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Article: Meta-analysis of voxel-based morphometry studies of gray matter abnormalities in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis

TitleMeta-analysis of voxel-based morphometry studies of gray matter abnormalities in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis
Authors
KeywordsMeta-analysis
Mesial temporal lobe epilepsy
Hippocampal sclerosis
Gray matter volume
Voxel-based morphometry
Issue Date2018
PublisherSpringer New York LLC.
Citation
Brain Imaging and Behavior, 2018, v. 12 n. 5, p. 1497-1503 How to Cite?
AbstractWe aimed to perform a meta-analysis to systematically determine the most consistent regions of gray matter volume (GMV) abnormality in patients of unilateral mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), and to reveal the difference of GMV abnormality between the patients with left-sided and right-sided MTLE-HS. A comprehensive and systematic search was performed in PubMed for voxel-based morphometry (VBM) studies of MTLE-HS. A total of 12 MTLE-HS studies, including 9 left-sided MTLE-HS (LMTLE-HS) and 8 right-sided MTLE-HS (RMTLE-HS) studies were included. The activation likelihood estimation (ALE) method was applied in our meta-analysis. Compared to the healthy controls, MTLE-HS patients showed significant GMV decrease in the parahippocampal gyrus, left pulvinar and right pyramis. For LMTLE-HS, the most consistent GMV decrease was detected in the left parahippocampal gyrus. For RMTLE-HS, the most consistent GMV decrease was found in the right parahippocampal gyrus. No shared regions of significant GMV reduction were found between LMTLE-HS and RMTLE-HS either. This meta-analysis revealed that MTLE-HS patients had significant GMV reduction even beyond the hippocampus, and the subtypes showed distinct reduction patterns. Our findings, if were further verified with larger samples, would have implications for the clinical diagnosis of MTLE-HS.
Persistent Identifierhttp://hdl.handle.net/10722/274112
ISSN
2017 Impact Factor: 3.719
2015 SCImago Journal Rankings: 1.980

 

DC FieldValueLanguage
dc.contributor.authorZheng, L-
dc.contributor.authorBin, G-
dc.contributor.authorZeng, H-
dc.contributor.authorZou, D-
dc.contributor.authorGao, J-
dc.contributor.authorZhang, J-
dc.contributor.authorHuang, B-
dc.date.accessioned2019-08-18T14:55:20Z-
dc.date.available2019-08-18T14:55:20Z-
dc.date.issued2018-
dc.identifier.citationBrain Imaging and Behavior, 2018, v. 12 n. 5, p. 1497-1503-
dc.identifier.issn1931-7557-
dc.identifier.urihttp://hdl.handle.net/10722/274112-
dc.description.abstractWe aimed to perform a meta-analysis to systematically determine the most consistent regions of gray matter volume (GMV) abnormality in patients of unilateral mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), and to reveal the difference of GMV abnormality between the patients with left-sided and right-sided MTLE-HS. A comprehensive and systematic search was performed in PubMed for voxel-based morphometry (VBM) studies of MTLE-HS. A total of 12 MTLE-HS studies, including 9 left-sided MTLE-HS (LMTLE-HS) and 8 right-sided MTLE-HS (RMTLE-HS) studies were included. The activation likelihood estimation (ALE) method was applied in our meta-analysis. Compared to the healthy controls, MTLE-HS patients showed significant GMV decrease in the parahippocampal gyrus, left pulvinar and right pyramis. For LMTLE-HS, the most consistent GMV decrease was detected in the left parahippocampal gyrus. For RMTLE-HS, the most consistent GMV decrease was found in the right parahippocampal gyrus. No shared regions of significant GMV reduction were found between LMTLE-HS and RMTLE-HS either. This meta-analysis revealed that MTLE-HS patients had significant GMV reduction even beyond the hippocampus, and the subtypes showed distinct reduction patterns. Our findings, if were further verified with larger samples, would have implications for the clinical diagnosis of MTLE-HS.-
dc.languageeng-
dc.publisherSpringer New York LLC.-
dc.relation.ispartofBrain Imaging and Behavior-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/[insert DOI]-
dc.subjectMeta-analysis-
dc.subjectMesial temporal lobe epilepsy-
dc.subjectHippocampal sclerosis-
dc.subjectGray matter volume-
dc.subjectVoxel-based morphometry-
dc.titleMeta-analysis of voxel-based morphometry studies of gray matter abnormalities in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis-
dc.typeArticle-
dc.identifier.emailGao, J: galeng@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11682-017-9797-5-
dc.identifier.pmid29302917-
dc.identifier.scopuseid_2-s2.0-85040057689-
dc.identifier.hkuros301774-
dc.identifier.volume12-
dc.identifier.issue5-
dc.identifier.spage1497-
dc.identifier.epage1503-
dc.publisher.placeUnited States-

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