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Article: Is bridge to surgery stenting a safe alternative to emergency surgery in malignant colonic obstruction: a meta-analysis of randomized control trials

TitleIs bridge to surgery stenting a safe alternative to emergency surgery in malignant colonic obstruction: a meta-analysis of randomized control trials
Authors
KeywordsColon obstruction
Bridge to surgery
Stent
Colorectal cancer
SEMS
Issue Date2019
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00464/
Citation
Surgical Endoscopy, 2019, v. 33 n. 1, p. 293-302 How to Cite?
AbstractBackground: Despite studies showing superior results in terms of reduced stoma rate and higher primary anastomosis rate, the safety of bridge to surgery stenting (BTS stent) for left-sided malignant colonic obstruction, especially in oncological terms, remains a concern. Aim: The aim of this meta-analysis was to evaluate whether BTS stent is a safe alternative to emergency surgery (EmS). Methods: Randomized control trials (RCTs) comparing BTS stent and EmS for left-sided colonic obstruction caused by primary cancer of the colon, up to Sep 2018, were retrieved from the Pubmed, Embase database, clinical trials registry of U. S. National Library of Medicine and BMJ and Google Search. Results: There were seven eligible RCTs, involving a total of 448 patients. Compared to EmS, BTS stent had a significantly lower risk of overall complications (RR = 0.605; 95% CI 0.382–0.958; p = 0.032). However, the overall recurrence rate was higher in the BTS stent group (37.0% vs. 25.9%; RR = 1.425; 95% CI 1.002–2.028; p = 0.049). BTS stent significantly increased the risk of systemic recurrence (RR = 1.627; 95% CI 1.009–2.621; p = 0.046). This did not translate into a significant difference in terms of 3-year disease-free survival or 3-year overall survival. Conclusion: BTS stent is associated with a lower rate of overall morbidities than EmS. However, BTS stent was associated with a greater chance of recurrence, especially systemic recurrence. Clinicians ought to be aware of the pros and cons of different interventions and tailor treatments for patients suffering from left-sided obstructing cancer of the colon.
Persistent Identifierhttp://hdl.handle.net/10722/268223
ISSN
2017 Impact Factor: 3.117
2015 SCImago Journal Rankings: 1.695
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFoo, CC-
dc.contributor.authorPoon, SHT-
dc.contributor.authorChiu, RHY-
dc.contributor.authorLam, WY-
dc.contributor.authorCheung, LC-
dc.contributor.authorLaw, WL-
dc.date.accessioned2019-03-18T04:21:11Z-
dc.date.available2019-03-18T04:21:11Z-
dc.date.issued2019-
dc.identifier.citationSurgical Endoscopy, 2019, v. 33 n. 1, p. 293-302-
dc.identifier.issn0930-2794-
dc.identifier.urihttp://hdl.handle.net/10722/268223-
dc.description.abstractBackground: Despite studies showing superior results in terms of reduced stoma rate and higher primary anastomosis rate, the safety of bridge to surgery stenting (BTS stent) for left-sided malignant colonic obstruction, especially in oncological terms, remains a concern. Aim: The aim of this meta-analysis was to evaluate whether BTS stent is a safe alternative to emergency surgery (EmS). Methods: Randomized control trials (RCTs) comparing BTS stent and EmS for left-sided colonic obstruction caused by primary cancer of the colon, up to Sep 2018, were retrieved from the Pubmed, Embase database, clinical trials registry of U. S. National Library of Medicine and BMJ and Google Search. Results: There were seven eligible RCTs, involving a total of 448 patients. Compared to EmS, BTS stent had a significantly lower risk of overall complications (RR = 0.605; 95% CI 0.382–0.958; p = 0.032). However, the overall recurrence rate was higher in the BTS stent group (37.0% vs. 25.9%; RR = 1.425; 95% CI 1.002–2.028; p = 0.049). BTS stent significantly increased the risk of systemic recurrence (RR = 1.627; 95% CI 1.009–2.621; p = 0.046). This did not translate into a significant difference in terms of 3-year disease-free survival or 3-year overall survival. Conclusion: BTS stent is associated with a lower rate of overall morbidities than EmS. However, BTS stent was associated with a greater chance of recurrence, especially systemic recurrence. Clinicians ought to be aware of the pros and cons of different interventions and tailor treatments for patients suffering from left-sided obstructing cancer of the colon.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer-ny.com/link/service/journals/00464/-
dc.relation.ispartofSurgical Endoscopy-
dc.subjectColon obstruction-
dc.subjectBridge to surgery-
dc.subjectStent-
dc.subjectColorectal cancer-
dc.subjectSEMS-
dc.titleIs bridge to surgery stenting a safe alternative to emergency surgery in malignant colonic obstruction: a meta-analysis of randomized control trials-
dc.typeArticle-
dc.identifier.emailFoo, CC: ccfoo@hku.hk-
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hk-
dc.identifier.authorityFoo, CC=rp01899-
dc.identifier.authorityLaw, WL=rp00436-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00464-018-6487-3-
dc.identifier.pmid30341649-
dc.identifier.scopuseid_2-s2.0-85055587007-
dc.identifier.hkuros297064-
dc.identifier.volume33-
dc.identifier.issue1-
dc.identifier.spage293-
dc.identifier.epage302-
dc.identifier.isiWOS:000456089200035-
dc.publisher.placeUnited States-

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