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- Publisher Website: 10.1039/C8NR08498J
- Scopus: eid_2-s2.0-85060372255
- PMID: 30623943
- WOS: WOS:000459910900019
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Article: Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy
Title | Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy |
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Authors | |
Keywords | Amino acids Ammonia Carbon dioxide Cavitation Cell death |
Issue Date | 2018 |
Publisher | RSC Publications. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/nr#!recentarticles&all |
Citation | Nanoscale, 2018, v. 11 n. 4, p. 1710-1719 How to Cite? |
Abstract | Microwave irradiation is a powerful non-invasive approach for treating deep-seated diseases in a clinical setting. Pulsed microwave-induced thermoacoustic cavitation allows precise cancer treatment with microwave-absorbing materials. This differs from the traditional continuous microwave-induced thermotherapy which may be harmful to off-target tissues. Here we first report the integration of thermocavitation and cytoplasmic drug release into highly explosible cell-penetrating nanocapsules for effective tumor inhibition under pulsed microwave irradiation. The nanocapsules were formulated from arginine-tethered reduction-responsive copolymers, P(ArgMA-co-DMA)-b-PPOPMA, microwave-absorbing AB and chemotherapeutic DOX using a double-emulsion method. The nanocapsules were internalized by cancer cells rapidly via major energy-independent pathways. Upon pulsed microwave irradiation, AB absorbed energy to generate a giant thermoacoustic shockwave, simultaneously decomposing into carbon dioxide and ammonia which enforced the cavitation damage effect. The thermoacoustic shockwave and gas burst also mechanically disrupted the intracellular organelles resulting in high-ratio cell necrosis and promoted the cytosolic release of DOX into the nucleus to initiate cell death. Importantly, in vivo results demonstrated significantly suppressed tumor growth by the pulsed microwave-triggered thermocavitation and drug release, and minimal systemic toxicity from the microwave treatment. Therefore, our study provides a new strategy for effectively engineering pulsed microwave-responsive nanomaterials for smart cancer therapy. |
Persistent Identifier | http://hdl.handle.net/10722/271936 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 1.416 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Z | - |
dc.contributor.author | ZHANG, Y | - |
dc.contributor.author | Cao, B | - |
dc.contributor.author | Ji, Z | - |
dc.contributor.author | Luo, W | - |
dc.contributor.author | Zhai, S | - |
dc.contributor.author | Zhang, D | - |
dc.contributor.author | Wang, W | - |
dc.contributor.author | Xing, D | - |
dc.contributor.author | Hu, X | - |
dc.date.accessioned | 2019-07-20T10:32:25Z | - |
dc.date.available | 2019-07-20T10:32:25Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Nanoscale, 2018, v. 11 n. 4, p. 1710-1719 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | http://hdl.handle.net/10722/271936 | - |
dc.description.abstract | Microwave irradiation is a powerful non-invasive approach for treating deep-seated diseases in a clinical setting. Pulsed microwave-induced thermoacoustic cavitation allows precise cancer treatment with microwave-absorbing materials. This differs from the traditional continuous microwave-induced thermotherapy which may be harmful to off-target tissues. Here we first report the integration of thermocavitation and cytoplasmic drug release into highly explosible cell-penetrating nanocapsules for effective tumor inhibition under pulsed microwave irradiation. The nanocapsules were formulated from arginine-tethered reduction-responsive copolymers, P(ArgMA-co-DMA)-b-PPOPMA, microwave-absorbing AB and chemotherapeutic DOX using a double-emulsion method. The nanocapsules were internalized by cancer cells rapidly via major energy-independent pathways. Upon pulsed microwave irradiation, AB absorbed energy to generate a giant thermoacoustic shockwave, simultaneously decomposing into carbon dioxide and ammonia which enforced the cavitation damage effect. The thermoacoustic shockwave and gas burst also mechanically disrupted the intracellular organelles resulting in high-ratio cell necrosis and promoted the cytosolic release of DOX into the nucleus to initiate cell death. Importantly, in vivo results demonstrated significantly suppressed tumor growth by the pulsed microwave-triggered thermocavitation and drug release, and minimal systemic toxicity from the microwave treatment. Therefore, our study provides a new strategy for effectively engineering pulsed microwave-responsive nanomaterials for smart cancer therapy. | - |
dc.language | eng | - |
dc.publisher | RSC Publications. The Journal's web site is located at http://pubs.rsc.org/en/journals/journalissues/nr#!recentarticles&all | - |
dc.relation.ispartof | Nanoscale | - |
dc.subject | Amino acids | - |
dc.subject | Ammonia | - |
dc.subject | Carbon dioxide | - |
dc.subject | Cavitation | - |
dc.subject | Cell death | - |
dc.title | Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy | - |
dc.type | Article | - |
dc.identifier.email | Wang, W: wangwp@hku.hk | - |
dc.identifier.authority | Wang, W=rp02227 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/C8NR08498J | - |
dc.identifier.pmid | 30623943 | - |
dc.identifier.scopus | eid_2-s2.0-85060372255 | - |
dc.identifier.hkuros | 298813 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1710 | - |
dc.identifier.epage | 1719 | - |
dc.identifier.isi | WOS:000459910900019 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2040-3364 | - |