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Article: Solid liver tumours with cystic appearance: do they have the same outcome?

TitleSolid liver tumours with cystic appearance: do they have the same outcome?
Authors
KeywordsChildren
Embryonal sarcoma
Liver tumour
Mesenchymal hamartoma
Issue Date2019
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal of Paediatrics (New series), 2019, v. 24 n. 2, p. 70-75 How to Cite?
AbstractObjective: Paediatric undifferentiated embryonal sarcoma (UES) and mesenchymal hamartoma (MH) of liver have similar imaging cystic imaging characteristic but have totally different clinical behaviour. We reviewed ours experience and compared that with the literature. Methods: Our patients' database over the past 25 years and all articles available from PubMed up to December 2016 were searched. Case reports recorded with demographic data, clinical information and investigations were recruited. The diagnosis of all cases had to be confirmed by histopathology. The data was analysed by SPSS 11.0 software. Results: We identified 2 cases each of UES and MH in our centre, and from the literature, there were a total of 219 cases of UES and 138 cases of MH. The age at diagnosis for UES ranged from 1-83 years but 39.73% were between 6-10 years, whereas 65.22% of MH were found at <2 years (range, newborn-73 years). The chief complaint for UES was abdominal distension with or without abdominal pain and 50.81% of them had accompanied systemic symptoms. In contrary, only 9.57% of MH had systemic symptoms. Interestingly, both tumours were more commonly found in the right hepatic lobe. The prognosis of these two entities was quite different, 41/103 (39.81%) of UES died, whereas only 7/110 (6.36%) cases with MH died. UES required additional chemotherapy whereas MH did not. With the limited information, some authors suggested that the ultrasonography findings were better concordant with the histology than computed tomography or magnetic resonance imaging. 54.9% UES patients' tumour was solid and only 30.36% were cystic. For MH, there was no significant difference in the nature of tumour. Conclusion: Similar imaging appearance and possible pathological overlap between UES and MH makes the initial diagnosis difficult to be established. Surgical biopsy and excision remained mandatory to confirm the diagnosis and to guide the subsequent treatment option. © 2018, Medcom Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/274935
ISSN
2017 Impact Factor: 0.07
2015 SCImago Journal Rankings: 0.123

 

DC FieldValueLanguage
dc.contributor.authorYu, JL-
dc.contributor.authorKhong, PL-
dc.contributor.authorChiang, AKS-
dc.contributor.authorCheuk, KLD-
dc.contributor.authorHa, SY-
dc.contributor.authorChan, GCF-
dc.date.accessioned2019-09-10T02:31:55Z-
dc.date.available2019-09-10T02:31:55Z-
dc.date.issued2019-
dc.identifier.citationHong Kong Journal of Paediatrics (New series), 2019, v. 24 n. 2, p. 70-75-
dc.identifier.issn1013-9923-
dc.identifier.urihttp://hdl.handle.net/10722/274935-
dc.description.abstractObjective: Paediatric undifferentiated embryonal sarcoma (UES) and mesenchymal hamartoma (MH) of liver have similar imaging cystic imaging characteristic but have totally different clinical behaviour. We reviewed ours experience and compared that with the literature. Methods: Our patients' database over the past 25 years and all articles available from PubMed up to December 2016 were searched. Case reports recorded with demographic data, clinical information and investigations were recruited. The diagnosis of all cases had to be confirmed by histopathology. The data was analysed by SPSS 11.0 software. Results: We identified 2 cases each of UES and MH in our centre, and from the literature, there were a total of 219 cases of UES and 138 cases of MH. The age at diagnosis for UES ranged from 1-83 years but 39.73% were between 6-10 years, whereas 65.22% of MH were found at <2 years (range, newborn-73 years). The chief complaint for UES was abdominal distension with or without abdominal pain and 50.81% of them had accompanied systemic symptoms. In contrary, only 9.57% of MH had systemic symptoms. Interestingly, both tumours were more commonly found in the right hepatic lobe. The prognosis of these two entities was quite different, 41/103 (39.81%) of UES died, whereas only 7/110 (6.36%) cases with MH died. UES required additional chemotherapy whereas MH did not. With the limited information, some authors suggested that the ultrasonography findings were better concordant with the histology than computed tomography or magnetic resonance imaging. 54.9% UES patients' tumour was solid and only 30.36% were cystic. For MH, there was no significant difference in the nature of tumour. Conclusion: Similar imaging appearance and possible pathological overlap between UES and MH makes the initial diagnosis difficult to be established. Surgical biopsy and excision remained mandatory to confirm the diagnosis and to guide the subsequent treatment option. © 2018, Medcom Limited. All rights reserved.-
dc.languageeng-
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp-
dc.relation.ispartofHong Kong Journal of Paediatrics (New series)-
dc.subjectChildren-
dc.subjectEmbryonal sarcoma-
dc.subjectLiver tumour-
dc.subjectMesenchymal hamartoma-
dc.titleSolid liver tumours with cystic appearance: do they have the same outcome?-
dc.typeArticle-
dc.identifier.emailKhong, PL: plkhong@hku.hk-
dc.identifier.emailChiang, AKS: chiangak@hku.hk-
dc.identifier.emailCheuk, KLD: klcheuk@hkucc.hku.hk-
dc.identifier.emailHa, SY: syha@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.authorityKhong, PL=rp00467-
dc.identifier.authorityChiang, AKS=rp00403-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.scopuseid_2-s2.0-85065580241-
dc.identifier.hkuros302624-
dc.identifier.volume24-
dc.identifier.issue2-
dc.identifier.spage70-
dc.identifier.epage75-
dc.publisher.placeHong Kong-

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