File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients

TitleOsteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients
Authors
Keywordsbone–vascular axis
calcification
conduction disorders
osteocalcin
osteogenic endothelial progenitor cells
Issue Date2019
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1542-474X
Citation
Annals of Noninvasive Electrocardiology, 2019, v. 24 n. 5, article no. e12651 How to Cite?
AbstractBackground: Osteogenic circulating endothelial progenitor cells (EPC) play a pathogenic role in cardiovascular system degeneration through promulgating vasculature calcification, but its role in conduction disorders as part of the cardiovascular degenerative continuum remained unknown. Aim: To investigate the role of osteocalcin (OCN)-expressing circulating EPCs in cardiac conduction disorders in the unique clinical sample of rheumatoid arthritis (RA) susceptible to both abnormal bone metabolism and cardiac conduction disorders. Methods: We performed flow cytometry studies in 134 consecutive asymptomatic patients with rheumatoid arthritis to derive osteogenic circulating OCN-positive (OCN+) CD34+KDR+ vs. CD34+CD133+KDR+ conventional EPC. Study endpoint was the prespecified combined endpoint of electrocardiographic conduction abnormalities. Results: Total prevalence of cardiac conduction abnormality was 9% (n = 12). All patients except one had normal sinus rhythm. One patient had atrial fibrillation. No patient had advanced atrioventricular (AV) block. Prevalence of first-degree heart block (>200 ms), widened QRS duration (>120 ms) and right bundle branch block were 6.7%, 2.1%, and 2.2% respectively. Circulating osteogenic OCN + CD34 + KDR + EPCs were significantly higher among patients with cardiac conduction abnormalities (p = 0.039). Elevated OCN + CD34 + KDR + EPCs> 75th percentile was associated with higher prevalence of cardiac conduction abnormalities (58.3% vs. 20.02%, p = 0.003). Adjusted for potential confounders, elevated OCN + CD34 + KDR + EPCs> 75th percentile remained independently associated with increased risk of cardiac conduction abnormalities (OR = 4.4 [95%CI 1.2–16.4], p = 0.028). No significant relation was found between conventional EPCs CD34+CD133+KDR+ and conduction abnormalities (p = 0.36). Conclusions: Elevated osteogenic OCN + CD34 + KDR + EPCs are independently associated with the presence of electrocardiographic conduction abnormalities in patients with rheumatoid arthritis, unveiling a potential novel pathophysiological mechanism. © 2019 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/274542
ISSN
2015 SCImago Journal Rankings: 0.531

 

DC FieldValueLanguage
dc.contributor.authorChan, YH-
dc.contributor.authorNgai, MC-
dc.contributor.authorChen, Y-
dc.contributor.authorWu, M-
dc.contributor.authorYu, Y-
dc.contributor.authorZhen, Z-
dc.contributor.authorLai, KWH-
dc.contributor.authorCheung, TT-
dc.contributor.authorHo, LM-
dc.contributor.authorChung, HY-
dc.contributor.authorLau, WCS-
dc.contributor.authorLau, CP-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2019-08-18T15:03:47Z-
dc.date.available2019-08-18T15:03:47Z-
dc.date.issued2019-
dc.identifier.citationAnnals of Noninvasive Electrocardiology, 2019, v. 24 n. 5, article no. e12651-
dc.identifier.issn1542-474X-
dc.identifier.urihttp://hdl.handle.net/10722/274542-
dc.description.abstractBackground: Osteogenic circulating endothelial progenitor cells (EPC) play a pathogenic role in cardiovascular system degeneration through promulgating vasculature calcification, but its role in conduction disorders as part of the cardiovascular degenerative continuum remained unknown. Aim: To investigate the role of osteocalcin (OCN)-expressing circulating EPCs in cardiac conduction disorders in the unique clinical sample of rheumatoid arthritis (RA) susceptible to both abnormal bone metabolism and cardiac conduction disorders. Methods: We performed flow cytometry studies in 134 consecutive asymptomatic patients with rheumatoid arthritis to derive osteogenic circulating OCN-positive (OCN+) CD34+KDR+ vs. CD34+CD133+KDR+ conventional EPC. Study endpoint was the prespecified combined endpoint of electrocardiographic conduction abnormalities. Results: Total prevalence of cardiac conduction abnormality was 9% (n = 12). All patients except one had normal sinus rhythm. One patient had atrial fibrillation. No patient had advanced atrioventricular (AV) block. Prevalence of first-degree heart block (>200 ms), widened QRS duration (>120 ms) and right bundle branch block were 6.7%, 2.1%, and 2.2% respectively. Circulating osteogenic OCN + CD34 + KDR + EPCs were significantly higher among patients with cardiac conduction abnormalities (p = 0.039). Elevated OCN + CD34 + KDR + EPCs> 75th percentile was associated with higher prevalence of cardiac conduction abnormalities (58.3% vs. 20.02%, p = 0.003). Adjusted for potential confounders, elevated OCN + CD34 + KDR + EPCs> 75th percentile remained independently associated with increased risk of cardiac conduction abnormalities (OR = 4.4 [95%CI 1.2–16.4], p = 0.028). No significant relation was found between conventional EPCs CD34+CD133+KDR+ and conduction abnormalities (p = 0.36). Conclusions: Elevated osteogenic OCN + CD34 + KDR + EPCs are independently associated with the presence of electrocardiographic conduction abnormalities in patients with rheumatoid arthritis, unveiling a potential novel pathophysiological mechanism. © 2019 Wiley Periodicals, Inc.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1542-474X-
dc.relation.ispartofAnnals of Noninvasive Electrocardiology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectbone–vascular axis-
dc.subjectcalcification-
dc.subjectconduction disorders-
dc.subjectosteocalcin-
dc.subjectosteogenic endothelial progenitor cells-
dc.titleOsteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients-
dc.typeArticle-
dc.identifier.emailChen, Y: cheny818@hku.hk-
dc.identifier.emailWu, M: wmz513@hku.hk-
dc.identifier.emailLai, KWH: kwhlai@hku.hk-
dc.identifier.emailCheung, TT: tcheungt@HKUCC-COM.hku.hk-
dc.identifier.emailHo, LM: lmho@hku.hk-
dc.identifier.emailChung, HY: jameschy@hku.hk-
dc.identifier.emailLau, WCS: cslau@hku.hk-
dc.identifier.emailLau, CP: cplau@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityCheung, TT=rp01682-
dc.identifier.authorityHo, LM=rp00360-
dc.identifier.authorityChung, HY=rp02330-
dc.identifier.authorityLau, WCS=rp01348-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/anec.12651-
dc.identifier.scopuseid_2-s2.0-85064811456-
dc.identifier.hkuros302256-
dc.identifier.volume24-
dc.identifier.issue5-
dc.identifier.spagearticle no. e12651-
dc.identifier.epagearticle no. e12651-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats