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Article: The changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China

TitleThe changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China
Authors
KeywordsChina
HIV-1
molecular epidemiology
transmitted drug resistance
Yunnan
Issue Date2018
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
Citation
Epidemiology and Infection, 2018, v. 146 n. 6, p. 775-781 How to Cite?
AbstractMultiple human immunodeficiency virus (HIV)-1 genotypes in China were first discovered in Yunnan Province before disseminating throughout the country. As the HIV-1 epidemic continues to expand in Yunnan, genetic characteristics and transmitted drug resistance (TDR) should be further investigated among the recently infected population. Among 2828 HIV-positive samples newly reported in the first quarter of 2014, 347 were identified as recent infections with BED-captured enzyme immunoassay (CEIA). Of them, 291 were successfully genotyped and identified as circulating recombinant form (CRF)08_BC (47.4%), unique recombinant forms (URFs) (18.2%), CRF01_AE (15.8%), CRF07_BC (14.4%), subtype C (2.7%), CRF55_01B (0.7%), subtype B (0.3%) and CRF64_BC (0.3%). CRF08_BC and CRF01_AE were the predominant genotypes among heterosexual and homosexual infections, respectively. CRF08_BC, URFs, CRF01_AE and CRF07_BC expanded with higher prevalence in central and eastern Yunnan. The recent common ancestor of CRF01_AE, CRF07_BC and CRF08_BC dated back to 1983.1, 1992.1 and 1989.5, respectively. The effective population sizes (EPS) for CRF01_AE and CRF07_BC increased exponentially during 1991–1999 and 1994–1999, respectively. The EPS for CRF08_BC underwent two exponential growth phases in 1994–1998 and 2001–2002. Lastly, TDR-associated mutations were identified in 1.8% of individuals. These findings not only enhance our understanding of HIV-1 evolution in Yunnan but also have implications for vaccine design and patient management strategies.
Persistent Identifierhttp://hdl.handle.net/10722/273978
ISSN
2017 Impact Factor: 2.044
2015 SCImago Journal Rankings: 1.320

 

DC FieldValueLanguage
dc.contributor.authorChen, M-
dc.contributor.authorJia, MH-
dc.contributor.authorMa, YL-
dc.contributor.authorLuo, HB-
dc.contributor.authorChen, HC-
dc.contributor.authorYang, CJ-
dc.contributor.authorDai, J-
dc.contributor.authorYang, L-
dc.contributor.authorDong, LJ-
dc.contributor.authorLu, R-
dc.contributor.authorSong, LJ-
dc.contributor.authorHan, Y-
dc.contributor.authorLu, JY-
dc.contributor.authorCheung, AKL-
dc.contributor.authorChen, ZW-
dc.contributor.authorLu, L-
dc.date.accessioned2019-08-18T14:52:35Z-
dc.date.available2019-08-18T14:52:35Z-
dc.date.issued2018-
dc.identifier.citationEpidemiology and Infection, 2018, v. 146 n. 6, p. 775-781-
dc.identifier.issn0950-2688-
dc.identifier.urihttp://hdl.handle.net/10722/273978-
dc.description.abstractMultiple human immunodeficiency virus (HIV)-1 genotypes in China were first discovered in Yunnan Province before disseminating throughout the country. As the HIV-1 epidemic continues to expand in Yunnan, genetic characteristics and transmitted drug resistance (TDR) should be further investigated among the recently infected population. Among 2828 HIV-positive samples newly reported in the first quarter of 2014, 347 were identified as recent infections with BED-captured enzyme immunoassay (CEIA). Of them, 291 were successfully genotyped and identified as circulating recombinant form (CRF)08_BC (47.4%), unique recombinant forms (URFs) (18.2%), CRF01_AE (15.8%), CRF07_BC (14.4%), subtype C (2.7%), CRF55_01B (0.7%), subtype B (0.3%) and CRF64_BC (0.3%). CRF08_BC and CRF01_AE were the predominant genotypes among heterosexual and homosexual infections, respectively. CRF08_BC, URFs, CRF01_AE and CRF07_BC expanded with higher prevalence in central and eastern Yunnan. The recent common ancestor of CRF01_AE, CRF07_BC and CRF08_BC dated back to 1983.1, 1992.1 and 1989.5, respectively. The effective population sizes (EPS) for CRF01_AE and CRF07_BC increased exponentially during 1991–1999 and 1994–1999, respectively. The EPS for CRF08_BC underwent two exponential growth phases in 1994–1998 and 2001–2002. Lastly, TDR-associated mutations were identified in 1.8% of individuals. These findings not only enhance our understanding of HIV-1 evolution in Yunnan but also have implications for vaccine design and patient management strategies.-
dc.languageeng-
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG-
dc.relation.ispartofEpidemiology and Infection-
dc.rightsEpidemiology and Infection. Copyright © Cambridge University Press.-
dc.rightsThis article has been published in a revised form in [Journal] [http://doi.org/XXX]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.-
dc.subjectChina-
dc.subjectHIV-1-
dc.subjectmolecular epidemiology-
dc.subjecttransmitted drug resistance-
dc.subjectYunnan-
dc.titleThe changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China-
dc.typeArticle-
dc.identifier.emailChen, ZW: zchenai@hku.hk-
dc.identifier.authorityChen, ZW=rp00243-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1017/S0950268818000389-
dc.identifier.pmid29534773-
dc.identifier.scopuseid_2-s2.0-85043679598-
dc.identifier.hkuros301456-
dc.identifier.volume146-
dc.identifier.issue6-
dc.identifier.spage775-
dc.identifier.epage781-
dc.publisher.placeUnited Kingdom-

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