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Article: Peptide-based Approaches To Identify And Characterize Proteins That Recognize Histone Post-translational Modifications

TitlePeptide-based Approaches To Identify And Characterize Proteins That Recognize Histone Post-translational Modifications
Authors
Issue Date2018
PublisherElsevier Ltd for Chinese Chemical Society. The Journal's web site is located at http://www.chinchemlett.com.cn
Citation
Chinese Chemical Letters, 2018, v. 29, p. 1051-1057 How to Cite?
AbstractIncreasing amount of evidence suggests that post-translational modifications (PTMs) on histones are involved in regulating DNA-associated processes such as gene expression and DNA-damage repair. To identify and characterize proteins that recognize histone PTMs, tools relying on synthetic peptides have been constructed and widely used in recent years. In this review, we first summarize the development and applications of these tools, which includes peptide-based pull-down assay and peptide-array-based high-throughput screening. The limitation of peptide-based approaches is then discussed, followed by a brief description on recent development of nucleosome-based tools.
Persistent Identifierhttp://hdl.handle.net/10722/269417
ISSN
2017 Impact Factor: 2.631
2015 SCImago Journal Rankings: 0.451

 

DC FieldValueLanguage
dc.contributor.authorLIN, J-
dc.contributor.authorLi, XD-
dc.date.accessioned2019-04-24T08:07:17Z-
dc.date.available2019-04-24T08:07:17Z-
dc.date.issued2018-
dc.identifier.citationChinese Chemical Letters, 2018, v. 29, p. 1051-1057-
dc.identifier.issn1001-8417-
dc.identifier.urihttp://hdl.handle.net/10722/269417-
dc.description.abstractIncreasing amount of evidence suggests that post-translational modifications (PTMs) on histones are involved in regulating DNA-associated processes such as gene expression and DNA-damage repair. To identify and characterize proteins that recognize histone PTMs, tools relying on synthetic peptides have been constructed and widely used in recent years. In this review, we first summarize the development and applications of these tools, which includes peptide-based pull-down assay and peptide-array-based high-throughput screening. The limitation of peptide-based approaches is then discussed, followed by a brief description on recent development of nucleosome-based tools.-
dc.languageeng-
dc.publisherElsevier Ltd for Chinese Chemical Society. The Journal's web site is located at http://www.chinchemlett.com.cn-
dc.relation.ispartofChinese Chemical Letters-
dc.titlePeptide-based Approaches To Identify And Characterize Proteins That Recognize Histone Post-translational Modifications-
dc.typeArticle-
dc.identifier.emailLi, XD: xiangli@hku.hk-
dc.identifier.authorityLi, XD=rp01562-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cclet.2018.05.017-
dc.identifier.hkuros297531-
dc.identifier.volume29-
dc.identifier.spage1051-
dc.identifier.epage1057-
dc.publisher.placeChina-

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