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Article: ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis

TitleASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis
Authors
KeywordsSpondyloarthritis Research Consortium of Canada MRI
ankylosing spondylitis disease activity index
diffusion-weighted imaging
inflammation
short tau inversion recovery sequence
Issue Date2019
PublisherBMJ Publishing Group: Open Access. The Journal's web site is located at http://rmdopen.bmj.com/
Citation
RMD Open, 2019, v. 5 n. 2, p. article no. e001008 How to Cite?
AbstractObjective: To investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA). Methods: Participants with axial SpA and back pain were recruited. Clinical, demographic, biochemical and imaging data were collected. ASDAS was calculated based on C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Inflammatory lesions were identified in short tau inversion recovery images and the corresponding ADC maps to determine the maximum apparent diffusion coefficient (ADCmax), normalised maximum ADC, mean apparent diffusion coefficient (ADCmean) and normalised mean ADC by two independent readers. Spondyloarthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint MRI indexes were determined. Univariate and multivariate linear regression models were used to determine the associations between of ASDAS with ADC values, SPARCC spine and SI MRI scores. Results: Eighty-two participants had identifiable ADC lesions. Multivariate analyses using ADCmax and SPARCC spine MRI as independent variables showed associations with ASDAS-CRP (ADCmax: B=0.27, p=0.02; SPARCC: B=0.32, p=0.01) and ASDAS-ESR (ADCmax: B=0.24, p=0.03; SPARCC: B=0.36, p<0.01); using ADCmean and SPARCC spine MRI as independent variables also showed an association with ASDAS-ESR (ADCmean: B=0.22, p=0.05; SPARCC: B=0.36, p<0.01) and a tendency to associate with ASDAS-CRP (ADCmean: B=0.21, p=0.07; SPARCC: B=0.34, p<0.01). Conclusion: ASDAS is associated with both the extent and the intensity of spinal inflammation in patients with detectable inflammatory lesions. Our results showed that ASDAS is an objective disease assessment tool. Trial registration number: HKUCTR-2087.
Persistent Identifierhttp://hdl.handle.net/10722/275115
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorChung, HY-
dc.contributor.authorChui, ETF-
dc.contributor.authorLee, KH-
dc.contributor.authorTsang, HHL-
dc.contributor.authorChan, SCW-
dc.contributor.authorLau, CS-
dc.date.accessioned2019-09-10T02:35:45Z-
dc.date.available2019-09-10T02:35:45Z-
dc.date.issued2019-
dc.identifier.citationRMD Open, 2019, v. 5 n. 2, p. article no. e001008-
dc.identifier.issn2056-5933-
dc.identifier.urihttp://hdl.handle.net/10722/275115-
dc.description.abstractObjective: To investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA). Methods: Participants with axial SpA and back pain were recruited. Clinical, demographic, biochemical and imaging data were collected. ASDAS was calculated based on C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Inflammatory lesions were identified in short tau inversion recovery images and the corresponding ADC maps to determine the maximum apparent diffusion coefficient (ADCmax), normalised maximum ADC, mean apparent diffusion coefficient (ADCmean) and normalised mean ADC by two independent readers. Spondyloarthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint MRI indexes were determined. Univariate and multivariate linear regression models were used to determine the associations between of ASDAS with ADC values, SPARCC spine and SI MRI scores. Results: Eighty-two participants had identifiable ADC lesions. Multivariate analyses using ADCmax and SPARCC spine MRI as independent variables showed associations with ASDAS-CRP (ADCmax: B=0.27, p=0.02; SPARCC: B=0.32, p=0.01) and ASDAS-ESR (ADCmax: B=0.24, p=0.03; SPARCC: B=0.36, p<0.01); using ADCmean and SPARCC spine MRI as independent variables also showed an association with ASDAS-ESR (ADCmean: B=0.22, p=0.05; SPARCC: B=0.36, p<0.01) and a tendency to associate with ASDAS-CRP (ADCmean: B=0.21, p=0.07; SPARCC: B=0.34, p<0.01). Conclusion: ASDAS is associated with both the extent and the intensity of spinal inflammation in patients with detectable inflammatory lesions. Our results showed that ASDAS is an objective disease assessment tool. Trial registration number: HKUCTR-2087.-
dc.languageeng-
dc.publisherBMJ Publishing Group: Open Access. The Journal's web site is located at http://rmdopen.bmj.com/-
dc.relation.ispartofRMD Open-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectSpondyloarthritis Research Consortium of Canada MRI-
dc.subjectankylosing spondylitis disease activity index-
dc.subjectdiffusion-weighted imaging-
dc.subjectinflammation-
dc.subjectshort tau inversion recovery sequence-
dc.titleASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis-
dc.typeArticle-
dc.identifier.emailChung, HY: jameschy@hku.hk-
dc.identifier.emailLau, CS: cslau@hku.hk-
dc.identifier.authorityChung, HY=rp02330-
dc.identifier.authorityLau, CS=rp01348-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/rmdopen-2019-001008-
dc.identifier.pmid31452930-
dc.identifier.pmcidPMC6691514-
dc.identifier.scopuseid_2-s2.0-85070372776-
dc.identifier.hkuros304587-
dc.identifier.volume5-
dc.identifier.issue2-
dc.identifier.spagearticle no. e001008-
dc.identifier.epagearticle no. e001008-
dc.publisher.placeUnited Kingdom-

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