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Article: Clinical prognostic model for older patients with advanced non-small cell lung cancer

TitleClinical prognostic model for older patients with advanced non-small cell lung cancer
Authors
KeywordsPrognostic models
Older patients
Survival
Non-small cell lung cancer
Geriatric oncology
Issue Date2019
PublisherElsevier Inc. The Journal's web site is located at http://www.geriatriconcology.net/
Citation
Journal of Geriatric Oncology, 2019, v. 10 n. 4, p. 555-559 How to Cite?
AbstractBackground: Older patients with non-small cell lung cancer (NSCLC) are often not prescribed standard therapy. It is important to know which older patients would be candidates for aggressive therapy based on their prognosis, and to develop a model that can help determine prognosis. Methods: Data on older patients (≥70 years) enrolled on 38 NCI cooperative group trials of advanced NSCLC from 1991 to 2011 were analyzed. Multivariable Cox PH model was built with a stepwise selection. We derived a prognostic score using the estimated Cox PH regression coefficient. We then calculated the area under receiver operating characteristic (ROC) curve of survival in the testing set. Results: The final analysis included 1467 patients, who were randomly divided into a training (n = 963) and a testing set (n = 504). The prognostic risk score was calculated as: 3 (if male) + 3 (if PS = 1) + 8 (if PS = 2) + 11 (if initial stage = IV) + 4 (if weight loss). Patients were classified into two prognostic groups: good (0–8) and poor (≥9). The median survival in the two groups in the testing set were 13.15 (95% CI, 10.82–15.91) and 8.52 months (95% CI, 7.5–9.63), respectively. The model had area under the 1-year and 2-year ROCs (0.6 and 0.65, respectively) that were higher than existing models. Conclusions: Male gender, poor performance status, distant metastases and recent weight loss predict for poor overall survival (OS) in older patients with advanced NSCLC. This study proposes a simple prognostic model for older adults with advanced NSCLC.
Persistent Identifierhttp://hdl.handle.net/10722/274528
ISSN
2017 Impact Factor: 3.359
2015 SCImago Journal Rankings: 1.092

 

DC FieldValueLanguage
dc.contributor.authorGanti, AK-
dc.contributor.authorWang, X-
dc.contributor.authorStinchcombe, T-
dc.contributor.authorWANG, Y-
dc.contributor.authorBradley, J-
dc.contributor.authorCohen, H-
dc.contributor.authorKelly, K-
dc.contributor.authorPaulus, R-
dc.contributor.authorRamalingam, SS-
dc.contributor.authorVokes, EE-
dc.contributor.authorPang, H-
dc.date.accessioned2019-08-18T15:03:29Z-
dc.date.available2019-08-18T15:03:29Z-
dc.date.issued2019-
dc.identifier.citationJournal of Geriatric Oncology, 2019, v. 10 n. 4, p. 555-559-
dc.identifier.issn1879-4068-
dc.identifier.urihttp://hdl.handle.net/10722/274528-
dc.description.abstractBackground: Older patients with non-small cell lung cancer (NSCLC) are often not prescribed standard therapy. It is important to know which older patients would be candidates for aggressive therapy based on their prognosis, and to develop a model that can help determine prognosis. Methods: Data on older patients (≥70 years) enrolled on 38 NCI cooperative group trials of advanced NSCLC from 1991 to 2011 were analyzed. Multivariable Cox PH model was built with a stepwise selection. We derived a prognostic score using the estimated Cox PH regression coefficient. We then calculated the area under receiver operating characteristic (ROC) curve of survival in the testing set. Results: The final analysis included 1467 patients, who were randomly divided into a training (n = 963) and a testing set (n = 504). The prognostic risk score was calculated as: 3 (if male) + 3 (if PS = 1) + 8 (if PS = 2) + 11 (if initial stage = IV) + 4 (if weight loss). Patients were classified into two prognostic groups: good (0–8) and poor (≥9). The median survival in the two groups in the testing set were 13.15 (95% CI, 10.82–15.91) and 8.52 months (95% CI, 7.5–9.63), respectively. The model had area under the 1-year and 2-year ROCs (0.6 and 0.65, respectively) that were higher than existing models. Conclusions: Male gender, poor performance status, distant metastases and recent weight loss predict for poor overall survival (OS) in older patients with advanced NSCLC. This study proposes a simple prognostic model for older adults with advanced NSCLC.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.geriatriconcology.net/-
dc.relation.ispartofJournal of Geriatric Oncology-
dc.subjectPrognostic models-
dc.subjectOlder patients-
dc.subjectSurvival-
dc.subjectNon-small cell lung cancer-
dc.subjectGeriatric oncology-
dc.titleClinical prognostic model for older patients with advanced non-small cell lung cancer-
dc.typeArticle-
dc.identifier.emailPang, H: herbpang@hku.hk-
dc.identifier.authorityPang, H=rp01857-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jgo.2019.02.007-
dc.identifier.pmid30797707-
dc.identifier.scopuseid_2-s2.0-85061692376-
dc.identifier.hkuros301760-
dc.identifier.volume10-
dc.identifier.issue4-
dc.identifier.spage555-
dc.identifier.epage559-
dc.publisher.placeUnited States-

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