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- PMID: 31285759
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Article: Third-line Systemic Treatment In Advanced/metastatic Gastric Cancer: A Comprehensive Review
Title | Third-line Systemic Treatment In Advanced/metastatic Gastric Cancer: A Comprehensive Review |
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Authors | |
Keywords | gastric cancer immunotherapy metastatic palliative systemic treatment |
Issue Date | 2019 |
Publisher | Sage Publications Ltd.. The Journal's web site is located at http://tag.sagepub.com |
Citation | Therapeutic Advances in Gastroenterology, 2019, v. 11, p. 1-11 How to Cite? |
Abstract | The management of advanced gastric cancer has improved over the past decade. There is more evidence to support the efficacy of systemic treatment in refractory gastric cancer beyond second-line treatment. Important randomized controlled trials of chemotherapies, targeted agents and immunotherapies have been reported. With the development of these novel therapies, clinicians can better individualize treatment for patients beyond progression on second-line therapy. However, there is no guideline on third-line therapy available for clinicians. This review discussed the efficacy and safety data from the pivotal trials of the agents proven to be effective in third-line settings, including the quality of study design, level of evidence and subgroup analysis, and how the data can help to guide clinicians on selecting the most appropriate third-line therapy for their patients. |
Persistent Identifier | http://hdl.handle.net/10722/275709 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.189 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lam, KO | - |
dc.contributor.author | Chan, WLW | - |
dc.contributor.author | So, TH | - |
dc.contributor.author | Lee, VHF | - |
dc.contributor.author | Kwong, DLW | - |
dc.date.accessioned | 2019-09-10T02:48:04Z | - |
dc.date.available | 2019-09-10T02:48:04Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Therapeutic Advances in Gastroenterology, 2019, v. 11, p. 1-11 | - |
dc.identifier.issn | 1756-283X | - |
dc.identifier.uri | http://hdl.handle.net/10722/275709 | - |
dc.description.abstract | The management of advanced gastric cancer has improved over the past decade. There is more evidence to support the efficacy of systemic treatment in refractory gastric cancer beyond second-line treatment. Important randomized controlled trials of chemotherapies, targeted agents and immunotherapies have been reported. With the development of these novel therapies, clinicians can better individualize treatment for patients beyond progression on second-line therapy. However, there is no guideline on third-line therapy available for clinicians. This review discussed the efficacy and safety data from the pivotal trials of the agents proven to be effective in third-line settings, including the quality of study design, level of evidence and subgroup analysis, and how the data can help to guide clinicians on selecting the most appropriate third-line therapy for their patients. | - |
dc.language | eng | - |
dc.publisher | Sage Publications Ltd.. The Journal's web site is located at http://tag.sagepub.com | - |
dc.relation.ispartof | Therapeutic Advances in Gastroenterology | - |
dc.rights | Therapeutic Advances in Gastroenterology. Copyright © Sage Publications Ltd.. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | gastric cancer | - |
dc.subject | immunotherapy | - |
dc.subject | metastatic | - |
dc.subject | palliative | - |
dc.subject | systemic treatment | - |
dc.title | Third-line Systemic Treatment In Advanced/metastatic Gastric Cancer: A Comprehensive Review | - |
dc.type | Article | - |
dc.identifier.email | Lam, KO: lamkaon@hku.hk | - |
dc.identifier.email | Chan, WLW: winglok@hku.hk | - |
dc.identifier.email | So, TH: sth495@hku.hk | - |
dc.identifier.email | Lee, VHF: vhflee@hku.hk | - |
dc.identifier.email | Kwong, DLW: dlwkwong@hku.hk | - |
dc.identifier.authority | Lam, KO=rp01501 | - |
dc.identifier.authority | Chan, WLW=rp02541 | - |
dc.identifier.authority | So, TH=rp01981 | - |
dc.identifier.authority | Lee, VHF=rp00264 | - |
dc.identifier.authority | Kwong, DLW=rp00414 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1177/1758835919859990 | - |
dc.identifier.pmid | 31285759 | - |
dc.identifier.scopus | eid_2-s2.0-85068404537 | - |
dc.identifier.hkuros | 302926 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 11 | - |
dc.identifier.isi | WOS:000478865000001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1756-283X | - |