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Article: Epstein-Barr virus-coded miR-BART13 promotes nasopharyngeal carcinoma cell growth and metastasis via targeting of the NKIRAS2/NF-κB pathway

TitleEpstein-Barr virus-coded miR-BART13 promotes nasopharyngeal carcinoma cell growth and metastasis via targeting of the NKIRAS2/NF-κB pathway
Authors
KeywordsNasopharyngeal carcinoma
miR-BART13
NKIRAS2
Cell growth
Metastasis
Issue Date2019
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2019, v. 447, p. 33-40 How to Cite?
AbstractBased on analysis of Epstein-Barr virus (EBV) BART microRNA expression profiles, we previously reported that EBV-encoded miR-BART13 is upregulated in nasopharyngeal carcinoma (NPC) plasma specimens. However, the effects and molecular mechanisms of miR-BART13 in NPC remain largely unknown. We found that miR-BART13 was significantly upregulated in NPC tissue specimens. Ectopic expression of miR-BART13 promoted NPC cell proliferation, epithelial mesenchymal transition, and metastasis in vitro, and facilitated xenograft tumor growth and lung metastasis in vivo. Molecularly, NF-κB inhibitor interacting Ras-like 2 (NKIRAS2), a negative regulator of the NF-κB signaling, was identified to be a direct target of miR-BART13 in NPC cells, and NKIRAS2 mRNA and protein expression was inversely correlated with miR-BART13 in NPC tissues, respecitvely. Furthermore, the NF-κB signaling pathway was activated by miR-BART13. By rescued experiments, reconstitution of NKIRAS2 expression abrogated all the phenotypes upregulated by miR-BART13, and attenuated activity of NF-κB signaling pathway activated by miR-BART13 in NPC cells. Our findings indicated the newly identified miR-BART13/NKIRAS2/NF-κB signaling axis may provide further insights into better understanding of NPC initiation and development, and targeting of this pathway could be further studied as a therapeutic strategy for NPC patients.
Persistent Identifierhttp://hdl.handle.net/10722/272052
ISSN
2017 Impact Factor: 6.491
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, YJ-
dc.contributor.authorZhou, R-
dc.contributor.authorZong, JF-
dc.contributor.authorLin, WS-
dc.contributor.authorTong, S-
dc.contributor.authorGuo, QJ-
dc.contributor.authorLin, C-
dc.contributor.authorLin, SJ-
dc.contributor.authorChen, YX-
dc.contributor.authorChen, MR-
dc.contributor.authorChen, H-
dc.contributor.authorYe, YB-
dc.contributor.authorPan, JJ-
dc.date.accessioned2019-07-20T10:34:43Z-
dc.date.available2019-07-20T10:34:43Z-
dc.date.issued2019-
dc.identifier.citationCancer Letters, 2019, v. 447, p. 33-40-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10722/272052-
dc.description.abstractBased on analysis of Epstein-Barr virus (EBV) BART microRNA expression profiles, we previously reported that EBV-encoded miR-BART13 is upregulated in nasopharyngeal carcinoma (NPC) plasma specimens. However, the effects and molecular mechanisms of miR-BART13 in NPC remain largely unknown. We found that miR-BART13 was significantly upregulated in NPC tissue specimens. Ectopic expression of miR-BART13 promoted NPC cell proliferation, epithelial mesenchymal transition, and metastasis in vitro, and facilitated xenograft tumor growth and lung metastasis in vivo. Molecularly, NF-κB inhibitor interacting Ras-like 2 (NKIRAS2), a negative regulator of the NF-κB signaling, was identified to be a direct target of miR-BART13 in NPC cells, and NKIRAS2 mRNA and protein expression was inversely correlated with miR-BART13 in NPC tissues, respecitvely. Furthermore, the NF-κB signaling pathway was activated by miR-BART13. By rescued experiments, reconstitution of NKIRAS2 expression abrogated all the phenotypes upregulated by miR-BART13, and attenuated activity of NF-κB signaling pathway activated by miR-BART13 in NPC cells. Our findings indicated the newly identified miR-BART13/NKIRAS2/NF-κB signaling axis may provide further insights into better understanding of NPC initiation and development, and targeting of this pathway could be further studied as a therapeutic strategy for NPC patients.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet-
dc.relation.ispartofCancer Letters-
dc.subjectNasopharyngeal carcinoma-
dc.subjectmiR-BART13-
dc.subjectNKIRAS2-
dc.subjectCell growth-
dc.subjectMetastasis-
dc.titleEpstein-Barr virus-coded miR-BART13 promotes nasopharyngeal carcinoma cell growth and metastasis via targeting of the NKIRAS2/NF-κB pathway-
dc.typeArticle-
dc.identifier.emailChen, H: hlchen@hku.hk-
dc.identifier.authorityChen, H=rp00383-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2019.01.022-
dc.identifier.pmid30684592-
dc.identifier.scopuseid_2-s2.0-85060544670-
dc.identifier.hkuros298564-
dc.identifier.volume447-
dc.identifier.spage33-
dc.identifier.epage40-
dc.identifier.isiWOS:000460711900004-
dc.publisher.placeIreland-

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