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- Publisher Website: 10.1002/nbm.3745
- Scopus: eid_2-s2.0-85020072967
- PMID: 28574615
- WOS: WOS:000407653900011
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Article: Simultaneous spin-echo and gradient-echo BOLD measurements by dynamic MRS
Title | Simultaneous spin-echo and gradient-echo BOLD measurements by dynamic MRS |
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Authors | |
Keywords | BOLD inferior colliculus spin echo gradient echo functional MRS |
Issue Date | 2017 |
Citation | NMR in Biomedicine, 2017, v. 30, n. 9, article no. e3745 How to Cite? |
Abstract | Copyright © 2017 John Wiley & Sons, Ltd. This study aimed to dissociate the intravascular and extravascular contributions to spin-echo (SE) and gradient-echo (GE) blood oxygenation level-dependent (BOLD) signals at 7 T, using dynamic diffusion-weighted MRS. We simultaneously acquired SE and GE data using a point-resolved spectroscopy sequence with diffusion weightings of 0, 600, and 1200 s/mm2. The BOLD signals were quantified by fitting the free induction decays starting from the SE center to a mono-exponential decay function. Without diffusion weighting, BOLD signals measured with SE and GE increased by 1.6 ± 0.5% (TESE = 40 ms) and 5.2 ± 1.4% (nominal TEGE = 40 ms) during stimulation, respectively. With diffusion weighting, the BOLD increase during stimulation measured with SE decreased from 1.6 ± 0.5% to 1.3 ± 0.4% (P < 0.001), whereas that measured by GE was unaffected (P > 0.05); the post-stimulation undershoots in the BOLD signal time courses were largely preserved in both SE and GE measurements. These results demonstrated the feasiblity of simultaneous SE and GE measurements of BOLD signals with and without interleaved diffusion weighting. The results also indicated a predominant extravascular contribution to the BOLD signal time courses, including post-stimulation undershoots in both SE and GE measurements at 7 T. |
Persistent Identifier | http://hdl.handle.net/10722/265705 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.949 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cao, Peng | - |
dc.contributor.author | Hyder, Fahmeed | - |
dc.contributor.author | Zhou, Iris Y. | - |
dc.contributor.author | Zhang, Jevin W. | - |
dc.contributor.author | Xie, Victor B. | - |
dc.contributor.author | Tsang, Adrian | - |
dc.contributor.author | Wu, Ed X. | - |
dc.date.accessioned | 2018-12-03T01:21:27Z | - |
dc.date.available | 2018-12-03T01:21:27Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | NMR in Biomedicine, 2017, v. 30, n. 9, article no. e3745 | - |
dc.identifier.issn | 0952-3480 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265705 | - |
dc.description.abstract | Copyright © 2017 John Wiley & Sons, Ltd. This study aimed to dissociate the intravascular and extravascular contributions to spin-echo (SE) and gradient-echo (GE) blood oxygenation level-dependent (BOLD) signals at 7 T, using dynamic diffusion-weighted MRS. We simultaneously acquired SE and GE data using a point-resolved spectroscopy sequence with diffusion weightings of 0, 600, and 1200 s/mm2. The BOLD signals were quantified by fitting the free induction decays starting from the SE center to a mono-exponential decay function. Without diffusion weighting, BOLD signals measured with SE and GE increased by 1.6 ± 0.5% (TESE = 40 ms) and 5.2 ± 1.4% (nominal TEGE = 40 ms) during stimulation, respectively. With diffusion weighting, the BOLD increase during stimulation measured with SE decreased from 1.6 ± 0.5% to 1.3 ± 0.4% (P < 0.001), whereas that measured by GE was unaffected (P > 0.05); the post-stimulation undershoots in the BOLD signal time courses were largely preserved in both SE and GE measurements. These results demonstrated the feasiblity of simultaneous SE and GE measurements of BOLD signals with and without interleaved diffusion weighting. The results also indicated a predominant extravascular contribution to the BOLD signal time courses, including post-stimulation undershoots in both SE and GE measurements at 7 T. | - |
dc.language | eng | - |
dc.relation.ispartof | NMR in Biomedicine | - |
dc.subject | BOLD | - |
dc.subject | inferior colliculus | - |
dc.subject | spin echo | - |
dc.subject | gradient echo | - |
dc.subject | functional MRS | - |
dc.title | Simultaneous spin-echo and gradient-echo BOLD measurements by dynamic MRS | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/nbm.3745 | - |
dc.identifier.pmid | 28574615 | - |
dc.identifier.scopus | eid_2-s2.0-85020072967 | - |
dc.identifier.hkuros | 280297 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | article no. e3745 | - |
dc.identifier.epage | article no. e3745 | - |
dc.identifier.eissn | 1099-1492 | - |
dc.identifier.isi | WOS:000407653900011 | - |
dc.identifier.issnl | 0952-3480 | - |