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- Publisher Website: 10.1007/s00383-018-4393-3
- Scopus: eid_2-s2.0-85055972845
- PMID: 30386902
- WOS: WOS:000456316100003
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Article: Risk factors for the development of post-operative enterocolitis in short segment Hirschsprung’s disease
Title | Risk factors for the development of post-operative enterocolitis in short segment Hirschsprung’s disease |
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Authors | |
Keywords | Hirschsprung’s disease Enterocolitis Defunctioning stoma Dysbiosis |
Issue Date | 2019 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htm |
Citation | Pediatric Surgery International, 2019, v. 35 n. 2, p. 187-191 How to Cite? |
Abstract | Aim of the study:
The objective of this study is to identify risk factors associated with the development of post-operative enterocolitis (HAEC), in short segment Hirschsprung’s disease (HSCR-S).
Methods:
A retrospective study was carried out for post-operative patients with HSCR-S from 1997 to 2017. HSCR-S was defined as the most proximal extension of aganglionosis limited to the sigmoid colon. An episode of HAEC was defined as the presence of (1) vomiting or explosive diarrhea; (2) abdominal distension; (3) fever and (4) leukocytosis. Risk factors for the development of HACE were determined using multivariate logistic regression.
Main results:
The medical records of 96 patients were reviewed. The overall incidence of HAEC was 20.8% (n = 20) and 65.0% (n = 13) of HAEC occurred within the first year of operation. After a univariate logistic regression analysis, three risk factors for HAEC were identified: (1) presence of other major anomalies [OR: 1.43 (1.12–2.32), p = 0.041]; (2) creation of pre-operative defunctioning stoma [OR: 2.28 (1.47–3.23), p = 0.035]; (3) extension of aganglionosis to the sigmoid colon [OR: 1.89 (1.05–3.19), p = 0.049]. After multivariate logistic regression analysis, a significant association was demonstrated for creation of pre-operative defunctioning stoma [OR: 1.81 (1.08–3.22), p = 0.045] and extension of aganglionosis to the sigmoid colon [OR: 1.91 (1.37–2.98), p = 0.038].
Conclusions:
The requirement of pre-operative defunctioning stoma and a more proximal extension of aganglionosis are risk factors for the development of post-operative HAEC in HSCR-S. Patients with these risk factors should be closely followed up especially during the first year after the operation. |
Persistent Identifier | http://hdl.handle.net/10722/272977 |
ISSN | 2023 Impact Factor: 1.5 2023 SCImago Journal Rankings: 0.548 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chung, PHY | - |
dc.contributor.author | Yu, MON | - |
dc.contributor.author | Wong, KKY | - |
dc.contributor.author | Tam, PKH | - |
dc.date.accessioned | 2019-08-06T09:20:15Z | - |
dc.date.available | 2019-08-06T09:20:15Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Pediatric Surgery International, 2019, v. 35 n. 2, p. 187-191 | - |
dc.identifier.issn | 0179-0358 | - |
dc.identifier.uri | http://hdl.handle.net/10722/272977 | - |
dc.description.abstract | Aim of the study: The objective of this study is to identify risk factors associated with the development of post-operative enterocolitis (HAEC), in short segment Hirschsprung’s disease (HSCR-S). Methods: A retrospective study was carried out for post-operative patients with HSCR-S from 1997 to 2017. HSCR-S was defined as the most proximal extension of aganglionosis limited to the sigmoid colon. An episode of HAEC was defined as the presence of (1) vomiting or explosive diarrhea; (2) abdominal distension; (3) fever and (4) leukocytosis. Risk factors for the development of HACE were determined using multivariate logistic regression. Main results: The medical records of 96 patients were reviewed. The overall incidence of HAEC was 20.8% (n = 20) and 65.0% (n = 13) of HAEC occurred within the first year of operation. After a univariate logistic regression analysis, three risk factors for HAEC were identified: (1) presence of other major anomalies [OR: 1.43 (1.12–2.32), p = 0.041]; (2) creation of pre-operative defunctioning stoma [OR: 2.28 (1.47–3.23), p = 0.035]; (3) extension of aganglionosis to the sigmoid colon [OR: 1.89 (1.05–3.19), p = 0.049]. After multivariate logistic regression analysis, a significant association was demonstrated for creation of pre-operative defunctioning stoma [OR: 1.81 (1.08–3.22), p = 0.045] and extension of aganglionosis to the sigmoid colon [OR: 1.91 (1.37–2.98), p = 0.038]. Conclusions: The requirement of pre-operative defunctioning stoma and a more proximal extension of aganglionosis are risk factors for the development of post-operative HAEC in HSCR-S. Patients with these risk factors should be closely followed up especially during the first year after the operation. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00383/index.htm | - |
dc.relation.ispartof | Pediatric Surgery International | - |
dc.subject | Hirschsprung’s disease | - |
dc.subject | Enterocolitis | - |
dc.subject | Defunctioning stoma | - |
dc.subject | Dysbiosis | - |
dc.title | Risk factors for the development of post-operative enterocolitis in short segment Hirschsprung’s disease | - |
dc.type | Article | - |
dc.identifier.email | Chung, PHY: chungphy@hku.hk | - |
dc.identifier.email | Wong, KKY: kkywong@hku.hk | - |
dc.identifier.email | Tam, PKH: paultam@hku.hk | - |
dc.identifier.authority | Chung, PHY=rp02002 | - |
dc.identifier.authority | Wong, KKY=rp01392 | - |
dc.identifier.authority | Tam, PKH=rp00060 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00383-018-4393-3 | - |
dc.identifier.pmid | 30386902 | - |
dc.identifier.scopus | eid_2-s2.0-85055972845 | - |
dc.identifier.hkuros | 299598 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 187 | - |
dc.identifier.epage | 191 | - |
dc.identifier.isi | WOS:000456316100003 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0179-0358 | - |