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- Publisher Website: 10.1146/annurev-biochem-013118-111754
- Scopus: eid_2-s2.0-85067809144
- PMID: 31018111
- WOS: WOS:000472818600024
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Article: Small-Molecule-Based Fluorescent Sensors for Selective Detection of Reactive Oxygen Species in Biological Systems
Title | Small-Molecule-Based Fluorescent Sensors for Selective Detection of Reactive Oxygen Species in Biological Systems |
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Authors | |
Keywords | chemical biology fluorescent sensor oxidative stressre active oxygen species redox biology |
Issue Date | 2019 |
Publisher | Annual Reviews. The Journal's web site is located at http://arjournals.annualreviews.org/loi/biochem |
Citation | Annual Review of Biochemistry, 2019, v. 88, p. 605-633 How to Cite? |
Abstract | Reactive oxygen species (ROS) encompass a collection of intricately linked chemical entities characterized by individually distinct physicochemical properties and biological reactivities. Although excessive ROS generation is well known to underpin disease development, it has become increasingly evident that ROS also play central roles in redox regulation and normal physiology. A major challenge in uncovering the relevant biological mechanisms and deconvoluting the apparently paradoxical roles of distinct ROS in human health and disease lies in the selective and sensitive detection of these transient species in the complex biological milieu. Small-molecule-based fluorescent sensors enable molecular imaging of ROS with great spatial and temporal resolution and have thus been appreciated as excellent tools for aiding discoveries in modern redox biology. We review a selection of state-of-the-art sensors with demonstrated utility in biological systems. By providing a systematic overview based on underlying chemical sensing mechanisms, we wish to highlight the strengths and weaknesses in prior sensor works and propose some guiding principles for the development of future probes. © 2019 by Annual Reviews. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/273839 |
ISSN | 2023 Impact Factor: 12.1 2023 SCImago Journal Rankings: 9.745 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bai, X | - |
dc.contributor.author | Ng, KHK | - |
dc.contributor.author | Hu, J | - |
dc.contributor.author | Ye, S | - |
dc.contributor.author | Yang, D | - |
dc.date.accessioned | 2019-08-18T14:49:36Z | - |
dc.date.available | 2019-08-18T14:49:36Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Annual Review of Biochemistry, 2019, v. 88, p. 605-633 | - |
dc.identifier.issn | 0066-4154 | - |
dc.identifier.uri | http://hdl.handle.net/10722/273839 | - |
dc.description.abstract | Reactive oxygen species (ROS) encompass a collection of intricately linked chemical entities characterized by individually distinct physicochemical properties and biological reactivities. Although excessive ROS generation is well known to underpin disease development, it has become increasingly evident that ROS also play central roles in redox regulation and normal physiology. A major challenge in uncovering the relevant biological mechanisms and deconvoluting the apparently paradoxical roles of distinct ROS in human health and disease lies in the selective and sensitive detection of these transient species in the complex biological milieu. Small-molecule-based fluorescent sensors enable molecular imaging of ROS with great spatial and temporal resolution and have thus been appreciated as excellent tools for aiding discoveries in modern redox biology. We review a selection of state-of-the-art sensors with demonstrated utility in biological systems. By providing a systematic overview based on underlying chemical sensing mechanisms, we wish to highlight the strengths and weaknesses in prior sensor works and propose some guiding principles for the development of future probes. © 2019 by Annual Reviews. All rights reserved. | - |
dc.language | eng | - |
dc.publisher | Annual Reviews. The Journal's web site is located at http://arjournals.annualreviews.org/loi/biochem | - |
dc.relation.ispartof | Annual Review of Biochemistry | - |
dc.subject | chemical biology | - |
dc.subject | fluorescent sensor | - |
dc.subject | oxidative stressre | - |
dc.subject | active oxygen species | - |
dc.subject | redox biology | - |
dc.title | Small-Molecule-Based Fluorescent Sensors for Selective Detection of Reactive Oxygen Species in Biological Systems | - |
dc.type | Article | - |
dc.identifier.email | Bai, X: xybai89@hku.hk | - |
dc.identifier.email | Ng, KHK: kkhn3@hku.hk | - |
dc.identifier.email | Ye, S: yesen@hku.hk | - |
dc.identifier.email | Yang, D: yangdan@hku.hk | - |
dc.identifier.authority | Ng, KHK=rp02424 | - |
dc.identifier.authority | Yang, D=rp00825 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1146/annurev-biochem-013118-111754 | - |
dc.identifier.pmid | 31018111 | - |
dc.identifier.scopus | eid_2-s2.0-85067809144 | - |
dc.identifier.hkuros | 301109 | - |
dc.identifier.volume | 88 | - |
dc.identifier.spage | 605 | - |
dc.identifier.epage | 633 | - |
dc.identifier.isi | WOS:000472818600024 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0066-4154 | - |