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Book Chapter: Animal Models of Diabetic Retinopathy (Part 2)
Title | Animal Models of Diabetic Retinopathy (Part 2) |
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Authors | |
Keywords | Animals Blood glucose Blindness Diabetic complications Diabetes mellitus/pathology/physiopathology |
Issue Date | 2018 |
Publisher | IntechOpen. |
Citation | Animal Models of Diabetic Retinopathy (Part 2). In Bartholomew, I (Eds.), Experimetnal Animal Models of Human Diseases – An Effective Therapeutic Strategy, p. 41-68. London, UK: IntechOpen, 2018 How to Cite? |
Abstract | Diabetic retinopathy (DR) is one of the leading causes of preventable vision impairment and blindness in the working-age population worldwide. Numerous animal models have been developed for therapeutic drug screening and to further increase our understanding of the molecular and cellular pathological processes involved in DR. Following our discussion of mouse models in “Animal Models of Diabetic Retinopathy Part 1,” we describe the cellular, molecular, and morphological features of both rodent and nonrodent models of DR and their respective advantages and limitations in this chapter. To date, no animal model can holistically reproduce the pathological progression of human DR; most only display early or advanced lesions of DR. However, a thorough understanding of genotypic and phenotypic expressions of existing models will facilitate researchers’ selection of the appropriate model to simulate their desired clinical scenarios. |
Persistent Identifier | http://hdl.handle.net/10722/265944 |
ISBN |
DC Field | Value | Language |
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dc.contributor.author | Tang, LHC | - |
dc.contributor.author | Wong, YHI | - |
dc.contributor.author | Lo, ACY | - |
dc.date.accessioned | 2018-12-17T02:14:09Z | - |
dc.date.available | 2018-12-17T02:14:09Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Animal Models of Diabetic Retinopathy (Part 2). In Bartholomew, I (Eds.), Experimetnal Animal Models of Human Diseases – An Effective Therapeutic Strategy, p. 41-68. London, UK: IntechOpen, 2018 | - |
dc.identifier.isbn | 9781789231656 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265944 | - |
dc.description.abstract | Diabetic retinopathy (DR) is one of the leading causes of preventable vision impairment and blindness in the working-age population worldwide. Numerous animal models have been developed for therapeutic drug screening and to further increase our understanding of the molecular and cellular pathological processes involved in DR. Following our discussion of mouse models in “Animal Models of Diabetic Retinopathy Part 1,” we describe the cellular, molecular, and morphological features of both rodent and nonrodent models of DR and their respective advantages and limitations in this chapter. To date, no animal model can holistically reproduce the pathological progression of human DR; most only display early or advanced lesions of DR. However, a thorough understanding of genotypic and phenotypic expressions of existing models will facilitate researchers’ selection of the appropriate model to simulate their desired clinical scenarios. | - |
dc.language | eng | - |
dc.publisher | IntechOpen. | - |
dc.relation.ispartof | Experimetnal Animal Models of Human Diseases – An Effective Therapeutic Strategy | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Animals | - |
dc.subject | Blood glucose | - |
dc.subject | Blindness | - |
dc.subject | Diabetic complications | - |
dc.subject | Diabetes mellitus/pathology/physiopathology | - |
dc.title | Animal Models of Diabetic Retinopathy (Part 2) | - |
dc.type | Book_Chapter | - |
dc.identifier.email | Wong, YHI: wongyhi@hku.hk | - |
dc.identifier.email | Lo, ACY: amylo@hku.hk | - |
dc.identifier.authority | Wong, YHI=rp01467 | - |
dc.identifier.authority | Lo, ACY=rp00425 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.5772/intechopen.70589 | - |
dc.identifier.spage | 41 | - |
dc.identifier.epage | 68 | - |
dc.publisher.place | London, UK | - |