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Article: Bacteriophage of the Skin Microbiome in Patients with Psoriasis and Healthy Family Controls

TitleBacteriophage of the Skin Microbiome in Patients with Psoriasis and Healthy Family Controls
Authors
Issue Date2019
PublisherElsevier Ltd. The Journal's web site is located at https://www.journals.elsevier.com/journal-of-investigative-dermatology
Citation
The Journal of Investigative Dermatology, 2019 How to Cite?
AbstractThe bacteriophage (phage) component of the skin microbiome in patients with psoriasis has not been systematically explored. The purpose of this study is to investigate phage and bacterial components of the skin microbiome in patients with psoriasis and in healthy family controls. Lesional skin swabs of four different locations (elbow, forearm, knee, and scalp) were taken from patients with psoriasis. Healthy skin swabs of matched locations were taken from contralateral non-lesional skin and healthy family controls. Skin microbiomes were investigated using next-generation shotgun metagenomics sequencing. 81 skin microbiome samples (27 lesional skin samples and 54 healthy skin samples from contralateral non-lesional skin and family controls) obtained from 16 subjects with psoriasis and 16 matched family controls were sequenced and analyzed. Among phage species with abundant host bacteria, two significantly differential abundant phage species, Acinetobacter phage Presley and Pseudomonas phage O4 (adjusted P < 0.05), between psoriasis lesional skin and healthy skin were identified. Samples with high levels of these phage species had their host bacteria abundance suppressed (P = 0.03 and P < 0.001). Differential phage composition between lesional skin in patients with psoriasis and healthy skin from contralateral non-lesional sites and family controls, as well as the suppression of bacteria host of the respective phage, suggest possible avenues for probiotic phage therapeutics.
Persistent Identifierhttp://hdl.handle.net/10722/276130
ISSN
2017 Impact Factor: 6.448
2015 SCImago Journal Rankings: 2.612

 

DC FieldValueLanguage
dc.contributor.authorWang, H-
dc.contributor.authorChan, HH-
dc.contributor.authorNi, MY-
dc.contributor.authorLam, WW-
dc.contributor.authorChan, WMM-
dc.contributor.authorPang, H-
dc.date.accessioned2019-09-10T02:56:34Z-
dc.date.available2019-09-10T02:56:34Z-
dc.date.issued2019-
dc.identifier.citationThe Journal of Investigative Dermatology, 2019-
dc.identifier.issn0022-202X-
dc.identifier.urihttp://hdl.handle.net/10722/276130-
dc.description.abstractThe bacteriophage (phage) component of the skin microbiome in patients with psoriasis has not been systematically explored. The purpose of this study is to investigate phage and bacterial components of the skin microbiome in patients with psoriasis and in healthy family controls. Lesional skin swabs of four different locations (elbow, forearm, knee, and scalp) were taken from patients with psoriasis. Healthy skin swabs of matched locations were taken from contralateral non-lesional skin and healthy family controls. Skin microbiomes were investigated using next-generation shotgun metagenomics sequencing. 81 skin microbiome samples (27 lesional skin samples and 54 healthy skin samples from contralateral non-lesional skin and family controls) obtained from 16 subjects with psoriasis and 16 matched family controls were sequenced and analyzed. Among phage species with abundant host bacteria, two significantly differential abundant phage species, Acinetobacter phage Presley and Pseudomonas phage O4 (adjusted P < 0.05), between psoriasis lesional skin and healthy skin were identified. Samples with high levels of these phage species had their host bacteria abundance suppressed (P = 0.03 and P < 0.001). Differential phage composition between lesional skin in patients with psoriasis and healthy skin from contralateral non-lesional sites and family controls, as well as the suppression of bacteria host of the respective phage, suggest possible avenues for probiotic phage therapeutics.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at https://www.journals.elsevier.com/journal-of-investigative-dermatology-
dc.relation.ispartofThe Journal of Investigative Dermatology-
dc.titleBacteriophage of the Skin Microbiome in Patients with Psoriasis and Healthy Family Controls-
dc.typeArticle-
dc.identifier.emailChan, HH: hhlchan@hkucc.hku.hk-
dc.identifier.emailNi, MY: nimy@hku.hk-
dc.identifier.emailLam, WW: wwtlam@hku.hk-
dc.identifier.emailChan, WMM: chanwmm@hku.hk-
dc.identifier.emailPang, H: herbpang@hku.hk-
dc.identifier.authorityNi, MY=rp01639-
dc.identifier.authorityLam, WW=rp00443-
dc.identifier.authorityChan, WMM=rp02394-
dc.identifier.authorityPang, H=rp01857-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jid.2019.05.023-
dc.identifier.pmid31247199-
dc.identifier.scopuseid_2-s2.0-85072782207-
dc.identifier.hkuros302390-
dc.publisher.placeUnited Kingdom-

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