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Article: Bituminous coal combustion and Xuan Wei Lung cancer: a review of the epidemiology, intervention, carcinogens, and carcinogenesis

TitleBituminous coal combustion and Xuan Wei Lung cancer: a review of the epidemiology, intervention, carcinogens, and carcinogenesis
Authors
KeywordsXuan Wei
Lung cancer
Bituminous coal smoke
Particulate matter
Issue Date2019
PublisherSpringer for German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT). The Journal's web site is located at http://link.springer.de/link/service/journals/00204/index.htm
Citation
Archives of Toxicology, 2019, v. 93 n. 3, p. 573-583 How to Cite?
AbstractIndoor air pollution from bituminous coal combustion has been linked to the extremely high lung cancer rates of nonsmoking women in Xuan Wei County, Yunnan Province, China. Venting the smoke outdoors by installing chimneys was found to be effective at reducing the lung cancer risk in a cohort study of 21,232 farmers in central Xuan Wei. However, the lung cancer mortality rates in all 1.2 million residents of Xuan Wei have been increasing dramatically over the last four decades. It was higher than that in Yunnan Province and China overall, with significant heterogeneities in the geographic patterns of Xuan Wei. Intervention measures targeting certain types of coal or certain carcinogenic components in coal smoke need to be explored. To inform targeted intervention policies, it is essential to pinpoint the specific substance (particulate matter, organic extract, PAHs, free radicals, crystalline silica, and inorganic matter) that might account for the carcinogenicity of bituminous coal smoke. Exploring the underlying carcinogenesis mechanisms would also contribute to the intervention and control of the lung cancer epidemic in Xuan Wei, China. Here we review the suspected carcinogens and carcinogenesis mechanisms and discuss future research directions towards a better understanding of the etiology of lung cancer in Xuan Wei, China.
Persistent Identifierhttp://hdl.handle.net/10722/271175
ISSN
2017 Impact Factor: 5.728
2015 SCImago Journal Rankings: 1.595

 

DC FieldValueLanguage
dc.contributor.authorLI, J-
dc.contributor.authorRAN, J-
dc.contributor.authorChen, LC-
dc.contributor.authorCosta, M-
dc.contributor.authorHuang, Y-
dc.contributor.authorChen, X-
dc.contributor.authorTian, L-
dc.date.accessioned2019-06-24T01:04:47Z-
dc.date.available2019-06-24T01:04:47Z-
dc.date.issued2019-
dc.identifier.citationArchives of Toxicology, 2019, v. 93 n. 3, p. 573-583-
dc.identifier.issn0340-5761-
dc.identifier.urihttp://hdl.handle.net/10722/271175-
dc.description.abstractIndoor air pollution from bituminous coal combustion has been linked to the extremely high lung cancer rates of nonsmoking women in Xuan Wei County, Yunnan Province, China. Venting the smoke outdoors by installing chimneys was found to be effective at reducing the lung cancer risk in a cohort study of 21,232 farmers in central Xuan Wei. However, the lung cancer mortality rates in all 1.2 million residents of Xuan Wei have been increasing dramatically over the last four decades. It was higher than that in Yunnan Province and China overall, with significant heterogeneities in the geographic patterns of Xuan Wei. Intervention measures targeting certain types of coal or certain carcinogenic components in coal smoke need to be explored. To inform targeted intervention policies, it is essential to pinpoint the specific substance (particulate matter, organic extract, PAHs, free radicals, crystalline silica, and inorganic matter) that might account for the carcinogenicity of bituminous coal smoke. Exploring the underlying carcinogenesis mechanisms would also contribute to the intervention and control of the lung cancer epidemic in Xuan Wei, China. Here we review the suspected carcinogens and carcinogenesis mechanisms and discuss future research directions towards a better understanding of the etiology of lung cancer in Xuan Wei, China.-
dc.languageeng-
dc.publisherSpringer for German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT). The Journal's web site is located at http://link.springer.de/link/service/journals/00204/index.htm-
dc.relation.ispartofArchives of Toxicology-
dc.subjectXuan Wei-
dc.subjectLung cancer-
dc.subjectBituminous coal smoke-
dc.subjectParticulate matter-
dc.titleBituminous coal combustion and Xuan Wei Lung cancer: a review of the epidemiology, intervention, carcinogens, and carcinogenesis-
dc.typeArticle-
dc.identifier.emailTian, L: linweit@hku.hk-
dc.identifier.authorityTian, L=rp01991-
dc.identifier.doi10.1007/s00204-019-02392-y-
dc.identifier.pmid30649585-
dc.identifier.scopuseid_2-s2.0-85060182400-
dc.identifier.hkuros298212-
dc.identifier.volume93-
dc.identifier.issue3-
dc.identifier.spage573-
dc.identifier.epage583-
dc.publisher.placeGermany-

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