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Article: Clinical, immunological and bacteriological characteristics of H7N9 patients nosocomially co-infected by Acinetobacter Baumannii: a case control study

TitleClinical, immunological and bacteriological characteristics of H7N9 patients nosocomially co-infected by Acinetobacter Baumannii: a case control study
Authors
KeywordsAvian influenza A(H7N9) virus
Acinetobacter baumannii
Extensively drug-resistant bacteria
Nosocomial infection
Pneumonia
Issue Date2018
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
BMC Infectious Diseases, 2018, v. 18, p. article no. 64 How to Cite?
AbstractBackground: Bacterial co-infection of patients suffering from influenza pneumonia is a key element that increases morbidity and mortality. The occurrence of Acinetobacter baumannii co-infection in patients with avian influenza A (H7N9) virus infection has been described as one of the most prevalent bacterial co-infections. However, the clinical and laboratory features of this entity of H7N9 and A. baumannii co-infection have not been systematically investigated. Methods: We collected clinical and laboratory data from laboratory-confirmed H7N9 cases co-infected by A. baumannii. H7N9 patients without bacterial co-infection and patients with A. baumannii-related pneumonia in the same hospital during the same period were recruited as controls. The antibiotic resistance features and the corresponding genome determinants of A. baumannii and the immune responses of the patients were tested through the respiratory and peripheral blood specimens. Results: Invasive mechanical ventilation was the most significant risk factor for the nosocomial A. baumannii co-infection in H7N9 patients. The co-infection resulted in severe clinical manifestation which was associated with the dysregulation of immune responses including deranged T-cell counts, antigen-specific T-cell responses and plasma cytokines. The emergence of genome variations of extensively drug-resistant A. baumannii associated with acquired polymyxin resistance contributed to the fatal outcome of a co-infected patient. Conclusions: The co-infection of H7N9 patients by extensively drug-resistant A. baumannii with H7N9 infection is an important issue which deserves attention. The dysfunctions of immune responses were associated with the co-infection and were correlated with the disease severity. These data provide useful reference for the diagnosis and treatment of H7N9 infection.
Persistent Identifierhttp://hdl.handle.net/10722/274607
ISSN
2017 Impact Factor: 2.62
2015 SCImago Journal Rankings: 1.510
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, WJ-
dc.contributor.authorZou, R-
dc.contributor.authorHu, Y-
dc.contributor.authorZhao, M-
dc.contributor.authorQuan, C-
dc.contributor.authorTan, S-
dc.contributor.authorLuo, K-
dc.contributor.authorYuan, J-
dc.contributor.authorZheng, H-
dc.contributor.authorLiu, J-
dc.contributor.authorLiu, M-
dc.contributor.authorBi, Y-
dc.contributor.authorYan, J-
dc.contributor.authorZhu, B-
dc.contributor.authorWang, D-
dc.contributor.authorWu, G-
dc.contributor.authorLiu, L-
dc.contributor.authorYuen, KY-
dc.contributor.authorGao, GF-
dc.contributor.authorLiu, Y-
dc.date.accessioned2019-08-18T15:05:12Z-
dc.date.available2019-08-18T15:05:12Z-
dc.date.issued2018-
dc.identifier.citationBMC Infectious Diseases, 2018, v. 18, p. article no. 64-
dc.identifier.issn1471-2334-
dc.identifier.urihttp://hdl.handle.net/10722/274607-
dc.description.abstractBackground: Bacterial co-infection of patients suffering from influenza pneumonia is a key element that increases morbidity and mortality. The occurrence of Acinetobacter baumannii co-infection in patients with avian influenza A (H7N9) virus infection has been described as one of the most prevalent bacterial co-infections. However, the clinical and laboratory features of this entity of H7N9 and A. baumannii co-infection have not been systematically investigated. Methods: We collected clinical and laboratory data from laboratory-confirmed H7N9 cases co-infected by A. baumannii. H7N9 patients without bacterial co-infection and patients with A. baumannii-related pneumonia in the same hospital during the same period were recruited as controls. The antibiotic resistance features and the corresponding genome determinants of A. baumannii and the immune responses of the patients were tested through the respiratory and peripheral blood specimens. Results: Invasive mechanical ventilation was the most significant risk factor for the nosocomial A. baumannii co-infection in H7N9 patients. The co-infection resulted in severe clinical manifestation which was associated with the dysregulation of immune responses including deranged T-cell counts, antigen-specific T-cell responses and plasma cytokines. The emergence of genome variations of extensively drug-resistant A. baumannii associated with acquired polymyxin resistance contributed to the fatal outcome of a co-infected patient. Conclusions: The co-infection of H7N9 patients by extensively drug-resistant A. baumannii with H7N9 infection is an important issue which deserves attention. The dysfunctions of immune responses were associated with the co-infection and were correlated with the disease severity. These data provide useful reference for the diagnosis and treatment of H7N9 infection.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/-
dc.relation.ispartofBMC Infectious Diseases-
dc.rightsBMC Infectious Diseases. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAvian influenza A(H7N9) virus-
dc.subjectAcinetobacter baumannii-
dc.subjectExtensively drug-resistant bacteria-
dc.subjectNosocomial infection-
dc.subjectPneumonia-
dc.titleClinical, immunological and bacteriological characteristics of H7N9 patients nosocomially co-infected by Acinetobacter Baumannii: a case control study-
dc.typeArticle-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12879-018-3447-4-
dc.identifier.pmid30551738-
dc.identifier.pmcidPMC6295110-
dc.identifier.scopuseid_2-s2.0-85058523002-
dc.identifier.hkuros301141-
dc.identifier.volume18-
dc.identifier.spagearticle no. 64-
dc.identifier.epagearticle no. 64-
dc.publisher.placeUnited Kingdom-

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