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- Publisher Website: 10.1080/17460441.2019.1614559
- Scopus: eid_2-s2.0-85066884282
- PMID: 31111767
- WOS: WOS:000469703900001
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Article: Future challenges with DNA-encoded chemical libraries in the drug discovery domain
Title | Future challenges with DNA-encoded chemical libraries in the drug discovery domain |
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Authors | |
Keywords | DNA-encoded chemical library drug discovery high throughput screening combinatorial chemistry drug targets |
Issue Date | 2019 |
Publisher | Taylor & Francis. The Journal's web site is located at http://www.tandfonline.com/iedc |
Citation | Expert Opinion on Drug Discovery, 2019, v. 14 n. 8, p. 735-753 How to Cite? |
Abstract | Introduction: DNA-encoded chemical libraries (DELs) have come of age and emerged to become a powerful technology platform for ligand discovery in biomedical research and drug discovery. Today, DELs have been widely adopted in the pharmaceutical industry and employed in drug discovery programs worldwide. DELs are capable of interrogating drug targets with an extremely large number of compounds highly efficiently.
Area covered: In this review, the authors introduce the history of DELs and provide an overview of the major technological components, including encoding methods, library synthesis, chemistry, selection methods, hit deconvolution strategy, and post-selection data analysis. A brief update on the hit compounds recently discovered from DEL selections against drug targets is also provided. Finally, the authors discuss their views on the present challenges and future directions for the development and application of DELs in drug discovery.
Expert opinion: DELs have provided great opportunities for lead compound discovery at an unprecedented scale and efficiency in drug discovery. The key to the future success of DELs as true discovery modalities, rather than just ‘a way to make many compounds,’ is to go beyond physical binding to functional or even phenotypic assays with the capability to probe the biological system. |
Persistent Identifier | http://hdl.handle.net/10722/272848 |
ISSN | 2023 Impact Factor: 6.0 2023 SCImago Journal Rankings: 1.077 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhao, G | - |
dc.contributor.author | HUANG, Y | - |
dc.contributor.author | Zhou, Y | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Li, X | - |
dc.date.accessioned | 2019-08-06T09:17:43Z | - |
dc.date.available | 2019-08-06T09:17:43Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Expert Opinion on Drug Discovery, 2019, v. 14 n. 8, p. 735-753 | - |
dc.identifier.issn | 1746-0441 | - |
dc.identifier.uri | http://hdl.handle.net/10722/272848 | - |
dc.description.abstract | Introduction: DNA-encoded chemical libraries (DELs) have come of age and emerged to become a powerful technology platform for ligand discovery in biomedical research and drug discovery. Today, DELs have been widely adopted in the pharmaceutical industry and employed in drug discovery programs worldwide. DELs are capable of interrogating drug targets with an extremely large number of compounds highly efficiently. Area covered: In this review, the authors introduce the history of DELs and provide an overview of the major technological components, including encoding methods, library synthesis, chemistry, selection methods, hit deconvolution strategy, and post-selection data analysis. A brief update on the hit compounds recently discovered from DEL selections against drug targets is also provided. Finally, the authors discuss their views on the present challenges and future directions for the development and application of DELs in drug discovery. Expert opinion: DELs have provided great opportunities for lead compound discovery at an unprecedented scale and efficiency in drug discovery. The key to the future success of DELs as true discovery modalities, rather than just ‘a way to make many compounds,’ is to go beyond physical binding to functional or even phenotypic assays with the capability to probe the biological system. | - |
dc.language | eng | - |
dc.publisher | Taylor & Francis. The Journal's web site is located at http://www.tandfonline.com/iedc | - |
dc.relation.ispartof | Expert Opinion on Drug Discovery | - |
dc.rights | AOM/Preprint Before Accepted: his article has been accepted for publication in [JOURNAL TITLE], published by Taylor & Francis. AOM/Preprint After Accepted: This is an [original manuscript / preprint] of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI]. Accepted Manuscript (AM) i.e. Postprint This is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI]. | - |
dc.subject | DNA-encoded chemical library | - |
dc.subject | drug discovery | - |
dc.subject | high throughput screening | - |
dc.subject | combinatorial chemistry | - |
dc.subject | drug targets | - |
dc.title | Future challenges with DNA-encoded chemical libraries in the drug discovery domain | - |
dc.type | Article | - |
dc.identifier.email | Zhou, Y: yuchow@hku.hk | - |
dc.identifier.email | Li, X: xiaoyuli@hku.hk | - |
dc.identifier.authority | Li, X=rp02080 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1080/17460441.2019.1614559 | - |
dc.identifier.pmid | 31111767 | - |
dc.identifier.scopus | eid_2-s2.0-85066884282 | - |
dc.identifier.hkuros | 300874 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 735 | - |
dc.identifier.epage | 753 | - |
dc.identifier.isi | WOS:000469703900001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1746-0441 | - |