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Article: Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy

TitleMicroneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy
Authors
KeywordsCancer therapy
Cisplatin
Drug delivery
Microneedle
Nanoparticle
Issue Date2018
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick
Citation
ACS Applied Materials & Interfaces, 2018, v. 10 n. 39, p. 33060-33069 How to Cite?
AbstractCisplatin is the first-line chemotherapeutic agent, but its systemic toxicity and side effects severely limit its clinical use. We report a microneedle technique to mediate the transdermal delivery of lipid-coated cisplatin nanoparticles (LCC-NPs) for efficient and safe cancer therapy. Cisplatin was encapsulated by tumor-targeting pH-responsive lipid nanoparticles with a high loading rate of 80%, and the encapsulation substantially increased the solubility of cisplatin and enhanced its antitumor efficiency in vitro. The LCC-NPs were embedded in dissolvable microneedles, and released from the microneedles after inserting into the skin. This enabled the nanoparticles to pass the stratum corneum for safe local delivery. An in vivo study with a xenograft tumor animal model demonstrated that microneedle arrays loaded with cisplatin nanoparticles significantly increased cytotoxicity and apoptosis in cancer cells with an apoptotic index of 58.6%, resulting in significantly reduced tumor volume and weight. Moreover, serum platinum, pulmonary toxicity, hepatotoxicity, and nephrotoxicity were not detected in vivo, indicating that this technique is biosafe. The cisplatin-nanoparticle microneedle system developed in this study may offer promising opportunities in cancer therapy for enhancing antitumor effects and reducing systemic toxicity and side effects.
Persistent Identifierhttp://hdl.handle.net/10722/266434
ISSN
2017 Impact Factor: 8.097
2015 SCImago Journal Rankings: 2.381
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLan, X-
dc.contributor.authorShe, J-
dc.contributor.authorLin, D-
dc.contributor.authorXu, Y-
dc.contributor.authorLi, X-
dc.contributor.authorYang, W-
dc.contributor.authorLui, VWY-
dc.contributor.authorJin, L-
dc.contributor.authorXie, X-
dc.contributor.authorSu, Y-
dc.date.accessioned2019-01-18T08:19:34Z-
dc.date.available2019-01-18T08:19:34Z-
dc.date.issued2018-
dc.identifier.citationACS Applied Materials & Interfaces, 2018, v. 10 n. 39, p. 33060-33069-
dc.identifier.issn1944-8244-
dc.identifier.urihttp://hdl.handle.net/10722/266434-
dc.description.abstractCisplatin is the first-line chemotherapeutic agent, but its systemic toxicity and side effects severely limit its clinical use. We report a microneedle technique to mediate the transdermal delivery of lipid-coated cisplatin nanoparticles (LCC-NPs) for efficient and safe cancer therapy. Cisplatin was encapsulated by tumor-targeting pH-responsive lipid nanoparticles with a high loading rate of 80%, and the encapsulation substantially increased the solubility of cisplatin and enhanced its antitumor efficiency in vitro. The LCC-NPs were embedded in dissolvable microneedles, and released from the microneedles after inserting into the skin. This enabled the nanoparticles to pass the stratum corneum for safe local delivery. An in vivo study with a xenograft tumor animal model demonstrated that microneedle arrays loaded with cisplatin nanoparticles significantly increased cytotoxicity and apoptosis in cancer cells with an apoptotic index of 58.6%, resulting in significantly reduced tumor volume and weight. Moreover, serum platinum, pulmonary toxicity, hepatotoxicity, and nephrotoxicity were not detected in vivo, indicating that this technique is biosafe. The cisplatin-nanoparticle microneedle system developed in this study may offer promising opportunities in cancer therapy for enhancing antitumor effects and reducing systemic toxicity and side effects.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick-
dc.relation.ispartofACS Applied Materials & Interfaces-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.8b12926.-
dc.subjectCancer therapy-
dc.subjectCisplatin-
dc.subjectDrug delivery-
dc.subjectMicroneedle-
dc.subjectNanoparticle-
dc.titleMicroneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy-
dc.typeArticle-
dc.identifier.emailLi, X: llx815@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.emailSu, Y: richsu@hku.hk-
dc.identifier.authorityLi, X=rp02494-
dc.identifier.authorityJin, L=rp00028-
dc.identifier.authoritySu, Y=rp01916-
dc.description.naturepostprint-
dc.identifier.doi10.1021/acsami.8b12926-
dc.identifier.scopuseid_2-s2.0-85054135674-
dc.identifier.hkuros296657-
dc.identifier.volume10-
dc.identifier.issue39-
dc.identifier.spage33060-
dc.identifier.epage33069-
dc.identifier.isiWOS:000446919800014-
dc.publisher.placeUnited States-

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