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Article: All-Aqueous Thin-film-flow-induced Cell-based Monolayers

TitleAll-Aqueous Thin-film-flow-induced Cell-based Monolayers
Authors
Keywordsall-aqueous system
assembly
dextran
poly(ethylene glycol) (PEG)
interfaces
Issue Date2019
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick
Citation
ACS Applied Materials & Interfaces, 2019, v. 11 n. 25, p. 22869-22877 How to Cite?
AbstractCells in vitro usually require a solid scaffold to attach and form two-dimensional monolayer structures. To obtain a substrate-free cell monolayer, long culture time and specific detaching procedures are required. In this study, a thin-film-flow-induced strategy is reported to overcome the challenges of assembling in vitro scaffold-free monolayered cell aggregates. The assembly is driven by a dewetting-like thin-film withdrawal along all-aqueous interfaces characterized by a low interfacial tension. The withdrawal process drives the cells adsorbed on the liquid film to aggregate and assemble into an organized and compact monolayer. This strategy is not limited to biological cells but also colloidal particles, as demonstrated by the assembly of hybrid cell–particle monolayers. The versatility offered by this approach suggests new opportunities in understanding early tissue formation and functionalizing cell monolayer aggregates by colloidal particles with customized functions.
Persistent Identifierhttp://hdl.handle.net/10722/273390
ISSN
2019 Impact Factor: 8.758
2015 SCImago Journal Rankings: 2.381

 

DC FieldValueLanguage
dc.contributor.authorChan, YK-
dc.contributor.authorYAN, WH-
dc.contributor.authorHUNG, LT-
dc.contributor.authorCHAO, Y-
dc.contributor.authorWU, J-
dc.contributor.authorShum, HC-
dc.date.accessioned2019-08-06T09:28:02Z-
dc.date.available2019-08-06T09:28:02Z-
dc.date.issued2019-
dc.identifier.citationACS Applied Materials & Interfaces, 2019, v. 11 n. 25, p. 22869-22877-
dc.identifier.issn1944-8244-
dc.identifier.urihttp://hdl.handle.net/10722/273390-
dc.description.abstractCells in vitro usually require a solid scaffold to attach and form two-dimensional monolayer structures. To obtain a substrate-free cell monolayer, long culture time and specific detaching procedures are required. In this study, a thin-film-flow-induced strategy is reported to overcome the challenges of assembling in vitro scaffold-free monolayered cell aggregates. The assembly is driven by a dewetting-like thin-film withdrawal along all-aqueous interfaces characterized by a low interfacial tension. The withdrawal process drives the cells adsorbed on the liquid film to aggregate and assemble into an organized and compact monolayer. This strategy is not limited to biological cells but also colloidal particles, as demonstrated by the assembly of hybrid cell–particle monolayers. The versatility offered by this approach suggests new opportunities in understanding early tissue formation and functionalizing cell monolayer aggregates by colloidal particles with customized functions.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick-
dc.relation.ispartofACS Applied Materials & Interfaces-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectall-aqueous system-
dc.subjectassembly-
dc.subjectdextran-
dc.subjectpoly(ethylene glycol) (PEG)-
dc.subjectinterfaces-
dc.titleAll-Aqueous Thin-film-flow-induced Cell-based Monolayers-
dc.typeArticle-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityChan, YK=rp02536-
dc.identifier.authorityShum, HC=rp01439-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsami.9b06382-
dc.identifier.pmid31145590-
dc.identifier.scopuseid_2-s2.0-85068146983-
dc.identifier.hkuros300872-
dc.identifier.volume11-
dc.identifier.issue25-
dc.identifier.spage22869-
dc.identifier.epage22877-
dc.publisher.placeUnited States-

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