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Article: Factors associated with cysticidal treatment response in extraparenchymal neurocysticercosis

TitleFactors associated with cysticidal treatment response in extraparenchymal neurocysticercosis
Authors
Issue Date2019
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-4604
Citation
Journal of Clinical Pharmacology, 2019, v. 59 n. 4, p. 548-556 How to Cite?
AbstractExtraparenchymal neurocysticercosis is the most severe form of cysticercosis, and response to treatment is suboptimal. We sought to determine how demographic and clinical characteristics and albendazole sulfoxide concentrations were related to cysticidal treatment response. We conducted a longitudinal study of 31 participants with extraparenchymal vesicular parasites who received the same treatment, albendazole 30 mg/kg/day for 10 days with dexamethasone 0.4 mg/kg/day for 13 days, followed by a prednisone taper. Response to treatment was determined by parasite volumes before and 6 months after treatment. Eight participants (25.8%) had a complete treatment response, 16 (51.6%) had a treatment response > 50% but < 100%, and 7 (22.6%) had a treatment response < 50%. Complete treatment response was significantly associated with higher concentrations of albendazole sulfoxide (P = .032), younger age (P = .032), fewer cysts (P = .049) and lower pretreatment parasite volume (P = .037). Higher number of previous cysticidal treatment courses was associated with a noncomplete treatment response (P = .023). Although the large proportion of participants with less than a complete response emphasizes the need to develop more efficacious pharmacologic regimens, the association of albendazole sulfoxide concentrations with treatment response highlights the importance of optimizing existing therapeutic regimens. In addition, the association of treatment response with parasite volume emphasizes the importance of early diagnosis.
Persistent Identifierhttp://hdl.handle.net/10722/268263
ISSN
2017 Impact Factor: 2.881
2015 SCImago Journal Rankings: 0.972

 

DC FieldValueLanguage
dc.contributor.authorOsorio, R-
dc.contributor.authorCarrillo-Mezo, R-
dc.contributor.authorRomo, ML-
dc.contributor.authorToledo, A-
dc.contributor.authorMatus, C-
dc.contributor.authorGonzales-Hernandez, L-
dc.contributor.authorJung, HJ-
dc.contributor.authorFleury, A-
dc.date.accessioned2019-03-18T04:21:59Z-
dc.date.available2019-03-18T04:21:59Z-
dc.date.issued2019-
dc.identifier.citationJournal of Clinical Pharmacology, 2019, v. 59 n. 4, p. 548-556-
dc.identifier.issn0091-2700-
dc.identifier.urihttp://hdl.handle.net/10722/268263-
dc.description.abstractExtraparenchymal neurocysticercosis is the most severe form of cysticercosis, and response to treatment is suboptimal. We sought to determine how demographic and clinical characteristics and albendazole sulfoxide concentrations were related to cysticidal treatment response. We conducted a longitudinal study of 31 participants with extraparenchymal vesicular parasites who received the same treatment, albendazole 30 mg/kg/day for 10 days with dexamethasone 0.4 mg/kg/day for 13 days, followed by a prednisone taper. Response to treatment was determined by parasite volumes before and 6 months after treatment. Eight participants (25.8%) had a complete treatment response, 16 (51.6%) had a treatment response > 50% but < 100%, and 7 (22.6%) had a treatment response < 50%. Complete treatment response was significantly associated with higher concentrations of albendazole sulfoxide (P = .032), younger age (P = .032), fewer cysts (P = .049) and lower pretreatment parasite volume (P = .037). Higher number of previous cysticidal treatment courses was associated with a noncomplete treatment response (P = .023). Although the large proportion of participants with less than a complete response emphasizes the need to develop more efficacious pharmacologic regimens, the association of albendazole sulfoxide concentrations with treatment response highlights the importance of optimizing existing therapeutic regimens. In addition, the association of treatment response with parasite volume emphasizes the importance of early diagnosis.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-4604-
dc.relation.ispartofJournal of Clinical Pharmacology-
dc.rightsThis is the peer reviewed version of the following article: Journal of Clinical Pharmacology, 2019, v. 59 n. 4, p. 548-556, which has been published in final form at https://doi.org/10.1002/jcph.1346. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.titleFactors associated with cysticidal treatment response in extraparenchymal neurocysticercosis-
dc.typeArticle-
dc.identifier.emailRomo, ML: mromo@hku.hk-
dc.description.naturepostprint-
dc.identifier.doi10.1002/jcph.1346-
dc.identifier.hkuros297185-
dc.identifier.volume59-
dc.identifier.issue4-
dc.identifier.spage548-
dc.identifier.epage556-
dc.publisher.placeUnited States-

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