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Article: Circulating adipocyte fatty acid-binding protein levels predict the development of subclinical atherosclerosis in type 2 diabetes

TitleCirculating adipocyte fatty acid-binding protein levels predict the development of subclinical atherosclerosis in type 2 diabetes
Authors
KeywordsA-FABP
Atherosclerosis
Biomarker
Diabetes
Prediction
Issue Date2018
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jdiacomp
Citation
Journal of Diabetes and its Complications, 2018, v. 32 n. 12, p. 1100-1104 How to Cite?
AbstractObjective: The aim of this study was to investigate the prospective association of circulating adipocyte fatty acid-binding protein (A-FABP) levels with the development of subclinical atherosclerosis in patients with type 2 diabetes in an 8-year prospective study. Methods: A total of 170 patients with newly diagnosed type 2 diabetes were recruited in the study and 133 patients completed the follow-up of 8 years. Baseline plasma A-FABP levels were measured with enzyme-linked immunosorbent assays. The role of A-FABP in predicting the development of subclinical atherosclerosis over 8 years was analyzed using multiple logistic regression. Results: Of the 133 patients without subclinical atherosclerosis at baseline, a total of 100 had progressed to subclinical atherosclerosis over 8 years. Baseline A-FABP level was significantly higher in patients who had progressed to subclinical atherosclerosis at year 8 compared with ones who had not developed subclinical atherosclerosis after adjustment for sex (15.3 [12.1–23.2] versus 13.3 [10.0–18.9] ng/ml, P = 0.021). High baseline A-FABP level was an independent predictor for the development of subclinical atherosclerosis in patients with type 2 diabetes (odds ratio: 16.24, P = 0.022). Conclusions: Circulating A-FABP levels predict the development of subclinical atherosclerosis in type 2 diabetes patients.
Persistent Identifierhttp://hdl.handle.net/10722/273931
ISSN
2017 Impact Factor: 2.792
2015 SCImago Journal Rankings: 1.632

 

DC FieldValueLanguage
dc.contributor.authorXiao, Y-
dc.contributor.authorXiao, X-
dc.contributor.authorXu, A-
dc.contributor.authorChen, X-
dc.contributor.authorTang, W-
dc.contributor.authorZhou, Z-
dc.date.accessioned2019-08-18T14:51:36Z-
dc.date.available2019-08-18T14:51:36Z-
dc.date.issued2018-
dc.identifier.citationJournal of Diabetes and its Complications, 2018, v. 32 n. 12, p. 1100-1104-
dc.identifier.issn1056-8727-
dc.identifier.urihttp://hdl.handle.net/10722/273931-
dc.description.abstractObjective: The aim of this study was to investigate the prospective association of circulating adipocyte fatty acid-binding protein (A-FABP) levels with the development of subclinical atherosclerosis in patients with type 2 diabetes in an 8-year prospective study. Methods: A total of 170 patients with newly diagnosed type 2 diabetes were recruited in the study and 133 patients completed the follow-up of 8 years. Baseline plasma A-FABP levels were measured with enzyme-linked immunosorbent assays. The role of A-FABP in predicting the development of subclinical atherosclerosis over 8 years was analyzed using multiple logistic regression. Results: Of the 133 patients without subclinical atherosclerosis at baseline, a total of 100 had progressed to subclinical atherosclerosis over 8 years. Baseline A-FABP level was significantly higher in patients who had progressed to subclinical atherosclerosis at year 8 compared with ones who had not developed subclinical atherosclerosis after adjustment for sex (15.3 [12.1–23.2] versus 13.3 [10.0–18.9] ng/ml, P = 0.021). High baseline A-FABP level was an independent predictor for the development of subclinical atherosclerosis in patients with type 2 diabetes (odds ratio: 16.24, P = 0.022). Conclusions: Circulating A-FABP levels predict the development of subclinical atherosclerosis in type 2 diabetes patients.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jdiacomp-
dc.relation.ispartofJournal of Diabetes and its Complications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectA-FABP-
dc.subjectAtherosclerosis-
dc.subjectBiomarker-
dc.subjectDiabetes-
dc.subjectPrediction-
dc.titleCirculating adipocyte fatty acid-binding protein levels predict the development of subclinical atherosclerosis in type 2 diabetes-
dc.typeArticle-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.jdiacomp.2018.09.001-
dc.identifier.pmid30314766-
dc.identifier.scopuseid_2-s2.0-85054438887-
dc.identifier.hkuros301602-
dc.identifier.volume32-
dc.identifier.issue12-
dc.identifier.spage1100-
dc.identifier.epage1104-
dc.publisher.placeUnited States-

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