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Article: Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes

TitlePeriodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes
Authors
KeywordsDiabetes mellitus
Echocardiography
Left ventricular dysfunction
Periodontitis
Issue Date2019
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
Citation
Journal of Periodontal Research, 2019, v. 54 n. 4, p. 339-348 How to Cite?
AbstractBackground and Objective: Subjects with diabetes and periodontitis are at high risk of cardiovascular events, while the subclinical alterations of cardiac function in this cohort remain unclear. This cross‐sectional study investigated the association of periodontitis with left ventricle (LV) structural and functional abnormalities in subjects with type 2 diabetes mellitus (T2DM). Material and Methods: A total of 115 subjects with T2DM were divided into Control group (n = 32) with no or mild periodontitis, and the rest with moderate to severe chronic periodontitis (CP) were further categorized into CP‐1 (n = 41) and CP‐2 (n = 42) based on disease severity. Echocardiography was performed to precisely assess (a) LV hypertrophy by LV mass index (LVMi); (b) LV diastolic function by tissue Doppler imaging index E/e’ ratio; and (c) LV systolic function by speckle tracking derived global longitudinal strain (GLS). Results: Overall, a linear trend in LVMi, E/e’, and GLS existed among the Control, CP‐1, and CP‐2 groups, respectively (P < 0.05). After adjustments of multiple confounders, CP‐2 subjects showed significantly higher E/e’ (log scale, 2.22 ± 0.05 vs 2.07 ± 0.06, P < 0.01) and GLS (−17.42 ± 0.46% vs −18.95 ± 0.54%, P < 0.05) than the Controls. Multivariate analysis revealed that sites% with probing depth ≥4 mm and sites% with clinical attachment loss ≥5 mm were independent indicators for E/e’ (β = 0.005 and β = 0.002, P < 0.01) and GLS (β = 0.03 and β = 0.02, P < 0.05) , respectively. Moreover, the number of missing teeth was significantly associated with LVMi (β = 0.01, P < 0.01). Conclusion: This study provides the first evidence that severe periodontitis is significantly associated with the exacerbation of LV diastolic and systolic dysfunction in subjects with T2DM.
Persistent Identifierhttp://hdl.handle.net/10722/272133
ISSN
2017 Impact Factor: 2.878
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Y-
dc.contributor.authorZhen, Z-
dc.contributor.authorLiu, HN-
dc.contributor.authorLai, I-
dc.contributor.authorPelekos, G-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.contributor.authorJin, L-
dc.date.accessioned2019-07-20T10:36:18Z-
dc.date.available2019-07-20T10:36:18Z-
dc.date.issued2019-
dc.identifier.citationJournal of Periodontal Research, 2019, v. 54 n. 4, p. 339-348-
dc.identifier.issn0022-3484-
dc.identifier.urihttp://hdl.handle.net/10722/272133-
dc.description.abstractBackground and Objective: Subjects with diabetes and periodontitis are at high risk of cardiovascular events, while the subclinical alterations of cardiac function in this cohort remain unclear. This cross‐sectional study investigated the association of periodontitis with left ventricle (LV) structural and functional abnormalities in subjects with type 2 diabetes mellitus (T2DM). Material and Methods: A total of 115 subjects with T2DM were divided into Control group (n = 32) with no or mild periodontitis, and the rest with moderate to severe chronic periodontitis (CP) were further categorized into CP‐1 (n = 41) and CP‐2 (n = 42) based on disease severity. Echocardiography was performed to precisely assess (a) LV hypertrophy by LV mass index (LVMi); (b) LV diastolic function by tissue Doppler imaging index E/e’ ratio; and (c) LV systolic function by speckle tracking derived global longitudinal strain (GLS). Results: Overall, a linear trend in LVMi, E/e’, and GLS existed among the Control, CP‐1, and CP‐2 groups, respectively (P < 0.05). After adjustments of multiple confounders, CP‐2 subjects showed significantly higher E/e’ (log scale, 2.22 ± 0.05 vs 2.07 ± 0.06, P < 0.01) and GLS (−17.42 ± 0.46% vs −18.95 ± 0.54%, P < 0.05) than the Controls. Multivariate analysis revealed that sites% with probing depth ≥4 mm and sites% with clinical attachment loss ≥5 mm were independent indicators for E/e’ (β = 0.005 and β = 0.002, P < 0.01) and GLS (β = 0.03 and β = 0.02, P < 0.05) , respectively. Moreover, the number of missing teeth was significantly associated with LVMi (β = 0.01, P < 0.01). Conclusion: This study provides the first evidence that severe periodontitis is significantly associated with the exacerbation of LV diastolic and systolic dysfunction in subjects with T2DM.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1-
dc.relation.ispartofJournal of Periodontal Research-
dc.subjectDiabetes mellitus-
dc.subjectEchocardiography-
dc.subjectLeft ventricular dysfunction-
dc.subjectPeriodontitis-
dc.titlePeriodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes-
dc.typeArticle-
dc.identifier.emailLiu, HN: drdhnl@hku.hk-
dc.identifier.emailLai, I: drianlai@hku.hk-
dc.identifier.emailPelekos, G: george74@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.authorityPelekos, G=rp01894-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.authorityJin, L=rp00028-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jre.12634-
dc.identifier.pmid30635912-
dc.identifier.scopuseid_2-s2.0-85059889987-
dc.identifier.hkuros299272-
dc.identifier.volume54-
dc.identifier.issue4-
dc.identifier.spage339-
dc.identifier.epage348-
dc.identifier.isiWOS:000475473300004-
dc.publisher.placeUnited States-

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