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Article: 25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese

Title25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese
Authors
KeywordsVitamin D
Diabetes mellitus
Serum calcium
Epidemiological studies
Issue Date2019
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PHN
Citation
Public Health Nutrition, 2019, Epub, p. 1-7 How to Cite?
AbstractObjective: To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) and risk of incident diabetes in Hong Kong Chinese, after accounting for the effect of multiple bone- and mineral-related markers. Design: We conducted a retrospective study on the Hong Kong Osteoporosis Study cohort. Incident diabetes was ascertained using electronic medical records. Serum 25(OH)D was measured at baseline and its association with incident diabetes was evaluated using multivariable Cox proportional-hazard regression. Participants: Individuals (n 4342) aged 20 years or above (1395 men, 2947 women; mean age 54·3 (sd 16·5) years) from the Hong Kong Osteoporosis Study, who were free of diabetes at baseline, were included. Results: During 40 124·7 person-years of follow-up (a median of 9·2 years), 443 participants developed diabetes. Mean 25(OH)D was 63·34 (sd 13·07) nmol/l. Age-, sex- and BMI-adjusted Cox proportional-hazard regression showed no significant difference in the risk of incident diabetes between the lowest and the highest quintiles of 25(OH)D. In the analysis of the interaction effect between 25(OH)D and serum Ca, the interaction term did not affect the risk of incident diabetes significantly (P = 0·694). Similarly, there was no significant interaction of different subgroups (age, sex, BMI, femoral-neck T-score, serum Ca levels) with serum 25(OH)D. Conclusions: The present study finds that serum vitamin D level is not associated with the risk of incident diabetes in Hong Kong Chinese and this relationship is not modified by serum Ca level.
Persistent Identifierhttp://hdl.handle.net/10722/273936
ISSN
2019 Impact Factor: 3.182
2015 SCImago Journal Rankings: 0.995

 

DC FieldValueLanguage
dc.contributor.authorLeung, RYH-
dc.contributor.authorCheung, BMY-
dc.contributor.authorTan, KCB-
dc.contributor.authorKung, AWC-
dc.contributor.authorCheung, CL-
dc.date.accessioned2019-08-18T14:51:42Z-
dc.date.available2019-08-18T14:51:42Z-
dc.date.issued2019-
dc.identifier.citationPublic Health Nutrition, 2019, Epub, p. 1-7-
dc.identifier.issn1368-9800-
dc.identifier.urihttp://hdl.handle.net/10722/273936-
dc.description.abstractObjective: To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) and risk of incident diabetes in Hong Kong Chinese, after accounting for the effect of multiple bone- and mineral-related markers. Design: We conducted a retrospective study on the Hong Kong Osteoporosis Study cohort. Incident diabetes was ascertained using electronic medical records. Serum 25(OH)D was measured at baseline and its association with incident diabetes was evaluated using multivariable Cox proportional-hazard regression. Participants: Individuals (n 4342) aged 20 years or above (1395 men, 2947 women; mean age 54·3 (sd 16·5) years) from the Hong Kong Osteoporosis Study, who were free of diabetes at baseline, were included. Results: During 40 124·7 person-years of follow-up (a median of 9·2 years), 443 participants developed diabetes. Mean 25(OH)D was 63·34 (sd 13·07) nmol/l. Age-, sex- and BMI-adjusted Cox proportional-hazard regression showed no significant difference in the risk of incident diabetes between the lowest and the highest quintiles of 25(OH)D. In the analysis of the interaction effect between 25(OH)D and serum Ca, the interaction term did not affect the risk of incident diabetes significantly (P = 0·694). Similarly, there was no significant interaction of different subgroups (age, sex, BMI, femoral-neck T-score, serum Ca levels) with serum 25(OH)D. Conclusions: The present study finds that serum vitamin D level is not associated with the risk of incident diabetes in Hong Kong Chinese and this relationship is not modified by serum Ca level.-
dc.languageeng-
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PHN-
dc.relation.ispartofPublic Health Nutrition-
dc.rightsPublic Health Nutrition. Copyright © Cambridge University Press.-
dc.rightsThis article has been published in a revised form in [Journal] [http://doi.org/XXX]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.-
dc.subjectVitamin D-
dc.subjectDiabetes mellitus-
dc.subjectSerum calcium-
dc.subjectEpidemiological studies-
dc.title25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese-
dc.typeArticle-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.emailTan, KCB: kcbtan@hkucc.hku.hk-
dc.identifier.emailKung, AWC: awckung@hku.hk-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.authorityCheung, BMY=rp01321-
dc.identifier.authorityTan, KCB=rp00402-
dc.identifier.authorityKung, AWC=rp00368-
dc.identifier.authorityCheung, CL=rp01749-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1017/S1368980019000582-
dc.identifier.pmid31169100-
dc.identifier.scopuseid_2-s2.0-85066930040-
dc.identifier.hkuros301830-
dc.identifier.spage1-
dc.identifier.epage7-
dc.publisher.placeUnited Kingdom-

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