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Article: The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice

TitleThe histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice
Authors
KeywordsCell divisions
DNA double strand breaks
Genetic diversity
Histone modification
Homologous recombination
Issue Date2019
PublisherAmerican Association for the Advancement of Science: Science Advances. The Journal's web site is located at http://www.scienceadvances.org/
Citation
Science Advances, 2019, v. 5 n. 8, p. article no. eaax1101 How to Cite?
AbstractMeiosis is a specialized type of cell division that creates haploid germ cells and ensures their genetic diversity through homologous recombination. We show that the H3K4me3 reader ZCWPW1 is specifically required for meiosis prophase I progression in male but not in female germ cells in mice. Loss of Zcwpw1 in male mice caused a complete failure of synapsis, resulting in meiotic arrest at the zygotene to pachytene stage, accompanied by incomplete DNA double-strand break repair and lack of crossover formation, leading to male infertility. In oocytes, deletion of Zcwpw1 only somewhat slowed down meiosis prophase I progression; Zcwpw1−/− oocytes were able to complete meiosis, and Zcwpw1−/− female mice had normal fertility until mid-adulthood. We conclude that the H3K4me3 reader ZCWPW1 is indispensable for meiosis synapsis in males but is dispensable for females. Our results suggest that ZCWPW1 may represent a previously unknown, sex-dependent epigenetic regulator of germ cell meiosis in mammals.
Persistent Identifierhttp://hdl.handle.net/10722/275187
ISSN
2017 Impact Factor: 11.511
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLi, M-
dc.contributor.authorHuang, T-
dc.contributor.authorLi, MJ-
dc.contributor.authorZhang, CX-
dc.contributor.authorYu, XC-
dc.contributor.authorYin, YY-
dc.contributor.authorLiu, C-
dc.contributor.authorWang, X-
dc.contributor.authorFeng, HW-
dc.contributor.authorZhang, T-
dc.contributor.authorLiu, MF-
dc.contributor.authorHan, CS-
dc.contributor.authorLu, G-
dc.contributor.authorLi, W-
dc.contributor.authorMa, JL-
dc.contributor.authorChen, ZJ-
dc.contributor.authorLiu, HB-
dc.contributor.authorLiu, K-
dc.date.accessioned2019-09-10T02:37:22Z-
dc.date.available2019-09-10T02:37:22Z-
dc.date.issued2019-
dc.identifier.citationScience Advances, 2019, v. 5 n. 8, p. article no. eaax1101-
dc.identifier.issn2375-2548-
dc.identifier.urihttp://hdl.handle.net/10722/275187-
dc.description.abstractMeiosis is a specialized type of cell division that creates haploid germ cells and ensures their genetic diversity through homologous recombination. We show that the H3K4me3 reader ZCWPW1 is specifically required for meiosis prophase I progression in male but not in female germ cells in mice. Loss of Zcwpw1 in male mice caused a complete failure of synapsis, resulting in meiotic arrest at the zygotene to pachytene stage, accompanied by incomplete DNA double-strand break repair and lack of crossover formation, leading to male infertility. In oocytes, deletion of Zcwpw1 only somewhat slowed down meiosis prophase I progression; Zcwpw1−/− oocytes were able to complete meiosis, and Zcwpw1−/− female mice had normal fertility until mid-adulthood. We conclude that the H3K4me3 reader ZCWPW1 is indispensable for meiosis synapsis in males but is dispensable for females. Our results suggest that ZCWPW1 may represent a previously unknown, sex-dependent epigenetic regulator of germ cell meiosis in mammals.-
dc.languageeng-
dc.publisherAmerican Association for the Advancement of Science: Science Advances. The Journal's web site is located at http://www.scienceadvances.org/-
dc.relation.ispartofScience Advances-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCell divisions-
dc.subjectDNA double strand breaks-
dc.subjectGenetic diversity-
dc.subjectHistone modification-
dc.subjectHomologous recombination-
dc.titleThe histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice-
dc.typeArticle-
dc.identifier.emailLi, M: miaoli@HKUCC-COM.hku.hk-
dc.identifier.emailLiu, K: kliugc@hku.hk-
dc.identifier.authorityLiu, K=rp02475-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1126/sciadv.aax1101-
dc.identifier.pmid31453335-
dc.identifier.pmcidPMC6693912-
dc.identifier.scopuseid_2-s2.0-85070936073-
dc.identifier.hkuros305011-
dc.identifier.volume5-
dc.identifier.issue8-
dc.identifier.spagearticle no. eaax1101-
dc.identifier.epagearticle no. eaax1101-
dc.publisher.placeUnited States-

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