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Article: Engineering embolic microparticles from a periodically-pulsating charged liquid meniscus

TitleEngineering embolic microparticles from a periodically-pulsating charged liquid meniscus
Authors
KeywordsElectrospray
Embolic microparticles
Micro-dripping mode
Pulsating meniscus
Issue Date2018
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ces
Citation
Chemical Engineering Science, 2018, v. 183, p. 13-19 How to Cite?
AbstractA commercial-scale generation of uniform and well-controlled soft microparticles is critical for therapeutic embolization, a minimally invasive, nonsurgical interventional therapeutic technique for the treatment of various conditions, including tumors, vascular lesions and hemorrhages. We report the generation of required embolic microparticles from an electrified meniscus of the precursor alginate solution. A micro-dripping regime is identified with electric Bond number BE being from 0.3 to 1 and Weber number We < 1, where the conical tip of the charged meniscus emits a single yet fine droplet periodically. The droplet diameter dd and its generation frequency f scale with the dimensionless controlling parameters in the form of dd∼q0.5, f∼q-0.15BE0.67 in this regime, with q being the dimensionless flow rate. Our results are valuable for effective production of therapeutic microparticles on a commercial scale from precursor solution of similar physical properties. © 2018 Elsevier Ltd
Persistent Identifierhttp://hdl.handle.net/10722/274411
ISSN
2017 Impact Factor: 3.306
2015 SCImago Journal Rankings: 1.073

 

DC FieldValueLanguage
dc.contributor.authorTian, X-
dc.contributor.authorKong, T-
dc.contributor.authorZhu, P-
dc.contributor.authorKANG, Z-
dc.contributor.authorLEI, L-
dc.contributor.authorTang, X-
dc.contributor.authorWang, L-
dc.date.accessioned2019-08-18T15:01:13Z-
dc.date.available2019-08-18T15:01:13Z-
dc.date.issued2018-
dc.identifier.citationChemical Engineering Science, 2018, v. 183, p. 13-19-
dc.identifier.issn0009-2509-
dc.identifier.urihttp://hdl.handle.net/10722/274411-
dc.description.abstractA commercial-scale generation of uniform and well-controlled soft microparticles is critical for therapeutic embolization, a minimally invasive, nonsurgical interventional therapeutic technique for the treatment of various conditions, including tumors, vascular lesions and hemorrhages. We report the generation of required embolic microparticles from an electrified meniscus of the precursor alginate solution. A micro-dripping regime is identified with electric Bond number BE being from 0.3 to 1 and Weber number We < 1, where the conical tip of the charged meniscus emits a single yet fine droplet periodically. The droplet diameter dd and its generation frequency f scale with the dimensionless controlling parameters in the form of dd∼q0.5, f∼q-0.15BE0.67 in this regime, with q being the dimensionless flow rate. Our results are valuable for effective production of therapeutic microparticles on a commercial scale from precursor solution of similar physical properties. © 2018 Elsevier Ltd-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ces-
dc.relation.ispartofChemical Engineering Science-
dc.subjectElectrospray-
dc.subjectEmbolic microparticles-
dc.subjectMicro-dripping mode-
dc.subjectPulsating meniscus-
dc.titleEngineering embolic microparticles from a periodically-pulsating charged liquid meniscus-
dc.typeArticle-
dc.identifier.emailTian, X: tianxw@hku.hk-
dc.identifier.emailZhu, P: pazhu@hku.hk-
dc.identifier.emailTang, X: tangxin@connect.hku.hk-
dc.identifier.emailWang, L: lqwang@hku.hk-
dc.identifier.authorityWang, L=rp00184-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ces.2018.02.040-
dc.identifier.scopuseid_2-s2.0-85042853713-
dc.identifier.hkuros301678-
dc.identifier.volume183-
dc.identifier.spage13-
dc.identifier.epage19-
dc.publisher.placeUnited Kingdom-

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