (2.5 mg). Serum NE levels at different sites and index of cardiac contractility (dP/dtmax/IP) were measured at baseline, immediately after MI (post-MI), at MI+HF and at 10 weeks follow-up. Renal arteries were then prepared for histological analysis. Results: RD significantly increased the dP/dtmax/IP as compared with the control group (P<0.05, Figure 1a). RD also decreased the arterial and coronary sinus NE (P<0.05), and renal NE spillover (-54%, P=0.06) at 10 weeks as compared with MI+HF (Figures 1b & 1c). Histological examination showed significant reduction of renal sympathetic efferent nerves (tyrosine hydroxylase+) at proximal, middle and distal portions of the renal artery after RD as compared with the control group (-65%, P<0.05, Figure 1d). Conclusions: In a porcine model of ischemic HF, bilateral RD using catheter-based RF effectively destroys renal nerves to decrease renal NE spillover, and improves LV contractile function compared with medical therapy alone.-
dc.languageeng-
dc.publisherAmerican Heart Association. The Journal's web site is located at http://circ.ahajournals.org-
dc.relation.ispartofCirculation-
dc.relation.ispartofAmerican Heart Association Scientific Sessions 2015-
dc.titleCatheter based Radiofrequency Renal Denervation Decreases Renal Norepinephrine Spillover and Improve Cardiac Contractile Function in Porcine Model of Ischemic heart failure-
dc.typeConference_Paper-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailLiao, S: lsy923@hkucc.hku.hk-
dc.identifier.emailZhen, Z: zhenzhe@hku.hk-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityLiao, S=rp02244-
dc.identifier.hkuros260268-
dc.identifier.volume132-
dc.identifier.issueSuppl. 3-
dc.identifier.spageAbstract 17410-
dc.identifier.epageAbstract 17410-
dc.publisher.placeUnited States-

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