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- Publisher Website: 10.1007/s12094-018-1914-4
- Scopus: eid_2-s2.0-85049775009
- PMID: 30003531
- WOS: WOS:000457562500003
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Article: Molecular biomarkers for prognosis of gastrointestinal stromal tumor.
Title | Molecular biomarkers for prognosis of gastrointestinal stromal tumor. |
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Authors | |
Keywords | DNA markers GIST KIT miRNA markers PDGFRA Prognosis |
Issue Date | 2018 |
Publisher | Ediciones Doyma SA. |
Citation | Clinical and Translational Oncology, 2018, v. 21 n. 2, p. 145-151 How to Cite? |
Abstract | Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. However, the development of molecular markers, especially circulating biomarkers, remains largely undone for the prognosis of GIST. We discussed the clinical-pathological characteristics of GIST and identified potential biomarkers for guidance of therapy and prognosis of GIST. Around 90% of GISTs contain mutations in KIT or PDGFRA and the remaining 10% of GISTs are wild-type. Recent studies have indicated that various DNAs and miRNAs could serve as potential biomarkers for prognosis of GIST, including KIT, PDGFRA, other DNAs (such as BRAF, SDH, SETD2 and ROR2), and microRNAs (miRNAs). The pressing need and challenges in the development of circulating prognostic biomarkers for GIST are also discussed. Although challenges remain, DNAs and miRNAs are promising circulating biomarkers for surveillance and prognosis of GIST. Advances in clarification of aberrant molecular alterations may open new avenues for exploration of reliable and robust biomarkers to improve the management of GIST. © 2018, Federación de Sociedades Españolas de Oncología (FESEO). |
Persistent Identifier | http://hdl.handle.net/10722/275760 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.837 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, X | - |
dc.contributor.author | Chu, KM | - |
dc.date.accessioned | 2019-09-10T02:49:08Z | - |
dc.date.available | 2019-09-10T02:49:08Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Clinical and Translational Oncology, 2018, v. 21 n. 2, p. 145-151 | - |
dc.identifier.issn | 1699-048X | - |
dc.identifier.uri | http://hdl.handle.net/10722/275760 | - |
dc.description.abstract | Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. However, the development of molecular markers, especially circulating biomarkers, remains largely undone for the prognosis of GIST. We discussed the clinical-pathological characteristics of GIST and identified potential biomarkers for guidance of therapy and prognosis of GIST. Around 90% of GISTs contain mutations in KIT or PDGFRA and the remaining 10% of GISTs are wild-type. Recent studies have indicated that various DNAs and miRNAs could serve as potential biomarkers for prognosis of GIST, including KIT, PDGFRA, other DNAs (such as BRAF, SDH, SETD2 and ROR2), and microRNAs (miRNAs). The pressing need and challenges in the development of circulating prognostic biomarkers for GIST are also discussed. Although challenges remain, DNAs and miRNAs are promising circulating biomarkers for surveillance and prognosis of GIST. Advances in clarification of aberrant molecular alterations may open new avenues for exploration of reliable and robust biomarkers to improve the management of GIST. © 2018, Federación de Sociedades Españolas de Oncología (FESEO). | - |
dc.language | eng | - |
dc.publisher | Ediciones Doyma SA. | - |
dc.relation.ispartof | Clinical and Translational Oncology | - |
dc.subject | DNA markers | - |
dc.subject | GIST | - |
dc.subject | KIT | - |
dc.subject | miRNA markers | - |
dc.subject | PDGFRA | - |
dc.subject | Prognosis | - |
dc.title | Molecular biomarkers for prognosis of gastrointestinal stromal tumor. | - |
dc.type | Article | - |
dc.identifier.email | Liu, X: melx1301@hku.hk | - |
dc.identifier.email | Chu, KM: chukm@hku.hk | - |
dc.identifier.authority | Chu, KM=rp00435 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s12094-018-1914-4 | - |
dc.identifier.pmid | 30003531 | - |
dc.identifier.scopus | eid_2-s2.0-85049775009 | - |
dc.identifier.hkuros | 304715 | - |
dc.identifier.volume | 21 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 145 | - |
dc.identifier.epage | 151 | - |
dc.identifier.isi | WOS:000457562500003 | - |
dc.publisher.place | Spain | - |
dc.identifier.issnl | 1699-048X | - |