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Article: Effects of Maternal Voluntary Wheel Running During Pregnancy on Adult Hippocampal Neurogenesis, Temporal Order Memory, and Depression-Like Behavior in Adult Female and Male Offspring

TitleEffects of Maternal Voluntary Wheel Running During Pregnancy on Adult Hippocampal Neurogenesis, Temporal Order Memory, and Depression-Like Behavior in Adult Female and Male Offspring
Authors
KeywordsAdult neurogenesis
Depression-like behavior
Gender
Hippocampus
Maternal exercise
Issue Date2019
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience
Citation
Frontiers in Neuroscience, 2019, v. 13, p. article no. 470 How to Cite?
AbstractResearch suggests that maternal exercise in pregnancy may have beneficial effects on the brain function of offspring. This study sought to determine if voluntary wheel running during pregnancy improves depression-like behavior, temporal order memory, and hippocampal neurogenesis in both female and male offspring mice. Pregnant mice were allowed to run voluntarily by introducing running wheels into the housing cages throughout the gestational period. Male and female mice off spring at the age of 8-to 9-week-old were then tested on the temporal order task and forced swim test, then euthanized for immunostaining for examining adult hippocampal cell proliferation and neuronal differentiation. Results showed that both male and female pups had reduced depression-like behavior, while only male offspring demonstrated improvement in temporal order memory. Immunostaining revealed that male offspring showed an increase in the number of immature neurons in the ventral hippocampus, whereas female offspring showed enhanced cell proliferation in the dorsal hippocampus. These findings indicate that maternal voluntary wheel running benefits both female and male offspring on reducing depression-like behavior, but with gender effect on promoting hippocampal cell proliferation, neuronal differentiation, and temporal order memory. © 2019 Yau, Lee, Formolo, Lee, Li, Siu and Chan.
Persistent Identifierhttp://hdl.handle.net/10722/272676
ISSN
2017 Impact Factor: 3.877

 

DC FieldValueLanguage
dc.contributor.authorYAU, SY-
dc.contributor.authorLEE, THY-
dc.contributor.authorFormolo, DA-
dc.contributor.authorLEE, WL-
dc.contributor.authorLI, LCK-
dc.contributor.authorSiu, PM-
dc.contributor.authorCHAN, CCH-
dc.date.accessioned2019-08-06T09:14:27Z-
dc.date.available2019-08-06T09:14:27Z-
dc.date.issued2019-
dc.identifier.citationFrontiers in Neuroscience, 2019, v. 13, p. article no. 470-
dc.identifier.issn1662-453X-
dc.identifier.urihttp://hdl.handle.net/10722/272676-
dc.description.abstractResearch suggests that maternal exercise in pregnancy may have beneficial effects on the brain function of offspring. This study sought to determine if voluntary wheel running during pregnancy improves depression-like behavior, temporal order memory, and hippocampal neurogenesis in both female and male offspring mice. Pregnant mice were allowed to run voluntarily by introducing running wheels into the housing cages throughout the gestational period. Male and female mice off spring at the age of 8-to 9-week-old were then tested on the temporal order task and forced swim test, then euthanized for immunostaining for examining adult hippocampal cell proliferation and neuronal differentiation. Results showed that both male and female pups had reduced depression-like behavior, while only male offspring demonstrated improvement in temporal order memory. Immunostaining revealed that male offspring showed an increase in the number of immature neurons in the ventral hippocampus, whereas female offspring showed enhanced cell proliferation in the dorsal hippocampus. These findings indicate that maternal voluntary wheel running benefits both female and male offspring on reducing depression-like behavior, but with gender effect on promoting hippocampal cell proliferation, neuronal differentiation, and temporal order memory. © 2019 Yau, Lee, Formolo, Lee, Li, Siu and Chan.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience-
dc.relation.ispartofFrontiers in Neuroscience-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAdult neurogenesis-
dc.subjectDepression-like behavior-
dc.subjectGender-
dc.subjectHippocampus-
dc.subjectMaternal exercise-
dc.titleEffects of Maternal Voluntary Wheel Running During Pregnancy on Adult Hippocampal Neurogenesis, Temporal Order Memory, and Depression-Like Behavior in Adult Female and Male Offspring-
dc.typeArticle-
dc.identifier.emailSiu, PM: pmsiu@hku.hk-
dc.identifier.authoritySiu, PM=rp02292-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fnins.2019.00470-
dc.identifier.scopuseid_2-s2.0-85068571939-
dc.identifier.hkuros299834-
dc.identifier.volume13-
dc.identifier.spagearticle no. 470-
dc.identifier.epagearticle no. 470-
dc.publisher.placeSwitzerland-

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