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Article: Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018

TitleDonor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018
Authors
Keywordsacute hepatitis
adult
bronchiectasis
case report
chronic obstructive lung disease
Issue Date2019
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2019, v. 25 n. 3, p. 425-433 How to Cite?
AbstractHepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients.
Persistent Identifierhttp://hdl.handle.net/10722/272101
ISSN
2019 Impact Factor: 6.259
2015 SCImago Journal Rankings: 3.023
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorSridhar, S-
dc.contributor.authorCheng, VCC-
dc.contributor.authorWong, SC-
dc.contributor.authorYip, CY-
dc.contributor.authorWu, S-
dc.contributor.authorLo, AWI-
dc.contributor.authorLeung, KH-
dc.contributor.authorMak, WWN-
dc.contributor.authorCai, J-
dc.contributor.authorLi, X-
dc.contributor.authorChan, JF-
dc.contributor.authorLau, SKP-
dc.contributor.authorWoo, PCY-
dc.contributor.authorLai, WM-
dc.contributor.authorKwan, TH-
dc.contributor.authorAu, TWK-
dc.contributor.authorLo, CM-
dc.contributor.authorWong, SCY-
dc.contributor.authorYuen, KY-
dc.date.accessioned2019-07-20T10:35:42Z-
dc.date.available2019-07-20T10:35:42Z-
dc.date.issued2019-
dc.identifier.citationEmerging Infectious Diseases, 2019, v. 25 n. 3, p. 425-433-
dc.identifier.issn1080-6040-
dc.identifier.urihttp://hdl.handle.net/10722/272101-
dc.description.abstractHepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients.-
dc.languageeng-
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm-
dc.relation.ispartofEmerging Infectious Diseases-
dc.subjectacute hepatitis-
dc.subjectadult-
dc.subjectbronchiectasis-
dc.subjectcase report-
dc.subjectchronic obstructive lung disease-
dc.titleDonor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018-
dc.typeArticle-
dc.identifier.emailSridhar, S: sid8998@hku.hk-
dc.identifier.emailCheng, VCC: vcccheng@hkucc.hku.hk-
dc.identifier.emailWong, SC: shchwong@hku.hk-
dc.identifier.emailYip, CY: yipcyril@hku.hk-
dc.identifier.emailWu, S: wss2017@hku.hk-
dc.identifier.emailLeung, KH: khl17@hku.hk-
dc.identifier.emailCai, J: caijuice@hku.hk-
dc.identifier.emailLi, X: xinbaby@hku.hk-
dc.identifier.emailChan, JF: jfwchan@hku.hk-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailWong, SCY: wcy288@HKUCC-COM.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authoritySridhar, S=rp02249-
dc.identifier.authorityYip, CY=rp01721-
dc.identifier.authorityChan, JF=rp01736-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityWoo, PCY=rp00430-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3201/eid2503.181563-
dc.identifier.pmid30789146-
dc.identifier.pmcidPMC6390757-
dc.identifier.scopuseid_2-s2.0-85061982611-
dc.identifier.hkuros298348-
dc.identifier.volume25-
dc.identifier.issue3-
dc.identifier.spage425-
dc.identifier.epage433-
dc.publisher.placeUnited States-

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