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Article: The applications of metabolomics in the molecular diagnostics of cancer

TitleThe applications of metabolomics in the molecular diagnostics of cancer
Authors
Keywordscancer
metabolite profiling
metabolomics
molecular diagnostics
MS
Issue Date2019
PublisherTaylor & Francis. The Journal's web site is located at http://www.tandfonline.com/loi/iero20#.VgGYxUaFOnI
Citation
Expert Review of Molecular Diagnostics, 2019, v. 19 n. 9, p. 785-793 How to Cite?
AbstractIntroduction: Metabolomics, the study of metabolites, is a promising research field for cancers. The metabolic pathway in a tumor cell is different from a normal tissue cell. There are two approaches to study the metabolism, targeted and untargeted. The general approach is that metabolomic data are interpreted by bioinformatics tools correlating with metabolomic databases to obtain significant findings. With the use of specific analysis tools, such as nuclear magnetic resonance (NMR) and mass spectrometer (MS) combined with chromatography, metabolic profile or metabolic fingerprint of various biological specimens could be obtained. The applications of metabolomics are used to discover potential cancer biomarkers and monitor the metastatic state, therapeutic and drug response for better patient management. Areas covered: In this review, the author introduce metabolomics and discuss the use of metabolomics approaches in different cancers, including the study of colorectal cancer, prostate cancer, liver cancer, pancreatic cancer and breast cancer using NMR and MS. Expert opinion: Knowledge on the molecular basis of cancer metabolism and its potential clinical applications has been improving recently. However, there are still many challenges for the technological development and integration of metabolomics with other omics spaces such as genomics. In the near future, it is expected that metabolomics will play an important role in cancer molecular diagnostics. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Persistent Identifierhttp://hdl.handle.net/10722/275116
ISSN
2017 Impact Factor: 3.326
2015 SCImago Journal Rankings: 0.942

 

DC FieldValueLanguage
dc.contributor.authorCheung, PK-
dc.contributor.authorMa, MH-
dc.contributor.authorTse, HF-
dc.contributor.authorYeung, HF-
dc.contributor.authorChu, MKM-
dc.contributor.authorKan, CM-
dc.contributor.authorCho, WCS-
dc.contributor.authorNg, LBW-
dc.contributor.authorChan, LWC-
dc.contributor.authorWong, SCC-
dc.date.accessioned2019-09-10T02:35:46Z-
dc.date.available2019-09-10T02:35:46Z-
dc.date.issued2019-
dc.identifier.citationExpert Review of Molecular Diagnostics, 2019, v. 19 n. 9, p. 785-793-
dc.identifier.issn1473-7159-
dc.identifier.urihttp://hdl.handle.net/10722/275116-
dc.description.abstractIntroduction: Metabolomics, the study of metabolites, is a promising research field for cancers. The metabolic pathway in a tumor cell is different from a normal tissue cell. There are two approaches to study the metabolism, targeted and untargeted. The general approach is that metabolomic data are interpreted by bioinformatics tools correlating with metabolomic databases to obtain significant findings. With the use of specific analysis tools, such as nuclear magnetic resonance (NMR) and mass spectrometer (MS) combined with chromatography, metabolic profile or metabolic fingerprint of various biological specimens could be obtained. The applications of metabolomics are used to discover potential cancer biomarkers and monitor the metastatic state, therapeutic and drug response for better patient management. Areas covered: In this review, the author introduce metabolomics and discuss the use of metabolomics approaches in different cancers, including the study of colorectal cancer, prostate cancer, liver cancer, pancreatic cancer and breast cancer using NMR and MS. Expert opinion: Knowledge on the molecular basis of cancer metabolism and its potential clinical applications has been improving recently. However, there are still many challenges for the technological development and integration of metabolomics with other omics spaces such as genomics. In the near future, it is expected that metabolomics will play an important role in cancer molecular diagnostics. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.-
dc.languageeng-
dc.publisherTaylor & Francis. The Journal's web site is located at http://www.tandfonline.com/loi/iero20#.VgGYxUaFOnI-
dc.relation.ispartofExpert Review of Molecular Diagnostics-
dc.rightsAOM/Preprint Before Accepted: his article has been accepted for publication in [JOURNAL TITLE], published by Taylor & Francis. AOM/Preprint After Accepted: This is an [original manuscript / preprint] of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI]. Accepted Manuscript (AM) i.e. Postprint This is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI].-
dc.subjectcancer-
dc.subjectmetabolite profiling-
dc.subjectmetabolomics-
dc.subjectmolecular diagnostics-
dc.subjectMS-
dc.titleThe applications of metabolomics in the molecular diagnostics of cancer-
dc.typeArticle-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityTse, HF=rp00428-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/14737159.2019.1656530-
dc.identifier.scopuseid_2-s2.0-85070994160-
dc.identifier.hkuros304616-
dc.identifier.volume19-
dc.identifier.issue9-
dc.identifier.spage785-
dc.identifier.epage793-
dc.publisher.placeUnited Kingdom-

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