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- Publisher Website: 10.1016/j.celrep.2015.10.044
- Scopus: eid_2-s2.0-84946151315
- PMID: 26547238
- WOS: WOS:000364990700008
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Article: Hox Proteins Act as Transcriptional Guarantors to Ensure Terminal Differentiation
Title | Hox Proteins Act as Transcriptional Guarantors to Ensure Terminal Differentiation |
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Authors | |
Issue Date | 2015 |
Citation | Cell Reports, 2015, v. 13, n. 7, p. 1343-1352 How to Cite? |
Abstract | © 2015 The Authors. Cell differentiation usually occurs with high fidelity, but the expression of many transcription factors is variable. Using the touch receptor neurons (TRNs) in C. elegans, we found that the Hox proteins CEH-13/lab and EGL-5/Abd-B overcome this variability by facilitating the activation of the common TRN fate determinant mec-3 in the anterior and posterior TRNs, respectively. CEH-13 and EGL-5 increase the probability of mec-3 transcriptional activation by the POU-homeodomain transcription factor UNC-86 using the same Hox/Pbx binding site. Mutation of ceh-13 and egl-5 resulted in an incomplete (~40%) loss of the TRN fate in respective TRNs, which correlates with quantitative mRNA measurements showing two distinct modes (all or none) of mec-3 transcription. Therefore, Hox proteins act as transcriptional "guarantors" in order to ensure reliable and robust gene expression during terminal neuronal differentiation. Guarantors do not activate gene expression by themselves but promote full activation of target genes regulated by other transcription factors. |
Persistent Identifier | http://hdl.handle.net/10722/265678 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 4.279 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zheng, Chaogu | - |
dc.contributor.author | Jin, Felix Qiaochu | - |
dc.contributor.author | Chalfie, Martin | - |
dc.date.accessioned | 2018-12-03T01:21:21Z | - |
dc.date.available | 2018-12-03T01:21:21Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Cell Reports, 2015, v. 13, n. 7, p. 1343-1352 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265678 | - |
dc.description.abstract | © 2015 The Authors. Cell differentiation usually occurs with high fidelity, but the expression of many transcription factors is variable. Using the touch receptor neurons (TRNs) in C. elegans, we found that the Hox proteins CEH-13/lab and EGL-5/Abd-B overcome this variability by facilitating the activation of the common TRN fate determinant mec-3 in the anterior and posterior TRNs, respectively. CEH-13 and EGL-5 increase the probability of mec-3 transcriptional activation by the POU-homeodomain transcription factor UNC-86 using the same Hox/Pbx binding site. Mutation of ceh-13 and egl-5 resulted in an incomplete (~40%) loss of the TRN fate in respective TRNs, which correlates with quantitative mRNA measurements showing two distinct modes (all or none) of mec-3 transcription. Therefore, Hox proteins act as transcriptional "guarantors" in order to ensure reliable and robust gene expression during terminal neuronal differentiation. Guarantors do not activate gene expression by themselves but promote full activation of target genes regulated by other transcription factors. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Hox Proteins Act as Transcriptional Guarantors to Ensure Terminal Differentiation | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.celrep.2015.10.044 | - |
dc.identifier.pmid | 26547238 | - |
dc.identifier.scopus | eid_2-s2.0-84946151315 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1343 | - |
dc.identifier.epage | 1352 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.isi | WOS:000364990700008 | - |
dc.identifier.f1000 | 725921482 | - |
dc.identifier.issnl | 2211-1247 | - |