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Article: Exercise training improves motor skill learning via selective activation of mTOR

TitleExercise training improves motor skill learning via selective activation of mTOR
Authors
Issue Date2019
PublisherAmerican Association for the Advancement of Science: Science Advances. The Journal's web site is located at http://www.scienceadvances.org/
Citation
Science Advances, 2019, v. 5 n. 7, article no. eaaw1888 How to Cite?
AbstractPhysical exercise improves learning and memory, but little in vivo evidence has been provided to illustrate the molecular mechanisms. Here, we show that chronic treadmill exercise activates the mechanistic target of rapamycin (mTOR) pathway in mouse motor cortex. Both ex vivo and in vivo recordings suggest that mTOR activation leads to potentiated postsynaptic excitation and enhanced neuronal activity of layer 5 pyramidal neurons after exercise, in association with increased oligodendrogenesis and axonal myelination. Exercise training also increases dendritic spine formation and motor learning. Together, exercise activates mTOR pathway, which is necessary for spinogenesis, neuronal activation, and axonal myelination leading to improved motor learning. This model provides new insights for neural network adaptations through exercises and supports the intervention of cognitive deficits using exercise training.
Persistent Identifierhttp://hdl.handle.net/10722/274584
ISSN
2019 Impact Factor: 13.116
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, K-
dc.contributor.authorZheng, Y-
dc.contributor.authorWei, J-
dc.contributor.authorOuyang, H-
dc.contributor.authorHuang, X-
dc.contributor.authorZhang, F-
dc.contributor.authorLai, SWC-
dc.contributor.authorRen, C-
dc.contributor.authorSo, KF-
dc.contributor.authorZhang, L-
dc.date.accessioned2019-08-18T15:04:42Z-
dc.date.available2019-08-18T15:04:42Z-
dc.date.issued2019-
dc.identifier.citationScience Advances, 2019, v. 5 n. 7, article no. eaaw1888-
dc.identifier.issn2375-2548-
dc.identifier.urihttp://hdl.handle.net/10722/274584-
dc.description.abstractPhysical exercise improves learning and memory, but little in vivo evidence has been provided to illustrate the molecular mechanisms. Here, we show that chronic treadmill exercise activates the mechanistic target of rapamycin (mTOR) pathway in mouse motor cortex. Both ex vivo and in vivo recordings suggest that mTOR activation leads to potentiated postsynaptic excitation and enhanced neuronal activity of layer 5 pyramidal neurons after exercise, in association with increased oligodendrogenesis and axonal myelination. Exercise training also increases dendritic spine formation and motor learning. Together, exercise activates mTOR pathway, which is necessary for spinogenesis, neuronal activation, and axonal myelination leading to improved motor learning. This model provides new insights for neural network adaptations through exercises and supports the intervention of cognitive deficits using exercise training.-
dc.languageeng-
dc.publisherAmerican Association for the Advancement of Science: Science Advances. The Journal's web site is located at http://www.scienceadvances.org/-
dc.relation.ispartofScience Advances-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleExercise training improves motor skill learning via selective activation of mTOR-
dc.typeArticle-
dc.identifier.emailLai, SWC: coraswl@hku.hk-
dc.identifier.authorityLai, SWC=rp01895-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1126/sciadv.aaw1888-
dc.identifier.pmid31281888-
dc.identifier.hkuros302157-
dc.identifier.volume5-
dc.identifier.issue7-
dc.identifier.spagearticle no. eaaw1888-
dc.identifier.epagearticle no. eaaw1888-
dc.identifier.isiWOS:000478770400054-
dc.publisher.placeUnited States-

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