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Article: Broadleaf Mahonia Attenuates Granulomatous Lobular Mastitis-Associated Inflammation by Inhibiting CCL-5 Expression in Macrophages

TitleBroadleaf Mahonia Attenuates Granulomatous Lobular Mastitis-Associated Inflammation by Inhibiting CCL-5 Expression in Macrophages
Authors
Issue Date2018
PublisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijmm/
Citation
International Journal of Molecular Medicine, 2018, v. 41 n. 1, p. 340-352 How to Cite?
AbstractGranulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requirement that safe and efficient natural drugs are found to improve the GLM prognosis. Broadleaf Mahonia (BM) is a traditional Chinese herb that is believed to have anti‑inflammatory properties according to ancient records of traditional Chinese medicine. The present study investigated this belief and demonstrated that BM significantly inhibited the expression of interleukin‑1β (IL‑1β), IL‑6, cyclooxygenase‑2 and inducible nitric oxide synthase in RAW264.7 cells, but had little influence on the cell viability, cell cycle and apoptosis. Meanwhile, the lipopolysaccharide‑induced elevation of reactive oxygen species and nitric oxide was also blocked following BM treatment, accompanied with decreased activity of nuclear factor‑κB and MAPK signaling. A cytokine array further validated that BM exhibited significant inhibitory effects on several chemoattractants, including chemokine (C‑C motif) ligand (CCL)‑2, CCL‑3, CCL‑5 and secreted tumor necrosis factor receptor 1, among which CCL‑5 exhibited the highest inhibition ratio in cell and clinical GLM specimens. Collectively, the results show that BM is a novel effective anti‑inflammatory herb in vitro and ex vivo, and that CCL‑5 may be closely associated with GLM pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/275456
ISSN
2017 Impact Factor: 2.784
2015 SCImago Journal Rankings: 0.868
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorWANG, Z-
dc.contributor.authorWANG, N-
dc.contributor.authorLiu, X-
dc.contributor.authorWang, Q-
dc.contributor.authorXie, B-
dc.contributor.authorLIu, P-
dc.contributor.authorZhu, H-
dc.contributor.authorChen, J-
dc.contributor.authorSitu, H-
dc.contributor.authorLIN, Y-
dc.date.accessioned2019-09-10T02:42:56Z-
dc.date.available2019-09-10T02:42:56Z-
dc.date.issued2018-
dc.identifier.citationInternational Journal of Molecular Medicine, 2018, v. 41 n. 1, p. 340-352-
dc.identifier.issn1107-3756-
dc.identifier.urihttp://hdl.handle.net/10722/275456-
dc.description.abstractGranulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requirement that safe and efficient natural drugs are found to improve the GLM prognosis. Broadleaf Mahonia (BM) is a traditional Chinese herb that is believed to have anti‑inflammatory properties according to ancient records of traditional Chinese medicine. The present study investigated this belief and demonstrated that BM significantly inhibited the expression of interleukin‑1β (IL‑1β), IL‑6, cyclooxygenase‑2 and inducible nitric oxide synthase in RAW264.7 cells, but had little influence on the cell viability, cell cycle and apoptosis. Meanwhile, the lipopolysaccharide‑induced elevation of reactive oxygen species and nitric oxide was also blocked following BM treatment, accompanied with decreased activity of nuclear factor‑κB and MAPK signaling. A cytokine array further validated that BM exhibited significant inhibitory effects on several chemoattractants, including chemokine (C‑C motif) ligand (CCL)‑2, CCL‑3, CCL‑5 and secreted tumor necrosis factor receptor 1, among which CCL‑5 exhibited the highest inhibition ratio in cell and clinical GLM specimens. Collectively, the results show that BM is a novel effective anti‑inflammatory herb in vitro and ex vivo, and that CCL‑5 may be closely associated with GLM pathogenesis.-
dc.languageeng-
dc.publisherSpandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijmm/-
dc.relation.ispartofInternational Journal of Molecular Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleBroadleaf Mahonia Attenuates Granulomatous Lobular Mastitis-Associated Inflammation by Inhibiting CCL-5 Expression in Macrophages-
dc.typeArticle-
dc.identifier.emailChen, J: abchen@hkucc.hku.hk-
dc.identifier.authorityChen, J=rp01316-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3892/ijmm.2017.3246-
dc.identifier.pmid29138800-
dc.identifier.pmcidPMC5746325-
dc.identifier.scopuseid_2-s2.0-85049541734-
dc.identifier.hkuros305033-
dc.identifier.volume41-
dc.identifier.issue1-
dc.identifier.spage340-
dc.identifier.epage352-
dc.publisher.placeGreece-

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