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Article: Lung cancer risk by geologic coal deposits: a case–control study of female never‐smokers from Xuanwei and Fuyuan, China

TitleLung cancer risk by geologic coal deposits: a case–control study of female never‐smokers from Xuanwei and Fuyuan, China
Authors
Keywordsbituminous “smoky” coal
geographic variation
geologic coal deposit
indoor air pollution
lung cancer
Issue Date2019
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal of Cancer, 2019, v. 144 n. 12, p. 2918-2927 How to Cite?
AbstractCoal types vary around the world because of geochemical differences in their source deposits; however, the influence of coal emissions from different deposits on human health remains unexplored. To address this issue, we conducted the first study of the relationship between coal use from various deposits and lung cancer risk in Xuanwei and Fuyuan, counties in China where lung cancer rates are among the highest in the world among female never‐smokers due to use of bituminous (“smoky”) coal for heating and cooking. We conducted a population‐based case–control study of 1031 lung cancer cases and 493 controls among never‐smoking women in Xuanwei and Fuyuan. Logistic regression models were used to estimate associations between coal use from various deposits across the lifecourse and lung cancer risk. There was substantial heterogeneity in risks by coal deposit (p = 7.8E‐05). Compared to non‐smoky coal users, risks by smoky coal deposit ranged from OR = 7.49 (95% CI: 3.43–16.38) to OR = 33.40 (95% CI: 13.07–85.34). Further, women born into homes that used smoky coal and subsequently changed to non‐smoky coal had a higher risk (OR = 10.83 (95% CI: 4.61–25.46)) than women born into homes that used non‐smoky coal and changed to smoky coal (OR = 4.74 (95% CI: 2.03–11.04, pdifference = 0.04)). Our study demonstrates that various sources of coal have considerably different impact on lung cancer in this population and suggests that early‐life exposure to carcinogenic emissions may exert substantial influence on health risks later in life. These factors should be considered when evaluating the health risks posed by exposure to coal combustion emissions.
Persistent Identifierhttp://hdl.handle.net/10722/271177
ISSN
2017 Impact Factor: 7.36
2015 SCImago Journal Rankings: 2.657

 

DC FieldValueLanguage
dc.contributor.authorWong, JYY-
dc.contributor.authorDownward, GS-
dc.contributor.authorHu, W-
dc.contributor.authorPortengen, L-
dc.contributor.authorSeow, WJ-
dc.contributor.authorSilverman, DT-
dc.contributor.authorBassig, BA-
dc.contributor.authorZhang, J-
dc.contributor.authorXu, J-
dc.contributor.authorJi, BT-
dc.contributor.authorLi, J-
dc.contributor.authorHe, J-
dc.contributor.authorYang, K-
dc.contributor.authorTian, L-
dc.contributor.authorShen, M-
dc.contributor.authorHuang, Y-
dc.contributor.authorVermeulen, R-
dc.contributor.authorRothman, N-
dc.contributor.authorLan, Q-
dc.date.accessioned2019-06-24T01:04:49Z-
dc.date.available2019-06-24T01:04:49Z-
dc.date.issued2019-
dc.identifier.citationInternational Journal of Cancer, 2019, v. 144 n. 12, p. 2918-2927-
dc.identifier.issn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10722/271177-
dc.description.abstractCoal types vary around the world because of geochemical differences in their source deposits; however, the influence of coal emissions from different deposits on human health remains unexplored. To address this issue, we conducted the first study of the relationship between coal use from various deposits and lung cancer risk in Xuanwei and Fuyuan, counties in China where lung cancer rates are among the highest in the world among female never‐smokers due to use of bituminous (“smoky”) coal for heating and cooking. We conducted a population‐based case–control study of 1031 lung cancer cases and 493 controls among never‐smoking women in Xuanwei and Fuyuan. Logistic regression models were used to estimate associations between coal use from various deposits across the lifecourse and lung cancer risk. There was substantial heterogeneity in risks by coal deposit (p = 7.8E‐05). Compared to non‐smoky coal users, risks by smoky coal deposit ranged from OR = 7.49 (95% CI: 3.43–16.38) to OR = 33.40 (95% CI: 13.07–85.34). Further, women born into homes that used smoky coal and subsequently changed to non‐smoky coal had a higher risk (OR = 10.83 (95% CI: 4.61–25.46)) than women born into homes that used non‐smoky coal and changed to smoky coal (OR = 4.74 (95% CI: 2.03–11.04, pdifference = 0.04)). Our study demonstrates that various sources of coal have considerably different impact on lung cancer in this population and suggests that early‐life exposure to carcinogenic emissions may exert substantial influence on health risks later in life. These factors should be considered when evaluating the health risks posed by exposure to coal combustion emissions.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home-
dc.relation.ispartofInternational Journal of Cancer-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectbituminous “smoky” coal-
dc.subjectgeographic variation-
dc.subjectgeologic coal deposit-
dc.subjectindoor air pollution-
dc.subjectlung cancer-
dc.titleLung cancer risk by geologic coal deposits: a case–control study of female never‐smokers from Xuanwei and Fuyuan, China-
dc.typeArticle-
dc.identifier.emailXu, J: xusunjun@hku.hk-
dc.identifier.emailTian, L: linweit@hku.hk-
dc.identifier.authorityTian, L=rp01991-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ijc.32034-
dc.identifier.pmid30511435-
dc.identifier.hkuros298210-
dc.identifier.volume144-
dc.identifier.issue12-
dc.identifier.spage2918-
dc.identifier.epage2927-
dc.publisher.placeUnited States-

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