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- Publisher Website: 10.1101/sqb.2015.80.027649
- Scopus: eid_2-s2.0-84978764341
- PMID: 26370409
- WOS: WOS:000482630400012
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Conference Paper: Resolution of recombination intermediates: Mechanisms and regulation
Title | Resolution of recombination intermediates: Mechanisms and regulation |
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Authors | |
Issue Date | 2016 |
Citation | 21st Century Genetics Genes at Work, Huntington, WV, 26-31 May 2015. In Cold Spring Harbor Symposia on Quantitative Biology, 2016, v. 80, p. 103-109 How to Cite? |
Abstract | DNA strand break repair by homologous recombination leads to the formation of intermediates in which sister chromatids are covalently linked. The efficient processing of these joint molecules, which often contain four-way structures known as Holliday junctions, is necessary for efficient chromosome segregation during mitotic division. Because persistent chromosome bridges pose a threat to genome stability, cells ensure the complete elimination of joint molecules through three independent pathways. These involve (1) BLM-Topoisomerase IIIa-RMI1-RMI2 (BTR complex), (2) SLX1-SLX4-MUS81- EME1 (SLX-MUS complex), and (3) GEN1. The BTR pathway promotes the dissolution of double Holliday junctions, which avoids the formation of crossover products, prevents sister chromatid exchanges, and limits the potential for loss of heterozygosity. In contrast to BTR, the other two pathways resolve Holliday junctions by nucleolytic cleavage to yield crossover and non-crossover products. To avoid competition with BTR, the resolution pathways are restrained until the late stages of the cell cycle. The temporal regulation of the dissolution/resolution pathways is therefore critical for crossover avoidance while also ensuring that all covalent links between chromosomes are resolved before chromosome segregation. © 2015 Cold Spring Harbor Laboratory Press. |
Persistent Identifier | http://hdl.handle.net/10722/268582 |
ISSN | 2023 SCImago Journal Rankings: 0.872 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | West, Stephen C. | - |
dc.contributor.author | Blanco, Miguel G. | - |
dc.contributor.author | Chan, Ying Wai | - |
dc.contributor.author | Matos, Joao | - |
dc.contributor.author | Sarbajna, Shriparna | - |
dc.contributor.author | Wyatt, Haley D.M. | - |
dc.date.accessioned | 2019-03-25T08:00:07Z | - |
dc.date.available | 2019-03-25T08:00:07Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | 21st Century Genetics Genes at Work, Huntington, WV, 26-31 May 2015. In Cold Spring Harbor Symposia on Quantitative Biology, 2016, v. 80, p. 103-109 | - |
dc.identifier.issn | 0091-7451 | - |
dc.identifier.uri | http://hdl.handle.net/10722/268582 | - |
dc.description.abstract | DNA strand break repair by homologous recombination leads to the formation of intermediates in which sister chromatids are covalently linked. The efficient processing of these joint molecules, which often contain four-way structures known as Holliday junctions, is necessary for efficient chromosome segregation during mitotic division. Because persistent chromosome bridges pose a threat to genome stability, cells ensure the complete elimination of joint molecules through three independent pathways. These involve (1) BLM-Topoisomerase IIIa-RMI1-RMI2 (BTR complex), (2) SLX1-SLX4-MUS81- EME1 (SLX-MUS complex), and (3) GEN1. The BTR pathway promotes the dissolution of double Holliday junctions, which avoids the formation of crossover products, prevents sister chromatid exchanges, and limits the potential for loss of heterozygosity. In contrast to BTR, the other two pathways resolve Holliday junctions by nucleolytic cleavage to yield crossover and non-crossover products. To avoid competition with BTR, the resolution pathways are restrained until the late stages of the cell cycle. The temporal regulation of the dissolution/resolution pathways is therefore critical for crossover avoidance while also ensuring that all covalent links between chromosomes are resolved before chromosome segregation. © 2015 Cold Spring Harbor Laboratory Press. | - |
dc.language | eng | - |
dc.relation.ispartof | Cold Spring Harbor Symposia on Quantitative Biology | - |
dc.title | Resolution of recombination intermediates: Mechanisms and regulation | - |
dc.type | Conference_Paper | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1101/sqb.2015.80.027649 | - |
dc.identifier.pmid | 26370409 | - |
dc.identifier.scopus | eid_2-s2.0-84978764341 | - |
dc.identifier.volume | 80 | - |
dc.identifier.spage | 103 | - |
dc.identifier.epage | 109 | - |
dc.identifier.eissn | 1943-4456 | - |
dc.identifier.isi | WOS:000482630400012 | - |
dc.identifier.issnl | 0091-7451 | - |