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Article: Linking dose delivery accuracy and planning target margin in radiosurgery based on dose-volume histograms derived from measurement-guided dose reconstruction

TitleLinking dose delivery accuracy and planning target margin in radiosurgery based on dose-volume histograms derived from measurement-guided dose reconstruction
Authors
Keywordsdose delivery quality assurance
measurement-guided dose reconstruction
planning target margin
qausi-3D dosimetry
radiosurgery
Issue Date2019
PublisherInstitute of Physics Publishing. The Journal's web site is located at http://www.iop.org/journals/pmb
Citation
Physics in Medicine and Biology, 2019, v. 64 n. 4, p. article no. 045009 How to Cite?
AbstractIn radiosurgery (SRS), the geometric uncertainties of machine-related delivery including image-guidance and hence the planning target volume (PTV) are often evaluated by the end-to-end gamma (γ) comparison that carries no information about the clinical relevance of deviations of individual SRS plans during delivery quality assurance (DQA). A proof-of-concept method was proposed to derive the PTV against both the plan- and the machine-specific delivery errors directly from the clinically relevant dose-volume histograms (DVHs) using measured-guided dose reconstruction (MGDR) during DQA. A liquid-filled detector array and a rotating phantom were used to measure sixteen arc-based radiosurgery treatments with 1 and 2 mm gross tumor volume (GTV)-to-PTV margins, producing MGDR-3D dose distribution on both the phantom and the patient CT for γ index and clinical DVH evaluations, respectively. The PTV was considered optimal when the MGDR showed the desired prescription dose coverage (V pres ) of the GTV (100% in this study). Associations of the binary V pres outcomes (
Persistent Identifierhttp://hdl.handle.net/10722/274918
ISSN
2017 Impact Factor: 2.665
2015 SCImago Journal Rankings: 1.577
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, KH-
dc.contributor.authorLeung, RW-
dc.contributor.authorLee, VW-
dc.contributor.authorWong, MY-
dc.contributor.authorChiang, CL-
dc.contributor.authorLaw, GM-
dc.contributor.authorBlanck, O-
dc.date.accessioned2019-09-10T02:31:35Z-
dc.date.available2019-09-10T02:31:35Z-
dc.date.issued2019-
dc.identifier.citationPhysics in Medicine and Biology, 2019, v. 64 n. 4, p. article no. 045009-
dc.identifier.issn0031-9155-
dc.identifier.urihttp://hdl.handle.net/10722/274918-
dc.description.abstractIn radiosurgery (SRS), the geometric uncertainties of machine-related delivery including image-guidance and hence the planning target volume (PTV) are often evaluated by the end-to-end gamma (γ) comparison that carries no information about the clinical relevance of deviations of individual SRS plans during delivery quality assurance (DQA). A proof-of-concept method was proposed to derive the PTV against both the plan- and the machine-specific delivery errors directly from the clinically relevant dose-volume histograms (DVHs) using measured-guided dose reconstruction (MGDR) during DQA. A liquid-filled detector array and a rotating phantom were used to measure sixteen arc-based radiosurgery treatments with 1 and 2 mm gross tumor volume (GTV)-to-PTV margins, producing MGDR-3D dose distribution on both the phantom and the patient CT for γ index and clinical DVH evaluations, respectively. The PTV was considered optimal when the MGDR showed the desired prescription dose coverage (V pres ) of the GTV (100% in this study). Associations of the binary V pres outcomes (<or  =100%) of the GTV with the acceptance level of percent γ pass rate (γPR%) at 90 versus 95% were assessed. Further receiver operator characteristic (ROC) analysis was performed to assess the distance-to-agreement (DTA) and local dose difference (ΔD) criteria that may be suitable for treatment acceptance. From the MGDR, 100% GTV V pres was achieved in 68.8% and 100% of plans with 1 and 2 mm PTV, respectively. V pres outcomes were neither associated with γPR% at 1–2 mm DTA and 1%–3% ΔD nor the acceptance level for MGDR in the patient CT. ROC analysis shows statistically significant AUC values from 0.78–0.84 and 0.79–0.80 for MGDR phantom and patient doses, respectively. DQA by MGDR-DVH objectives offers the unique opportunity of direct assessment of the dose delivery accuracy and hence the optimal PTV without subject to the statistical correlation between γPR% and clinical metrics. Based on multi-criteria DVH objectives, clinical decision can be instantly made to adjust the treatment plan prescription.-
dc.languageeng-
dc.publisherInstitute of Physics Publishing. The Journal's web site is located at http://www.iop.org/journals/pmb-
dc.relation.ispartofPhysics in Medicine and Biology-
dc.rightsPhysics in Medicine and Biology. Copyright © Institute of Physics Publishing.-
dc.rightsThis is an author-created, un-copyedited version of an article published in [insert name of journal]. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at http://dx.doi.org/[insert DOI].-
dc.subjectdose delivery quality assurance-
dc.subjectmeasurement-guided dose reconstruction-
dc.subjectplanning target margin-
dc.subjectqausi-3D dosimetry-
dc.subjectradiosurgery-
dc.titleLinking dose delivery accuracy and planning target margin in radiosurgery based on dose-volume histograms derived from measurement-guided dose reconstruction-
dc.typeArticle-
dc.identifier.emailChiang, CL: chiangcl@hku.hk-
dc.identifier.authorityChiang, CL=rp02241-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1088/1361-6560/aafd47-
dc.identifier.pmid30630157-
dc.identifier.scopuseid_2-s2.0-85061272463-
dc.identifier.hkuros303260-
dc.identifier.volume64-
dc.identifier.issue4-
dc.identifier.spagearticle no. 045009-
dc.identifier.epagearticle no. 045009-
dc.identifier.isiWOS:000458375200001-
dc.publisher.placeUnited Kingdom-

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