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Article: Peptide-based Approaches To Identify And Characterize Proteins That Recognize Histone Post-translational Modifications

TitlePeptide-based Approaches To Identify And Characterize Proteins That Recognize Histone Post-translational Modifications
Authors
KeywordsCrosslinkers
Histone PTMs
Peptide libraries
Peptide microarrays
Peptide pull-down
Issue Date2018
PublisherElsevier Ltd for Chinese Chemical Society. The Journal's web site is located at http://www.chinchemlett.com.cn
Citation
Chinese Chemical Letters, 2018, v. 29, p. 1051-1057 How to Cite?
AbstractIncreasing amount of evidence suggests that post-translational modifications (PTMs) on histones are involved in regulating DNA-associated processes such as gene expression and DNA-damage repair. To identify and characterize proteins that recognize histone PTMs, tools relying on synthetic peptides have been constructed and widely used in recent years. In this review, we first summarize the development and applications of these tools, which includes peptide-based pull-down assay and peptide-array-based high-throughput screening. The limitation of peptide-based approaches is then discussed, followed by a brief description on recent development of nucleosome-based tools.
Persistent Identifierhttp://hdl.handle.net/10722/269417
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 1.662
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLIN, J-
dc.contributor.authorLi, XD-
dc.date.accessioned2019-04-24T08:07:17Z-
dc.date.available2019-04-24T08:07:17Z-
dc.date.issued2018-
dc.identifier.citationChinese Chemical Letters, 2018, v. 29, p. 1051-1057-
dc.identifier.issn1001-8417-
dc.identifier.urihttp://hdl.handle.net/10722/269417-
dc.description.abstractIncreasing amount of evidence suggests that post-translational modifications (PTMs) on histones are involved in regulating DNA-associated processes such as gene expression and DNA-damage repair. To identify and characterize proteins that recognize histone PTMs, tools relying on synthetic peptides have been constructed and widely used in recent years. In this review, we first summarize the development and applications of these tools, which includes peptide-based pull-down assay and peptide-array-based high-throughput screening. The limitation of peptide-based approaches is then discussed, followed by a brief description on recent development of nucleosome-based tools.-
dc.languageeng-
dc.publisherElsevier Ltd for Chinese Chemical Society. The Journal's web site is located at http://www.chinchemlett.com.cn-
dc.relation.ispartofChinese Chemical Letters-
dc.subjectCrosslinkers-
dc.subjectHistone PTMs-
dc.subjectPeptide libraries-
dc.subjectPeptide microarrays-
dc.subjectPeptide pull-down-
dc.titlePeptide-based Approaches To Identify And Characterize Proteins That Recognize Histone Post-translational Modifications-
dc.typeArticle-
dc.identifier.emailLi, XD: xiangli@hku.hk-
dc.identifier.authorityLi, XD=rp01562-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cclet.2018.05.017-
dc.identifier.scopuseid_2-s2.0-85046859714-
dc.identifier.hkuros297531-
dc.identifier.volume29-
dc.identifier.spage1051-
dc.identifier.epage1057-
dc.identifier.isiWOS:000438004700009-
dc.publisher.placeChina-
dc.identifier.issnl1001-8417-

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