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- Publisher Website: 10.1002/ajmg.c.31696
- Scopus: eid_2-s2.0-85063333475
- PMID: 30897304
- WOS: WOS:000470898600014
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Article: Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility
Title | Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility |
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Authors | |
Keywords | association studies East Asian genetic susceptibility population differences systemic lupus erythematosus |
Issue Date | 2019 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:2/ |
Citation | American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2019, v. 181 n. 2, p. 262-268 How to Cite? |
Abstract | Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with extreme clinical heterogeneity and significant differences between populations. East Asian populations are known to have higher prevalence and more severe clinical manifestations for SLE than Europeans. The difference could be the result of genetic and environmental factors, and the interactions between them. Thus, identifying genetic associations from diverse populations provides an opportunity to better understand the genetic architecture of this heterogeneous disease. It is also necessary to elucidate population differences and to apply the findings in future stratified treatment of the disease, with ethnicity likely a major factor to consider. Indeed, it has shown that there are significant differences between East Asians and European populations in several genetic loci for SLE. Genetic studies on SLE are very active in East Asian countries and there have been close collaborations among scientists in this region. Here, we document some work done in this region on SLE genetic research and discuss the aspect of population differences. |
Persistent Identifier | http://hdl.handle.net/10722/274425 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 1.009 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Y | - |
dc.contributor.author | Lau, YL | - |
dc.contributor.author | Yang, W | - |
dc.date.accessioned | 2019-08-18T15:01:28Z | - |
dc.date.available | 2019-08-18T15:01:28Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2019, v. 181 n. 2, p. 262-268 | - |
dc.identifier.issn | 1552-4868 | - |
dc.identifier.uri | http://hdl.handle.net/10722/274425 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with extreme clinical heterogeneity and significant differences between populations. East Asian populations are known to have higher prevalence and more severe clinical manifestations for SLE than Europeans. The difference could be the result of genetic and environmental factors, and the interactions between them. Thus, identifying genetic associations from diverse populations provides an opportunity to better understand the genetic architecture of this heterogeneous disease. It is also necessary to elucidate population differences and to apply the findings in future stratified treatment of the disease, with ethnicity likely a major factor to consider. Indeed, it has shown that there are significant differences between East Asians and European populations in several genetic loci for SLE. Genetic studies on SLE are very active in East Asian countries and there have been close collaborations among scientists in this region. Here, we document some work done in this region on SLE genetic research and discuss the aspect of population differences. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:2/ | - |
dc.relation.ispartof | American Journal of Medical Genetics Part C: Seminars in Medical Genetics | - |
dc.rights | Preprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | association studies | - |
dc.subject | East Asian | - |
dc.subject | genetic susceptibility | - |
dc.subject | population differences | - |
dc.subject | systemic lupus erythematosus | - |
dc.title | Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility | - |
dc.type | Article | - |
dc.identifier.email | Wang, Y: yfwangbm@connect.hku.hk | - |
dc.identifier.email | Lau, YL: lauylung@hku.hk | - |
dc.identifier.email | Yang, W: yangwl@hku.hk | - |
dc.identifier.authority | Lau, YL=rp00361 | - |
dc.identifier.authority | Yang, W=rp00524 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/ajmg.c.31696 | - |
dc.identifier.pmid | 30897304 | - |
dc.identifier.scopus | eid_2-s2.0-85063333475 | - |
dc.identifier.hkuros | 301790 | - |
dc.identifier.volume | 181 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 262 | - |
dc.identifier.epage | 268 | - |
dc.identifier.isi | WOS:000470898600014 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1552-4868 | - |