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Conference Paper: The prognostic stratification using acute-on-chronic liver failure scoring system for predicting short-term mortality in patients with alcoholic hepatitis

TitleThe prognostic stratification using acute-on-chronic liver failure scoring system for predicting short-term mortality in patients with alcoholic hepatitis
Authors
Issue Date2018
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
The Liver Meeting 2018, American Association for the Study of Liver Diseases (AASLD), San Francisco, USA, 9-13 November 2018. Abstracts in Hepatology, 2018, v. 68 n. Suppl. 1, p. 807A-808A How to Cite?
AbstractBackground: To compare the existing various prognostic scoring models and newly proposed scores for acuteon-chronic liver failure (ACLF) and evaluate usefulness of stratification for the prediction of short-term morality in patients with alcoholic hepatitis (AH). Methods: A total of 705 clinical AH patients, enrolled in the APASL-ACLF Research Consortium (AARC) with 90-day follow-up, were analyzed. AARC-ACLF score, Maddrey discrimination function (DF) score, age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), Child-Turcott-Pugh (CTP) score, model for endstage liver disease (MELD), and MELD-Sodium (Na) scores were used to compare the performance for predicting 30-day and 90-day mortality. AARC-ACLF scores were categorized into three grades (Gr I: 5-7; II: 8-10; and III: 11-15 points) and survival curves by the Kaplan-Meier method were created and compared using log-rank test. Results: Of 708 patients, 286 (40.4%) and 363 (51.3%) patients died within 30 days and 90 days, respectively. The area under receiver operating characteristics curve (AUC) of AARC-ACLF, DF, ABIC, GAHS, CTP, MELD, and MELD-Na was 0.752 (0.705-0.799), 0.630 (0.575-0.685), 0.658 (0.604-0.711), 0.577 (0.523-0.631), 0.641 (0.589-0.694), 0.705 (0.653-0.756), 0.703 (0.651- 0.755), respectively, for 30-day mortality. The AUC of various prognostic scores for the prediction of 90-day mortality is similar. The performance of AARC-ACLF was superior to that of DF, ABIC, GAHS, CTP, while comparable to that of MELD and MELD-Na in predicting short-term mortality. According to AARC-ACLF grades, short-term cumulative survivals was statistically different (30-day, 82.4, 70.4, and 35.3%, p <0.001; 90-day, 76.9, 56.0, and 26.4%, p <0.001). Conclusion: Compared to the previous AH prognostic scores, AARCACLF score and grades are simple and useful for predicting the short-term mortality in patients with AH. Further studies are needed to confirm these implications.
DescriptionPoster Presentation - no. 1407
Persistent Identifierhttp://hdl.handle.net/10722/275338
ISSN
2017 Impact Factor: 14.079
2015 SCImago Journal Rankings: 4.752

 

DC FieldValueLanguage
dc.contributor.authorSong, DS-
dc.contributor.authorKim, DJ-
dc.contributor.authorJia, JD-
dc.contributor.authorChoudhury, AK-
dc.contributor.authorMahtab, MA-
dc.contributor.authorDevarbhavi, H-
dc.contributor.authorDuan, Z-
dc.contributor.authorChen, Y-
dc.contributor.authorEapen, CE-
dc.contributor.authorGoel, A-
dc.contributor.authorQing, Q-
dc.contributor.authorMa, K-
dc.contributor.authorChawla, YK-
dc.contributor.authorDhiman, RK-
dc.contributor.authorDuseja, AK-
dc.contributor.authorTaneja, S-
dc.contributor.authorHamid, SS-
dc.contributor.authorButt, AS-
dc.contributor.authorJafri, SMW-
dc.contributor.authorTan, SS-
dc.contributor.authorGhazinian, H-
dc.contributor.authorAmarapurkar, DN-
dc.contributor.authorTreeprasertsuk, S-
dc.contributor.authorLee, GH-
dc.contributor.authorLim, SG-
dc.contributor.authorHu, J-
dc.contributor.authorLesmana, LA-
dc.contributor.authorLesmana, CR-
dc.contributor.authorShukla, A-
dc.contributor.authorShah, S-
dc.contributor.authorKalal, CR-
dc.contributor.authorSahu, M-
dc.contributor.authorAbbas, Z-
dc.contributor.authorSollano, JD-
dc.contributor.authorCarpio, G-
dc.contributor.authorKarim, F-
dc.contributor.authorLau, GKK-
dc.contributor.authorRao, PN-
dc.contributor.authorPayawal, DA-
dc.contributor.authorDokmeci, A-
dc.contributor.authorYuen, RMF-
dc.contributor.authorPrasad, VGM-
dc.contributor.authorYokosuka, O-
dc.contributor.authorShrestha, A-
dc.contributor.authorJain, P-
dc.contributor.authorPaulson, I-
dc.contributor.authorSarin, SK-
dc.date.accessioned2019-09-10T02:40:34Z-
dc.date.available2019-09-10T02:40:34Z-
dc.date.issued2018-
dc.identifier.citationThe Liver Meeting 2018, American Association for the Study of Liver Diseases (AASLD), San Francisco, USA, 9-13 November 2018. Abstracts in Hepatology, 2018, v. 68 n. Suppl. 1, p. 807A-808A-
dc.identifier.issn0270-9139-
dc.identifier.urihttp://hdl.handle.net/10722/275338-
dc.descriptionPoster Presentation - no. 1407-
dc.description.abstractBackground: To compare the existing various prognostic scoring models and newly proposed scores for acuteon-chronic liver failure (ACLF) and evaluate usefulness of stratification for the prediction of short-term morality in patients with alcoholic hepatitis (AH). Methods: A total of 705 clinical AH patients, enrolled in the APASL-ACLF Research Consortium (AARC) with 90-day follow-up, were analyzed. AARC-ACLF score, Maddrey discrimination function (DF) score, age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), Child-Turcott-Pugh (CTP) score, model for endstage liver disease (MELD), and MELD-Sodium (Na) scores were used to compare the performance for predicting 30-day and 90-day mortality. AARC-ACLF scores were categorized into three grades (Gr I: 5-7; II: 8-10; and III: 11-15 points) and survival curves by the Kaplan-Meier method were created and compared using log-rank test. Results: Of 708 patients, 286 (40.4%) and 363 (51.3%) patients died within 30 days and 90 days, respectively. The area under receiver operating characteristics curve (AUC) of AARC-ACLF, DF, ABIC, GAHS, CTP, MELD, and MELD-Na was 0.752 (0.705-0.799), 0.630 (0.575-0.685), 0.658 (0.604-0.711), 0.577 (0.523-0.631), 0.641 (0.589-0.694), 0.705 (0.653-0.756), 0.703 (0.651- 0.755), respectively, for 30-day mortality. The AUC of various prognostic scores for the prediction of 90-day mortality is similar. The performance of AARC-ACLF was superior to that of DF, ABIC, GAHS, CTP, while comparable to that of MELD and MELD-Na in predicting short-term mortality. According to AARC-ACLF grades, short-term cumulative survivals was statistically different (30-day, 82.4, 70.4, and 35.3%, p <0.001; 90-day, 76.9, 56.0, and 26.4%, p <0.001). Conclusion: Compared to the previous AH prognostic scores, AARCACLF score and grades are simple and useful for predicting the short-term mortality in patients with AH. Further studies are needed to confirm these implications.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/-
dc.relation.ispartofHepatology-
dc.relation.ispartofAmerican Association for the Study of Liver Diseases (AASLD): The Liver Meeting 2018-
dc.titleThe prognostic stratification using acute-on-chronic liver failure scoring system for predicting short-term mortality in patients with alcoholic hepatitis-
dc.typeConference_Paper-
dc.identifier.emailYuen, RMF: mfyuen@hku.hk-
dc.identifier.authorityYuen, RMF=rp00479-
dc.identifier.hkuros304617-
dc.identifier.volume68-
dc.identifier.issueSuppl. 1-
dc.identifier.spage807A-
dc.identifier.epage808A-
dc.publisher.placeUnited States-

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