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Article: SOX17 in cellular reprogramming and cancer

TitleSOX17 in cellular reprogramming and cancer
Authors
KeywordsCancer
Cellular reprogramming
SOX17
WNT signaling
β-catenin
Issue Date2019
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
Citation
Seminars in Cancer Biology, 2019, Epub How to Cite?
AbstractSOX17 is a transcription factor directing the specification and development of the primitive endoderm, primitive germ cells, definitive endoderm and, subsequently, is involved in the cardiovascular system and several endoderm-derived organs. The analysis of cancer genome sequencing data classified SOX17 as mutated cancer driver gene in endometrial cancer. These studies identified hotspot missense mutations within its DNA binding and transactivation domains. In somatic cell reprogramming, structure-based protein re-engineering showed a single missense mutation in SOX17 can change the DNA dependent heterodimer formation with OCT4 and enables the replacement of SOX2 with SOX17 mutants to induce pluripotency. This reveals the profound impact of specific missense mutations on gene function and regulatory activity. Here, we review the roles of SOX17 in cancer and discuss its cross-talk with the WNT/β-catenin pathway, potentially reconciling its activity as re-engineered reprogramming factor and mutated cancer driver gene. © 2019 Elsevier Ltd
Persistent Identifierhttp://hdl.handle.net/10722/276217
ISSN
2019 Impact Factor: 11.09
2015 SCImago Journal Rankings: 6.320

 

DC FieldValueLanguage
dc.contributor.authorTan, DS-
dc.contributor.authorHolzner, M-
dc.contributor.authorWeng, M-
dc.contributor.authorSrivastava, Y-
dc.contributor.authorJauch, R-
dc.date.accessioned2019-09-10T02:58:22Z-
dc.date.available2019-09-10T02:58:22Z-
dc.date.issued2019-
dc.identifier.citationSeminars in Cancer Biology, 2019, Epub-
dc.identifier.issn1044-579X-
dc.identifier.urihttp://hdl.handle.net/10722/276217-
dc.description.abstractSOX17 is a transcription factor directing the specification and development of the primitive endoderm, primitive germ cells, definitive endoderm and, subsequently, is involved in the cardiovascular system and several endoderm-derived organs. The analysis of cancer genome sequencing data classified SOX17 as mutated cancer driver gene in endometrial cancer. These studies identified hotspot missense mutations within its DNA binding and transactivation domains. In somatic cell reprogramming, structure-based protein re-engineering showed a single missense mutation in SOX17 can change the DNA dependent heterodimer formation with OCT4 and enables the replacement of SOX2 with SOX17 mutants to induce pluripotency. This reveals the profound impact of specific missense mutations on gene function and regulatory activity. Here, we review the roles of SOX17 in cancer and discuss its cross-talk with the WNT/β-catenin pathway, potentially reconciling its activity as re-engineered reprogramming factor and mutated cancer driver gene. © 2019 Elsevier Ltd-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer-
dc.relation.ispartofSeminars in Cancer Biology-
dc.subjectCancer-
dc.subjectCellular reprogramming-
dc.subjectSOX17-
dc.subjectWNT signaling-
dc.subjectβ-catenin-
dc.titleSOX17 in cellular reprogramming and cancer-
dc.typeArticle-
dc.identifier.emailJauch, R: ralf@hku.hk-
dc.identifier.authorityJauch, R=rp02383-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.semcancer.2019.08.008-
dc.identifier.scopuseid_2-s2.0-85070866369-
dc.identifier.scopuseid_2-s2.0-85070866369-
dc.identifier.hkuros302724-
dc.publisher.placeUnited Kingdom-

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